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Gibberella fujikuroi

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Ceramidase (1) Drug Derivative (1) Drug Intermediate (2) Endogenous Metabolite (1) Insecticide (1) Phytohormone (1) Reference Standards (1)
By Research Areas:	Cancer (2) Infection (2) Metabolic Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6723

Fumonisin B2	Ceramidase Acyltransferase	Infection Cancer
Fumonisin B2 is a selective ceramide synthase inhibitor and carcinogenic mycotoxin with toxicity comparable to that of Fumonisin B1 (HY-N6719). Fumonisin B2 inhibits de novo sphingolipid biosynthesis by blocking the amide bond formation between fatty acids and dihydrosphingosine, which leads to a massive intracellular accumulation of free dihydrosphingosine, altered sphingosine levels, subsequent inhibition of cell proliferation, and induction of cell death. Fumonisin B2 is used to investigate the pathogenesis of diseases associated with Fusarium verticillioides contamination, including equine leukoencephalomalacia, porcine pulmonary edema syndrome, human esophageal cancer, and rat hepatocellular carcinoma .

HY-N15579

Fujenal	Phytohormone	Cancer
Fujenal is a kaurene-type diterpenoid found in Gibberella fujikuroi. Fujenal shows moderate inhibition against HeLa tumor cells and acts as a gibberellin biosynthesis inhibitor. Fujenal is promising for research of plant growth regulators and antitumor agents .

HY-N15498

Gibepyrone D	Insecticide	Infection
Gibepyrone D is an α-pyrone compound found in Gibberella fujikuroi and the endophytic fungus Fusarium oxysporum 162. Gibepyrone D exhibits significant lethal activity against nematodes with an LC₅₀ value of 134 μg/mL (72 h) against the J2 larvae of Meloidogyne incognita. Gibepyrone D is promising for research of nematicides .

HY-N19707

7β-Hydroxykaurenolide	Drug Intermediate Endogenous Metabolite	Others
7β-Hydroxykaurenolide is a kaurenolide and by-product of Gibberellin biosynthesis, can be found in Gibberella fujikuroi cultures. 7β-Hydroxykaurenolide is a drug intermediate .

HY-N7697BR

Chitobiose dihydrochloride (Standard)	Reference Standards Others	Others
Gibberellic acid (Standard) is the analytical standard of Gibberellic acid. This product is intended for research and analytical applications. Gibberellic Acid is named after the fungus Gibberella fujikuroi. Gibberellic Acid regulates processes in plant development and growth, including seed development and germination, stem and root growth, cell division, and flowering time. Gibberellic Acid also improves plant response to growth stress caused by various environmental stresses, such as cold stress, drought stress, heavy metal stress, etc. Gibberellic Acid also causes increased lipid peroxidation and fluctuations in the antioxidant defense system in rats .

HY-N18338

Steviol-15-ene	Drug Derivative	Others
Steviol-15-ene is a Δ ¹⁵-double bond isomer of steviol, a tetracyclic diterpenoid. Steviol-15-ene undergoes 7β-hydroxylation by Gibberella fujikuroi to form methyl ent-7α,13-dihydroxykaur-15-en-19-oate .

HY-N10619

Gibberellin A12	Drug Intermediate	Metabolic Disease
Gibberellin A₁₂ is a free C₂₀-gibberellin, serving as a gibberellin biosynthesis intermediate and metabolite precursor. Gibberellin A₁₂ exists in maturing Sechium edule seed testa, developing Pisum sativum seeds and Gibberella fujikuroi .

Fumonisin B2	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Endogenous metabolite Disease Research Fields Other Antibiotics Source Classification	Ceramidase Acyltransferase
Fumonisin B2 is a selective ceramide synthase inhibitor and carcinogenic mycotoxin with toxicity comparable to that of Fumonisin B1 (HY-N6719). Fumonisin B2 inhibits de novo sphingolipid biosynthesis by blocking the amide bond formation between fatty acids and dihydrosphingosine, which leads to a massive intracellular accumulation of free dihydrosphingosine, altered sphingosine levels, subsequent inhibition of cell proliferation, and induction of cell death. Fumonisin B2 is used to investigate the pathogenesis of diseases associated with Fusarium verticillioides contamination, including equine leukoencephalomalacia, porcine pulmonary edema syndrome, human esophageal cancer, and rat hepatocellular carcinoma .

Fujenal	Microorganisms Terpenoids Diterpenoids Source Classification	Phytohormone
Fujenal is a kaurene-type diterpenoid found in Gibberella fujikuroi. Fujenal shows moderate inhibition against HeLa tumor cells and acts as a gibberellin biosynthesis inhibitor. Fujenal is promising for research of plant growth regulators and antitumor agents .

Gibepyrone D	Microorganisms Ketones, Aldehydes, Acids Source Classification	Insecticide
Gibepyrone D is an α-pyrone compound found in Gibberella fujikuroi and the endophytic fungus Fusarium oxysporum 162. Gibepyrone D exhibits significant lethal activity against nematodes with an LC₅₀ value of 134 μg/mL (72 h) against the J2 larvae of Meloidogyne incognita. Gibepyrone D is promising for research of nematicides .

7β-Hydroxykaurenolide	Structural Classification Terpenoids Cucurbita maxima Duch. ex Lam. Cucurbitaceae Diterpenoids Plants Source Classification	Drug Intermediate Endogenous Metabolite
7β-Hydroxykaurenolide is a kaurenolide and by-product of Gibberellin biosynthesis, can be found in Gibberella fujikuroi cultures. 7β-Hydroxykaurenolide is a drug intermediate .

Chitobiose dihydrochloride (Standard)	Structural Classification Microorganisms Saccharides Source Classification	Reference Standards Others
Gibberellic acid (Standard) is the analytical standard of Gibberellic acid. This product is intended for research and analytical applications. Gibberellic Acid is named after the fungus Gibberella fujikuroi. Gibberellic Acid regulates processes in plant development and growth, including seed development and germination, stem and root growth, cell division, and flowering time. Gibberellic Acid also improves plant response to growth stress caused by various environmental stresses, such as cold stress, drought stress, heavy metal stress, etc. Gibberellic Acid also causes increased lipid peroxidation and fluctuations in the antioxidant defense system in rats .

Steviol-15-ene	Structural Classification Microorganisms Terpenoids Diterpenoids Source Classification	Drug Derivative
Steviol-15-ene is a Δ ¹⁵-double bond isomer of steviol, a tetracyclic diterpenoid. Steviol-15-ene undergoes 7β-hydroxylation by Gibberella fujikuroi to form methyl ent-7α,13-dihydroxykaur-15-en-19-oate .

Gibberellin A12	Structural Classification Sechium edule (Jacq.) Sw. Ketones, Aldehydes, Acids Cucurbitaceae Plants Source Classification	Drug Intermediate
Gibberellin A₁₂ is a free C₂₀-gibberellin, serving as a gibberellin biosynthesis intermediate and metabolite precursor. Gibberellin A₁₂ exists in maturing Sechium edule seed testa, developing Pisum sativum seeds and Gibberella fujikuroi .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Gibberella fujikuroi

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NaturalProducts

Natural
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