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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
DNA Glycosylase
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "DNA Glycosylase" in MCE Product Catalog:
5
5 Cited Publications
Target:
Research Areas:
SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection .
3
3 Cited Publications
Target:
Research Areas:
TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions .
3
3 Cited Publications
Target:
Research Areas:
OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1 .
3
3 Cited Publications
Cat. No.: HY-P70968
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: OGG1; DNA-(Apurinic Or Apyrimidinic Site) Lyase; 8-Oxoguanine DNA Glycosylase; DNA-Apurinic Or Apyrimidinic Site Lyase; OGH1; OGG1 Type 1e; MUTM; OGG1 Type 1d; N-Glycosylase/DNA Lyase; OGG1 Type 1g; HOGG1; OGG1 Type 1h; HMMH; OGG1 Type 1f; 8-Hydroxyguanin
Species:
Human
Source:
E. coli
1
1 Cited Publications
Synonyms: O-Methylhydroxylamine hydrochloride
Target:
Research Areas:
Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents .
1
1
1 Cited Publications
Cat. No.: HY-P72338
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: OGG1; DNA-(Apurinic Or Apyrimidinic Site) Lyase; 8-Oxoguanine DNA Glycosylase; DNA-Apurinic Or Apyrimidinic Site Lyase; OGH1; OGG1 Type 1e; MUTM; OGG1 Type 1d; N-Glycosylase/DNA Lyase; OGG1 Type 1g; HOGG1; OGG1 Type 1h; HMMH; OGG1 Type 1f; 8-Hydroxyguanin
Species:
Human
Source:
E. coli
Target:
Research Areas:
5-Formylcytosine is a modified base, which is oxidized from 5-methylcytosine. 5-Formylcytosine is a intermediate of in the active DNA demethylation .
Cat. No.: HY-E70575
CAS No.: 118390-70-8
Target:
Research Areas:
Endonuclease VIII is a DNA repair enzyme that excises oxidized pyrimidines from DNA. Endonuclease VIII is a bacterial DNA glycosylase/AP lyase that excises modified pyrimidines, including thymine glycol (Tg), uracil glycol, dihydrothymine, dihydrouracil (DHU) .
Cat. No.: HY-E70578
CAS No.: 52227-85-7
Target:
Research Areas:
T4 Endonuclease V is a dual-activity DNA glycosylase that combines the activities of DNA N-glycosylase and AP lyase. T4 Endonuclease V can repair ultraviolet (UV)-induced cyclobutane pyrimidine dimers in DNA .
Cat. No.: HY-E70217
CAS No.: 59088-21-0
Synonyms: Heat-sensitive UDG
Target:
Research Areas:
Uracil DNA Glycosylase (UDG/UNG), heat-sensitive (Heat-sensitive UDG) can catalyze the hydrolysis of the N-glycosidic bond between the uracil base and the sugar phosphate backbone in the DNA chain containing uracil, releasing free uracil. Uracil DNA Glycosylase (UDG/UNG), heat-sensitive eliminates the carryover contamination dUTP-incorporated amplification products .
Cat. No.: HY-E70605
Target:
Research Areas:
Human alkyl adenine DNA glycosylase is a monomeric DNA glycosylase that corrects a broad range of alkylated and deaminated nucleobases to maintain genomic integrity .
Cat. No.: HY-179014
Target:
Research Areas:
OGG1 activator-1 (Compound 30) is a selective 8-oxoguanine DNA glycosylase-1 (OGG1) activator with an AC50 value of 0.58 μM. OGG1 activator-1 does not activate nor inhibit the key downstream repair enzyme APE1, and shows > 150-fold selectivity for the activation effect on OGG1. OGG1 activator-1 exhibits extremely high metabolic stability and almost no cytotoxicity. OGG1 activator-1 can be used for the study of oxidative stress-related diseases (such as neurodegenerative diseases, fibrotic diseases, cancer, inflammation, etc.) .
Cat. No.: HY-P2926
CAS No.: 78783-53-6
Target:
Research Areas:
Formamidopyrimidine-DNA glycosylase is a selective DNA repair enzyme. Formamidopyrimidine-DNA glycosylase is promising for research of DNA damage repair and the and oxidative stress-related diseases (e.g., cancer, neurodegenerative diseases) .
Research Areas:
Methoxyamine hydrochloride (Standard) is the analytical standard of Methoxyamine hydrochloride. This product is intended for research and analytical applications. Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents .
Cat. No.: HY-P702783
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TDG; Thymine-DNA Glycosylase; Thymine DNA Glycosylase; HTDG; G/T Mismatch-Specific Thymine DNA Glycosylase; TDG Protein
Species:
Human
Source:
E. coli
Cat. No.: HY-P73562
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UNG; Uracil DNA Glycosylase; DGU; UNG1; UDG; Uracil-DNA Glycosylase; HIGM4; UNG2; Uracil-DNA Glycosylase 1,Uracil-DNA Glycosylase 2; UNG15; Uncharacterized Protein DKFZp781L1143; DKFZp781L1143; HIGM5
Species:
Human
Source:
E. coli
Cat. No.: HY-P78944
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UNG; Uracil DNA Glycosylase; DGU; UNG1; UDG; Uracil-DNA Glycosylase; HIGM4; UNG2; Uracil-DNA Glycosylase 1,Uracil-DNA Glycosylase 2; UNG15; Uncharacterized Protein DKFZp781L1143; DKFZp781L1143; HIGM5
Species:
E.coli
Source:
E. coli
Cat. No.: HY-P86963
Synonyms: 3 alkyladenine DNA Glycosylase antibody; 3-alkyladenine DNA Glycosylase antibody; 3-methyladenine DNA glycosidase antibody; 3MG_HUMAN antibody; AAG antibody; ADPG antibody; Alkyladenine DNA Glycosylase antibody; anpg antibody; APNG antibody; CRA36.1 antibody; 3 alkyladenine DNA Glycosylase antibody; 3-alkyladenine DNA Glycosylase antibody; 3-methyladenine DNA glycosidase antibody; 3MG_HUMAN antibody; AAG antibody; ADPG antibody; Alkyladenine DNA Glycosylase antibody; anpg antibody; APNG antibody; CRA36.1 antibody; DNA 3 methyladenine Glycosylase antibody; DNA-3-methyladenine Glycosylase antibody; MDG antibody; Mid1 antibody; Mpg antibody; N methylpurine DNA glycosirase antibody; N methylpurine DNA Glycosylase antibody; N-methylpurine-DNA Glycosylase antibody; PIG11 antibody; PIG16 antibody; Proliferation inducing protein 11 antibody; Proliferation inducing protein 16 antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
