Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
EphA2 receptors
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "EphA2 receptors" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P10579
CAS No.: 2225868-19-7
Target:
Research Areas:
Cat. No.: HY-P991577
Synonyms: DS-8895A
Target:
Research Areas:
Target:
Research Areas:
UniPR129 is a potent and orally active Eph/ephrin antagonist. UniPR129 can inhibit EphA2-ephrin-A1 interaction with an IC50 of 945 nM and a Ki of 370 nM. UniPR129 can inhibit angiogenesis and show antitumor and neuroprotective effect. UniPR129 can be used for the researches of cancer and neurological disease, such as colorectal cancer and optic neuropathy .
Target:
Research Areas:
EphA2 agonist 1 (Compound 7bg) is a potent EphA2 receptor agonist. EphA2 agonist 1 shows great potency and selectivity toward EphA2 overexpressed glioblastoma cells and stimulates EphA2 phosphorylation .
Cat. No.: HY-P3717
CAS No.: 3031514-44-7
Target:
Research Areas:
Synonyms: 3,4,8,9-Tetrahydroxy urolithin
Target:
Cat. No.: HY-169849
CAS No.: 1428095-28-6
Target:
Research Areas:
EphA2 antagonist 1 (4b) is a bile acid conjugate and an ephrin type-A receptor 2 (EPHA2) inhibitor .
Cat. No.: HY-W078239
CAS No.: 313701-92-7
Target:
Research Areas:
EPHA4 antagonist-1 (Compound 2) is an EphA4 receptor antagonist. EPHA4 antagonist-1 is also an EphA2 receptor antagonist. EPHA4 antagonist-1 inhibits ephrin-A5 AP binding to EphA4 Fc receptor, with an IC50 of 10 μM .
Cat. No.: HY-163835
Target:
Research Areas:
UniPR1454 targets EphA2 receptor, inhibits the EphA2-ephrin A1 interaction with an IC50 of 2.6 μM. UniPR1454 inhibits the proliferation of glioblastoma cell U251 .
Cat. No.: HY-P11015
Target:
Research Areas:
Cat. No.: HY-171175
CAS No.: 2085767-98-0
Target:
Research Areas:
UniPR500, a UniPR129 derivative, is a competitive EphA2 receptor antagonist with a Ki of 0.78 μM. UniPR500 dose-dependently reduces binding of biotinylated ephrin-A1 to EphA2 with an IC50 value of 1.1 μM .
Cat. No.: HY-157020
Target:
Research Areas:
UniPR1449 is an antagonist of EphA2 receptor, with th KD of 3.8±2.4 μM, that plays an important role in cancer .
Cat. No.: HY-133178R
CAS No.: 131086-98-1
Synonyms: 3,4,8,9-Tetrahydroxy urolithin (Standard)
Category:
Target:
Cat. No.: HY-161170
CAS No.: 2982633-03-2
Antimalarial agent 36 (compound 1) is an antimalarial agent, with the EC50s of 58 nM and 42 nM, for Dd2 and 3D7, respectively. Antimalarial agent 36 targets EphA2 .
Cat. No.: HY-178721
CAS No.: 2768690-22-6
Research Areas:
Lithocholic amide-C2-N(didecane) (Compound LC10) is a Lithocholic acid (HY-B0172) analogue. Lithocholic amide-C2-N(didecane) can form lipid nanoparticles spontaneously in the aqueous milieu, permeate through the skin, penetrate the deeper dermal layers, and exert anti-inflammatory effects against psoriasis-like chronic skin inflammations. Lithocholic amide-C2-N(didecane) can inhibit abnormal proliferation of keratinocytes, downregulate the mRNA expression of the psoriasis-associated receptor EphA2 and reduce serum levels of multiple pro-inflammatory factors such as IL-1α, IL-1β, and IFN-γ by inhibiting activation of the Th17/Th2 inflammatory pathway .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
