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EphA2 receptors

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By Targets:	AMPK (2) Drug Derivative (1) Ephrin Receptor (14) IFNAR (1) Interleukin Related (1) Parasite (1) PPAR (2) Reference Standards (1)
By Research Areas:	Cancer (12) Infection (1) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (1)
Click Chemistry:	TCO (1) Labeling and Fluorescence Imaging (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P991577

DS-8895 DS-8895A	Ephrin Receptor	Cancer
DS-8895(DS-8895A) is an anti-EphA2 monoclonal antibody with specific binding to EphA2 receptors and EphA2-expressing cells. DS-8895, when conjugated with ⁸⁹Zr, ¹¹¹In, or ¹²⁵I, supports molecular imaging of EphA2 expression in xenograft models. DS-8895 allows noninvasive measurement of EphA2 expresssion in tumors in vivo. .

HY-123607

UniPR129	Ephrin Receptor	Neurological Disease Cancer
UniPR129 is a potent and orally active Eph/ephrin antagonist. UniPR129 can inhibit EphA2-ephrin-A1 interaction with an IC₅₀ of 945 nM and a K_i of 370 nM. UniPR129 can inhibit angiogenesis and show antitumor and neuroprotective effect. UniPR129 can be used for the researches of cancer and neurological disease, such as colorectal cancer and optic neuropathy .

HY-147637

EphA2 agonist 1	Ephrin Receptor	Cancer
EphA2 agonist 1 (Compound 7bg) is a potent **EphA2 receptor** agonist. EphA2 agonist 1 shows great potency and selectivity toward EphA2 overexpressed glioblastoma cells and stimulates EphA2 phosphorylation .

HY-P3717

Targefrin	Ephrin Receptor	Cancer
Targefrin is a potent *EphA2*-targeting agent, acts as an antagonist. Targefrin binds EphA2-LBD with 21 nM dissociation constant and an IC₅₀ value of 10.8 nM. Targefrin induces cellular receptor internalization and degradation in several pancreatic cancer cell lines .

HY-133178

Urolithin D 3,4,8,9-Tetrahydroxy urolithin	Ephrin Receptor PPAR AMPK	Metabolic Disease Inflammation/Immunology Cancer
Urolithin D (3,4,8,9-Tetrahydroxy urolithin) is a colonic metabolite of Ellagitannins and a competitive, reversible, and selective antagonist of the **EphA receptor. Urolithin D inhibits EphA2-ephrin-A1 binding with an IC₅₀ of 0.9 μM. Urolithin D is also a potent antioxidant that scavenges free radicals and repairs oxidized DNA damage. Additionally, Urolithin D suppresses triglyceride accumulation and promotes fatty acid oxidation by activating the AMPK** signaling pathway. Urolithin D can be used for research on tumors, metabolic, and inflammatory diseases .

HY-P10579

123B9 1 Publications Verification	Ephrin Receptor	Cancer
123B9, a tumor-homing agent, is a potent and selective *EphA2* agonist with a K_d value of 4.0 μM. 123B9 selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain. 123B9 does not appreciably inhibit the ligand binding domains of the most closely related EphA3 and EphA4 receptors .

HY-169849

EphA2 antagonist 1	Ephrin Receptor	Others
EphA2 antagonist 1 (4b) is a bile acid conjugate and an ephrin type-A receptor 2 (EPHA2) inhibitor .

HY-W078239

EPHA4 antagonist-1	Ephrin Receptor	Cancer
EPHA4 antagonist-1 (Compound 2) is an *EphA4* receptor antagonist. EPHA4 antagonist-1 is also an *EphA2* receptor antagonist. EPHA4 antagonist-1 inhibits ephrin-A5 AP binding to EphA4 Fc receptor, with an IC₅₀ of 10 μM .

HY-163835

UniPR1454	Ephrin Receptor	Cancer
UniPR1454 targets **EphA2 receptor*, inhibits the EphA2-ephrin* A1 interaction with an IC₅₀ of 2.6 μM. UniPR1454 inhibits the proliferation of glioblastoma cell U251 .

HY-P11015

(123B9)2-Motif	Ephrin Receptor	Cancer
(123B9)2-Motif is a selective *EphA2* receptor agonist (K_d=4.9 μM) that does not bind to EphA4. (123B9)2-Motif works by inducing EphA2 receptor phosphorylation and oligomerization, thereby promoting receptor activation and internalization. (123B9)2-Motif is primarily used in targeted drug delivery studies for cancers that overexpress EphA2, such as breast cancer, to reduce circulating tumor cells and inhibit metastasis .

HY-171175

UniPR500	Ephrin Receptor	Cancer
UniPR500, a UniPR129 derivative, is a competitive **EphA2 receptor antagonist with a K_i** of 0.78 μM. UniPR500 dose-dependently reduces binding of biotinylated ephrin-A1 to EphA2 with an IC₅₀ value of 1.1 μM .

HY-157020

UniPR1449	Ephrin Receptor	Cancer
UniPR1449 is an antagonist of EphA2 receptor, with th K_D of 3.8±2.4 μM, that plays an important role in cancer .

