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Results for "

HD

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Amino Acid Derivatives (3) Angiotensin-converting Enzyme (ACE) (2) Apoptosis (6) Atg8/LC3 (2) ATP Synthase (1) Autophagy (3) Bacterial (6) Biochemical Assay Reagents (2) Calpain (1) Carnitine Palmitoyltransferase (CPT) (1) Caspase (5) Cathepsin (1) ClpP (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Dopamine Receptor (30) Drug Derivative (1) Drug Metabolite (2) Dynamin (1) Endogenous Metabolite (3) Epigenetic Reader Domain (1) Eukaryotic Initiation Factor (eIF) (1) GABA Receptor (1) Glucocorticoid Receptor (1) Glutaminase (3) HDAC (6) Herbicide (1) Histamine Receptor (5) HIV (2) Huntingtin (6) Isotope-Labeled Compounds (11) JAK (1) MHC (1) Microtubule/Tubulin (1) MNK (1) Monoamine Transporter (6) PD-1/PD-L1 (1) Potassium Channel (2) PPAR (1) PROTACs (5) Reference Standards (6) SARS-CoV (2) Sirtuin (1) Small Interfering RNA (siRNA) (4) Sodium Channel (1) STAT (1) Stearoyl-CoA Desaturase (SCD) (1) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (14) Infection (4) Inflammation/Immunology (7) Metabolic Disease (2) Neurological Disease (50)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Cationic Lipids (1) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (1) Antisense Oligonucleotides (3) siRNAs (4)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0623A

Ropinirole hydrochloride 3 Publications Verification SKF 101468 hydrochloride	Dopamine Receptor	Neurological Disease
Ropinirole (SKF 101468) hydrochloride is an orally active, potent D₃/D₂ receptor agonist with a K_i of 29 nM for D₂ receptor. Ropinirole hydrochloride has pEC₅₀s of 7.4, 8.4 and 6.8 for hD₂, hD₃ and hD₄ receptors, respectively. Ropinirole hydrochloride has no affinity for the D₁ receptors. Ropinirole hydrochloride has the potential for Parkinson's disease .

HY-124476

Cystamine 5 Publications Verification	Caspase Glutaminase Apoptosis	Cancer
Cystamine is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC₅₀ value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) .

HY-B0590

Tetrabenazine 1 Publications Verification Ro 1-9569	Monoamine Transporter Dopamine Receptor	Neurological Disease
Tetrabenazine (Ro 1-9569) is a brain-penetrant and orally active VMAT2-selective ligand with human VMAT2 K_i 100 nM. Tetrabenazine binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine weakly blocks dopamine D2 receptors, and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome .

HY-16482

Teglicar 3 Publications Verification	Carnitine Palmitoyltransferase (CPT) Endogenous Metabolite	Neurological Disease Metabolic Disease
Teglicar is a selective and reversible orally active liver isoform of carnitine palmitoyl-transferase 1 (L-CPT1) inhibitor with an IC₅₀ value of 0.68 μM and a K_i value of 0.36 μM. Teglicar has a potential antihyperglycemic propert. Teglicar can be used for the research of diabetes and neurodegenerative disease including Huntington's disease (HD) .

HY-B0590S

Tetrabenazine-d6 Ro 1-9569-d₆	Monoamine Transporter	Neurological Disease
Tetrabenazine-d₆ (Deutetrabenazine) is a deuterium-labled Tetrabenazine (HY-B0590). Tetrabenazine (Ro 1-9569) is a brain-penetrant and orally active VMAT2-selective ligand with human VMAT2 K_i 100 nM. Tetrabenazine binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine weakly blocks dopamine D2 receptors, and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome .

HY-B0248

Desonide 2 Publications Verification	Glucocorticoid Receptor Huntingtin Apoptosis	Neurological Disease Inflammation/Immunology
Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. Desonide can also specifically bind to the mutant huntingtin protein (mHTT), reducing the level and toxicity of mHTT. Desonide can be used in the research of Huntington's disease and inflammatory diseases such as atopic dermatitis .

