Gibberellin A12 

Gibberellin A₁₂ is a free C₂₀-gibberellin, serving as a gibberellin biosynthesis intermediate and metabolite precursor. Gibberellin A₁₂ exists in maturing Sechium edule seed testa, developing Pisum sativum seeds and Gibberella fujikuroi^[1][2][3][4].

Gibberellin A₁₂ is present as a free compound in the testa of maturing Sechium edule seeds, and is absent from the embryo and endosperm of these seeds^[1].
Gibberellin A₁₂ (0.064-1.0 mM MVA; 2-4 h) is synthesized from MVA by cell-free extracts from Cucurbita maxima liquid endosperm with an apparent K_m of 0.4 mM MVA, achieving up to 7% incorporation of MVA into GA₁₂^[2].
Gibberellin A₁₂ exists in developing Pisum sativum L. seeds, and can be enzymatically synthesized from mevalonic acid with definite specific activity and production efficiency^[3].
Gibberellin A12 (0.2 μCi; 1-24 h) is rapidly and exclusively metabolized by cotyledons from 20-day-old Pisum sativum L. G2 seeds to 13-hydroxylated gibberellins^[4].
Gibberellin A12 (0.2 μCi; 3-24 h) is slowly metabolized by seed coats from 20-day-old Pisum sativum L. G2 seeds to both 13-hydroxylated and non-13-hydroxylated gibberellins^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

332.43

C₂₀H₂₈O₄

1164-45-0

Solid

OC([C@@H]1[C@]23[C@](CC[C@](C(C3)=C)([H])C2)([H])[C@]4([C@@]1([H])[C@@](C)(CCC4)C(O)=O)C)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Albone KS, et al. Identification and localization of gibberellins in maturing seeds of the cucurbit Sechium edule, and a comparison between this cucurbit and the legume Phaseolus coccineus. Planta. 1984;162(6):560-565.

  [2]. Birnberg PR, et al. An improved enzymatic synthesis of labeled gibberellin A12-aldehyde and gibberellin A12. Anal Biochem. 1986;153(1):1-8.

  [3]. Zhu YX, et al. Gibberellin A12 and gibberellin A12-7-aldehyde as endogenous compounds in developing seeds Pisum sativum. Phytochemistry. 1988;27(7):2025-2029.

  [4]. Zhu YX, et al. Metabolism of Gibberellin A(12) and A(12)-Aldehyde in Developing Seeds of Pisum sativum L. Plant Physiol. 1991 Sep;97(1):26-33.