492-27-3
492-27-3
Chemical Structure
Kynurenic acid
Synonym(s): Quinurenic acid; Fibrostop 2
- CAS No.: 492-27-3
- Formula:C10H7NO3
- Molecular Weight:189.17
IUPAC Name: 4-hydroxyquinoline-2-carboxylic acid
InChIKey: HCZHHEIFKROPDY-UHFFFAOYSA-N
SMILES: O=C(C1=NC2=CC=CC=C2C(O)=C1)O
Biological Activity: Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
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Kynurenic acid | 99.93% | Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8. | ||||||||||||||||||||
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Kynurenic acid (Standard) | 98.87% | Kynurenic acid (Standard) is the analytical standard of Kynurenic acid. This product is intended for research and analytical applications. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8. | ||||||||||||||||||||
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Kynurenic acid-d5 | 99.85% | Kynurenic acid-d5 is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8. | ||||||||||||||||||||
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7-Chlorokynurenic acid (Standard) | ≥98% | 7-Chlorokynurenic acid (Standard) is the analytical standard of 7-Chlorokynurenic acid. This product is intended for research and analytical applications. 7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery. | ||||||||||||||||||||
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Kynurenic acid sodium (Standard) | ≥98% | Kynurenic acid (sodium) (Standard) is the analytical standard of Kynurenic acid (sodium). This product is intended for research and analytical applications. Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8. | ||||||||||||||||||||
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IOX1 | 99.89% | IOX1, a chemical probe, is a potent broad‐spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC50 values of 0.6 μM, 2.3 μM, 1.8 μM, 0.1 μM and 1.4 μM, respectively. IOX1 also inhibits ALKBH5. | ||||||||||||||||||||
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4-Hydroxy-2-naphthoic acid | 99.68% | 4-Hydroxy-2-naphthoic acid is a drug intermediate for synthesis of various active compounds. | ||||||||||||||||||||
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Benzoic acid-d5 | 98.98% | Benzoic acid-d5 is a deuterium substitute for Benzoic acid. Benzoic acid is an aromatic alcohol that occurs naturally in many plants and is a common additive in food, beverages, cosmetics and other products. Benzoic acid can act as a preservative by inhibiting bacteria and fungi. | ||||||||||||||||||||
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6-Hydroxykynurenic acid | 99.60% | 6-Hydroxykynurenic acid (6-HKA) is a derivative of kynurenic acid (KYNA) and can be isolated from Ginkgo leaves. 6-Hydroxykynurenic acid is a low-affinity NMDAR antagonist (IC50: 59 μM). | ||||||||||||||||||||
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Quinoline-2-carboxylic acid (Standard) | 99.96% | Quinoline-2-carboxylic acid exhibits antidiabetic activity. Quinoline-2-carboxylic acid can be used as drug intermediate for synthesis of various active compounds. | ||||||||||||||||||||
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Quinoline-2-carboxylic acid-d6 | Quinoline-2-carboxylic acid-d6 is the deuterium labeled Quinoline-2-carboxylic acid (HY-W002011). Quinoline-2-carboxylic acid exhibits antidiabetic activity. Quinoline-2-carboxylic acid can be used as drug intermediate for synthesis of various active compounds. | |||||||||||||||||||||
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2-Quinoxalinecarboxylic acid | 99.20% | 2-Quinoxalinecarboxylic acid is an antibacterial agent targeting Mycobacterium tuberculosis (MIC: >128 µg/mL). 2-Quinoxalinecarboxylic acid is promising for research of tuberculosis. | ||||||||||||||||||||
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2-Quinoxalinecarboxylic acid-d4 | 98.40% | 2-Quinoxalinecarboxylic acid-d4 is the deuterium labeled 2-Quinoxalinecarboxylic acid. | ||||||||||||||||||||
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Xanthurenic acid (Standard) | 99.44% | Xanthurenic acid (Standard) is the analytical standard of Xanthurenic acid. This product is intended for research and analytical applications. Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus. | ||||||||||||||||||||
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Xanthurenic acid-d4 | 99.03% | Xanthurenic acid-d4 is the deuterium labeled Xanthurenic acid. Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus. | ||||||||||||||||||||
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1,4-Dihydroxy-2-naphthoic acid | 99.62% | 1,4-Dihydroxy-2-naphthoic acid is an aryl hydrocarbon receptor (AhR) agonist. 1,4-Dihydroxy-2-naphthoic acid is also a bacterially derived metabolite and has anti-inflammatory activity. | ||||||||||||||||||||
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3-Methyl-2-quinoxalinecarboxylic acid-d4 | 99.95% | 3-Methyl-2-quinoxalinecarboxylic acid-d4 is the deuterium labeled 3-Methyl-2-quinoxalinecarboxylic acid. 3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle. | ||||||||||||||||||||
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2-Carboxyphenol-d4 | 99.83% | 2-Carboxyphenol-d4 is the deuterium labeled 2-Carboxyphenol. 2-Carboxyphenol is a plant hormone and mediates host responses against microbial pathogens. | ||||||||||||||||||||
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BAY32-5915 | 99.18% | BAY32-5915 is a potent IKKα inhibitor with an IC50 value of 60 nM. BAY32-5915 has not affect Doxorubicin (HY-15142A)-induced NF-κB activation. | ||||||||||||||||||||
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Picolinic acid-d4 | 99.99% | Ppicolinic-3,4,5,6-d4 acid is the deuterium labeled Ppicolinic acid. | ||||||||||||||||||||
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1-Naphthoic acid-d7 | 1-Naphthoic acid-d7 (Naphthalene-1-carboxylic acid-d7) is the deuterium labeled 1-Naphthoic acid (HY-Y0236). Naphthalene-1-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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3-Hydroxyquinoline-d6 | 3-Hydroxyquinoline-d6 (Quinolin-3-ol-d6) is the deuterium labeled 3-Hydroxyquinoline (HY-W008203). | |||||||||||||||||||||
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4-Hydroxybenzoic acid-d4 | 99.97% | 4-Hydroxybenzoic acid-d4 is the deuterium labeled 4-Hydroxybenzoic acid. 4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL. | ||||||||||||||||||||
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