HY-W020050

Cystamine dihydrochloride 5 Publications Verification	Caspase Glutaminase Apoptosis	Neurological Disease Cancer
Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC₅₀ value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) .

HY-130259

LC3-mHTT-IN-AN2	Atg8/LC3 Autophagy	Neurological Disease
LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons .

HY-B0274

Chlorprothixene 2 Publications Verification	Dopamine Receptor Histamine Receptor Bacterial	Neurological Disease
Chlorprothixene is a dopamine and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity .

HY-B0274A

Chlorprothixene hydrochloride 2 Publications Verification	Dopamine Receptor Histamine Receptor Bacterial	Neurological Disease
Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity .

HY-130258

LC3-mHTT-IN-AN1	Atg8/LC3 Autophagy	Neurological Disease
LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons .

HY-P0111

Z-WEHD-FMK 4 Publications Verification Z-WE(OMe)HD(OMe)-FMK	Caspase Cathepsin	Cancer
Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC₅₀=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis .

HY-100384

NKL 22 1 Publications Verification	HDAC	Neurological Disease Cancer
NKL 22 is a potent and selective inhibitor of histone deacetylases (HDAC), with IC₅₀ values of 199 and 69 nM for HDAC1 and HDAC3, respectively. NKL 22 can reverse abnormal expression of HD‑related genes and restore the levels of key genes including Ppp1r1b in Huntington's disease transgenic mice. NKL 22 can be used for the researches of Huntington's disease and cancer .

HY-101382

GR 103691 2 Publications Verification	Dopamine Receptor	Neurological Disease
GR 103691 is a potent, selective dopamine D₃ receptor antagonist with a K_i value of 0.4 nM. GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D₃ over hD₄ and hD₁ sites .

HY-172199

THX6	ClpP	Cancer
THX6 is an hClpP activator with an EC₅₀ of 1.18 μM. THX6 improves off-target profile with no affinity for hD2R and only weak affinity for hD3R (K_i = 51.1 µM) in HEK293 cells. THX6 shows good cytotoxicity in ONC201-resistant cells with an IC₅₀ of 0.13 μM. THX6 changes the levels of fatty acids (PUFAs, MUFAs, and SFAs) in DIPG cells. THX6 decreases the level of proteins involved in oxidative phosphorylation, biogenesis, and mitophagy proteins, thereby resulting in a global collapse of mitochondrial integrity and function. THX6 can be used for diffuse intrinsic pontine glioma research .

HY-132579

Tominersen RG6042; IONIS-HTTRx	Huntingtin	Neurological Disease
Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD) .

HY-B0590A

Tetrabenazine Racemate Ro 1-9569 Racemate	Monoamine Transporter Dopamine Receptor	Neurological Disease
Tetrabenazine (Ro 1-9569) Racemate is a brain-penetrant and orally active VMAT2-selective ligand with human VMAT2 K_i 100 nM. Tetrabenazine Racemate binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine Racemate weakly blocks dopamine D2 receptors, and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine Racemate can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome .

HY-146346

HD-TAC7	PROTACs HDAC	Inflammation/Immunology
HD-TAC7 is a potent PROTAC HDAC degrader with IC₅₀ values of 3.6 μM, 4.2 μM and 1.1 μM for HDAC1, HDAC2 and HDAC3, respectively. HD-TAC7 can decreases NF-κB p65 in RAW 264.7 macrophages. HD-TAC7 can be used for the research of inflammatory diseases like asthma and chronic obstructive pulmonary disease (COPD) .

HY-Y0315

Hexane-2,5-dione 2,5-HD	Drug Metabolite	Neurological Disease
Hexane-2,5-dione (2,5-HD) is a cytotoxic agent. Hexane-2,5-dione causes an accumulation of neurofilaments within axons in rats that may lead to their degeneration. Hexane-2,5-dione is promising for research of neurodegenerative diseases (e.g., Alzheimer's, Parkinson's) .