HY-133178R

Urolithin D (Standard) 3,4,8,9-Tetrahydroxy urolithin (Standard)	Reference Standards Ephrin Receptor PPAR AMPK	Metabolic Disease Inflammation/Immunology Cancer
Urolithin D (Standard) (3,4,8,9-Tetrahydroxy urolithin (Standard)) is the analytical standard of Urolithin D (HY-133178). This product is intended for research and analytical applications. Urolithin D (3,4,8,9-Tetrahydroxy urolithin) is a colonic metabolite of Ellagitannins and a competitive, reversible, and selective antagonist of the **EphA receptor. Urolithin D inhibits EphA2-ephrin-A1 binding with an IC₅₀ of 0.9 μM. Urolithin D is also a potent antioxidant that scavenges free radicals and repairs oxidized DNA damage. Additionally, Urolithin D suppresses triglyceride accumulation and promotes fatty acid oxidation by activating the AMPK** signaling pathway. Urolithin D can be used for research on tumors, metabolic, and inflammatory diseases .

HY-161170

Antimalarial agent 36	Parasite	Infection
Antimalarial agent 36 (compound 1) is an antimalarial agent, with the EC₅₀s of 58 nM and 42 nM, for Dd2 and 3D7, respectively. Antimalarial agent 36 targets EphA2 .

HY-178721

Lithocholic amide-C2-N(didecane)	Drug Derivative Ephrin Receptor Interleukin Related IFNAR	Inflammation/Immunology
Lithocholic amide-C2-N(didecane) (Compound LC10) is a Lithocholic acid (HY-B0172) analogue. Lithocholic amide-C2-N(didecane) can form lipid nanoparticles spontaneously in the aqueous milieu, permeate through the skin, penetrate the deeper dermal layers, and exert anti-inflammatory effects against psoriasis-like chronic skin inflammations. Lithocholic amide-C2-N(didecane) can inhibit abnormal proliferation of keratinocytes, downregulate the mRNA expression of the psoriasis-associated receptor *EphA2* and reduce serum levels of multiple pro-inflammatory factors such as IL-1α, IL-1β, and IFN-γ by inhibiting activation of the Th17/Th2 inflammatory pathway .

Cat. No.	Product Name	Target	Research Area

HY-P3717

Targefrin	Ephrin Receptor	Cancer
Targefrin is a potent *EphA2*-targeting agent, acts as an antagonist. Targefrin binds EphA2-LBD with 21 nM dissociation constant and an IC₅₀ value of 10.8 nM. Targefrin induces cellular receptor internalization and degradation in several pancreatic cancer cell lines .

HY-P10579

123B9 1 Publications Verification	Ephrin Receptor	Cancer
123B9, a tumor-homing agent, is a potent and selective *EphA2* agonist with a K_d value of 4.0 μM. 123B9 selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain. 123B9 does not appreciably inhibit the ligand binding domains of the most closely related EphA3 and EphA4 receptors .

HY-P11015

(123B9)2-Motif	Ephrin Receptor	Cancer
(123B9)2-Motif is a selective *EphA2* receptor agonist (K_d=4.9 μM) that does not bind to EphA4. (123B9)2-Motif works by inducing EphA2 receptor phosphorylation and oligomerization, thereby promoting receptor activation and internalization. (123B9)2-Motif is primarily used in targeted drug delivery studies for cancers that overexpress EphA2, such as breast cancer, to reduce circulating tumor cells and inhibit metastasis .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991577

DS-8895 DS-8895A	Ephrin Receptor	Cancer
DS-8895(DS-8895A) is an anti-EphA2 monoclonal antibody with specific binding to EphA2 receptors and EphA2-expressing cells. DS-8895, when conjugated with ⁸⁹Zr, ¹¹¹In, or ¹²⁵I, supports molecular imaging of EphA2 expression in xenograft models. DS-8895 allows noninvasive measurement of EphA2 expresssion in tumors in vivo. .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-133178

Urolithin D 3,4,8,9-Tetrahydroxy urolithin	Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Source Classification Cancer	Ephrin Receptor PPAR AMPK
Urolithin D (3,4,8,9-Tetrahydroxy urolithin) is a colonic metabolite of Ellagitannins and a competitive, reversible, and selective antagonist of the **EphA receptor. Urolithin D inhibits EphA2-ephrin-A1 binding with an IC₅₀ of 0.9 μM. Urolithin D is also a potent antioxidant that scavenges free radicals and repairs oxidized DNA damage. Additionally, Urolithin D suppresses triglyceride accumulation and promotes fatty acid oxidation by activating the AMPK** signaling pathway. Urolithin D can be used for research on tumors, metabolic, and inflammatory diseases .

HY-133178R

Urolithin D (Standard) 3,4,8,9-Tetrahydroxy urolithin (Standard)	Microorganisms Phenols Polyphenols Source Classification	Reference Standards Ephrin Receptor PPAR AMPK
Urolithin D (Standard) (3,4,8,9-Tetrahydroxy urolithin (Standard)) is the analytical standard of Urolithin D (HY-133178). This product is intended for research and analytical applications. Urolithin D (3,4,8,9-Tetrahydroxy urolithin) is a colonic metabolite of Ellagitannins and a competitive, reversible, and selective antagonist of the **EphA receptor. Urolithin D inhibits EphA2-ephrin-A1 binding with an IC₅₀ of 0.9 μM. Urolithin D is also a potent antioxidant that scavenges free radicals and repairs oxidized DNA damage. Additionally, Urolithin D suppresses triglyceride accumulation and promotes fatty acid oxidation by activating the AMPK** signaling pathway. Urolithin D can be used for research on tumors, metabolic, and inflammatory diseases .

UniPR1449		Labeling and Fluorescence Imaging TCO
UniPR1449 is an antagonist of EphA2 receptor, with th K_D of 3.8±2.4 μM, that plays an important role in cancer .

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EphA2 receptors

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