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Pathways Recommended: Cell Cycle/DNA Damage
Results for "

DNA Glycosylase

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

6

Recombinant Proteins

4

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-147313
    TH10785
    2 Publications Verification

    		 DNA/RNA Synthesis Metabolic Disease Cancer
    TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions .
    TH10785
  • HY-Y0958
    Methoxyamine hydrochloride
    1 Publications Verification

    O-Methylhydroxylamine hydrochloride

    		 DNA/RNA Synthesis Apoptosis Cancer
    Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents .
    Methoxyamine hydrochloride
  • HY-139056
    SU0268
    3 Publications Verification

    		 Glycosyltransferase Infection Inflammation/Immunology Cancer
    SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection .
    SU0268
  • HY-112902
    OGG1-IN-08
    2 Publications Verification

    		 DNA Glycosylase Inflammation/Immunology
    OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1 .
    OGG1-IN-08
  • HY-126181
    5-Formylcytosine

    		Endogenous Metabolite Others
    5-Formylcytosine is a modified base, which is oxidized from 5-methylcytosine. 5-Formylcytosine is a intermediate of in the active DNA demethylation .
    5-Formylcytosine
  • HY-E70575
    Endonuclease VIII

    		DNA Glycosylase Others
    Endonuclease VIII is a DNA repair enzyme that excises oxidized pyrimidines from DNA. Endonuclease VIII is a bacterial DNA glycosylase/AP lyase that excises modified pyrimidines, including thymine glycol (Tg), uracil glycol, dihydrothymine, dihydrouracil (DHU) .
    Endonuclease VIII
  • HY-E70578
    T4 Endonuclease V

    		DNA Glycosylase Others
    T4 Endonuclease V is a dual-activity DNA glycosylase that combines the activities of DNA N-glycosylase and AP lyase. T4 Endonuclease V can repair ultraviolet (UV)-induced cyclobutane pyrimidine dimers in DNA .
    T4 Endonuclease V
  • HY-E70217
    Uracil DNA Glycosylase (UDG/UNG), heat-sensitive

    Heat-sensitive UDG

    		 DNA/RNA Synthesis Cancer
    Uracil DNA Glycosylase (UDG/UNG), heat-sensitive (Heat-sensitive UDG) can catalyze the hydrolysis of the N-glycosidic bond between the uracil base and the sugar phosphate backbone in the DNA chain containing uracil, releasing free uracil. Uracil DNA Glycosylase (UDG/UNG), heat-sensitive eliminates the carryover contamination dUTP-incorporated amplification products .
    Uracil DNA Glycosylase (UDG/UNG), heat-sensitive
  • HY-E70605
    Human alkyl adenine DNA glycosylase

    		DNA/RNA Synthesis Others
    Human alkyl adenine DNA glycosylase is a monomeric DNA glycosylase that corrects a broad range of alkylated and deaminated nucleobases to maintain genomic integrity .
    Human alkyl adenine DNA glycosylase
  • HY-179014
    OGG1 activator-1

    		DNA Glycosylase Neurological Disease Inflammation/Immunology Cancer
    OGG1 activator-1 (Compound 30) is a selective 8-oxoguanine DNA glycosylase-1 (OGG1) activator with an AC50 value of 0.58 μM. OGG1 activator-1 does not activate nor inhibit the key downstream repair enzyme APE1, and shows > 150-fold selectivity for the activation effect on OGG1. OGG1 activator-1 exhibits extremely high metabolic stability and almost no cytotoxicity. OGG1 activator-1 can be used for the study of oxidative stress-related diseases (such as neurodegenerative diseases, fibrotic diseases, cancer, inflammation, etc.) .
    OGG1 activator-1
  • HY-P2926
    Formamidopyrimidine-DNA glycosidase

    		DNA/RNA Synthesis Neurological Disease Cancer
    Formamidopyrimidine-DNA glycosylase is a selective DNA repair enzyme. Formamidopyrimidine-DNA glycosylase is promising for research of DNA damage repair and the and oxidative stress-related diseases (e.g., cancer, neurodegenerative diseases) .
    Formamidopyrimidine-DNA glycosidase
  • HY-149349
    MtUng-IN-1

    		Bacterial Infection Cancer
    MtUng-IN-1 (Compound 18a) is a Uracil DNA glycosylase of Mycobacterium (MtUng) inhibitor (IC50: 300 μM). MtUng-IN-1 can be used for research of cancers and infectious diseases .
    MtUng-IN-1
  • HY-Y0958R
    Methoxyamine hydrochloride (Standard)

    O-Methylhydroxylamine hydrochloride (Standard)

    		 Reference Standards DNA/RNA Synthesis Apoptosis Cancer
    Methoxyamine hydrochloride (Standard) is the analytical standard of Methoxyamine hydrochloride. This product is intended for research and analytical applications. Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents .
    Methoxyamine hydrochloride (Standard)
  • HY-181440
    TDG-IN-1

    		DNA Glycosylase DNA/RNA Synthesis Cancer
    TDG-IN-1 is an orally active, selective small-molecule inhibitor of thymine DNA glycosylase (TDG) with a Ka of 1.46 nM. TDG-IN-1 impairs the DNA-binding ability of TDG, induces downregulated expression of DHX9, accumulation of double-stranded RNA, and activation of the RIG-I/MDA5-MAVS pathway, while acting as a tumor suppressor, innate immune activator and immunostimulant. TDG-IN-1 inhibits the growth of p53-deficient tumor cells and xenograft tumors, and exerts a synthetic lethal effect with p53. TDG-IN-1 is applicable to the research of p53-deficient cancers .
    TDG-IN-1
  • HY-W974306
    DML3

    		DNA/RNA Synthesis Cancer
    DML3, a 5-methylcytosine DNA glycosylase, is a DNA demethylating agent. DML3 specifically recognizes and excises 5-methylcytosine (5-meC) from DNA through a base excision repair mechanism. DML3 is promising for research of plant epigenetic regulation and cancers .
    DML3

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