HY-B0623

Ropinirole 3 Publications Verification SKF 101468	Dopamine Receptor	Neurological Disease
Ropinirole (SKF 101468) is an orally active, potent D₃/D₂ receptor agonist with a K_i of 29 nM for D₂ receptor. Ropinirole has pEC₅₀s of 7.4, 8.4 and 6.8 for hD₂, hD₃ and hD₄ receptors, respectively. Ropinirole has no affinity for the D₁ receptors. Ropinirole has the potential for Parkinson's disease .

HY-147398

Dopamine D4 receptor antagonist-1	Dopamine Receptor	Neurological Disease
Dopamine D4 receptor antagonist-1 is a selective DRD4 antagonists, with a K_i of 9.0 nM for *Hd4.2*. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia .

HY-W009062

MePhos	Biochemical Assay Reagents	Others
MePhos is an o-BPP ligand. The combination of MePhos and silver carbonate serves as a catalyst for H/D exchange reactions .

HY-132579A

Tominersen sodium RG6042 sodium; IONIS-HTTRx sodium	Huntingtin	Neurological Disease
Tominersen sodium is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen sodium can be used for the research of Huntington’s disease (HD) .

HY-156278

FB49	Apoptosis Autophagy	Cancer
FB49 is a highly selective inhibitor of Bcl-2-associated athanogene 3 (BAG3), with the K_i of 45 μM. FB49 inhibits the cell growth in human tumoral cells, but has no toxicity in human peripheral mononuclear cells. FB49 block cell cycle in G1 phase and to induce apoptosis as well as autophagy in medulloblastoma HD-MB03 treated cells .

HY-75070

(+)-1-(1-Naphthyl)ethylamine	Biochemical Assay Reagents	Others
(+)-1-(1-Naphthyl)ethylamine ((+)-1-(1-NEA)) is a chiral modifier used to introduce enantioselectivity in catalytic hydrogenation reactions. 1-NEA can undergo H-D exchange with D2 in solution to form N?D bonds. That is, 1-NEA can complete Pt surface adsorption and protonation through amine N atoms, indicating that NEA molecules have the potential to impart enantioselectivity to Pt hydrogenation catalysts .

HY-P5407

HD5	SARS-CoV Angiotensin-converting Enzyme (ACE)	Infection Cancer
HD5 is an innate immune effector peptide and SARS-CoV Inhibitor. HD5 binds to the ligand-binding domain of angiotensin-converting enzyme-2 (ACE2) via multiple hydrogen bonds to competitively block the receptor, shielding it from viral recognition. HD5 can be used for the research of COVID-19, HPV16 infection, epithelial ovarian cancer, small-cell lung cancer, and colon cancer .

HY-P11005

P259	Dynamin ATP Synthase	Neurological Disease
P259 is a Drp1-Mff inhibitor. P259 distinguishes physiological from pathological fission by specifically inhibiting Drp1-Mff interaction. P259 elongates cell mitochondria and disrupts mitochondrial function and motility. P259 reduces ATP levels and alters mitochondrial structure in the brain, resulting in behavioral deficits in wild-type mice and a short lifespan in Huntington's disease (HD) mice model .

HY-B1899S

Taurodeoxycholic acid-d5 Taurodeoxycholate-d₅	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis	Others
Taurodeoxycholic acid-d₅ is the deuterium labeled Taurodeoxycholic acid (HY-B1899) . Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD) .

HY-156103

mHTT-IN-2	Huntingtin	Neurological Disease
mHTT-IN-2 (compound 27) is a potent inhibitor (EC₅₀=0.066 μM) of mutant huntingtin (mHTT). mHTT-IN-2 reduces canonical splicing of HTT RNA exons [49-50] and is a splicing regulator of the huntingtin (HTT) gene. mHTT-IN-2 exhibits inhibitory activity in vitro and in vivo in human HD stem cells and mouse BACHD models. mHTT-IN-2 may be used in the study of branaplam-related peripheral neuropathy .

HY-155941

5-Hydroxydecanoic acid	Potassium Channel	Neurological Disease
5-Hydroxydecanoic acid (5-HD） is a K_ATP channel antagonist，which has the effect of blocking the K K_ATP channel only during ischaemia by competing with the ATP binding site and does not affect pancreatic K_ATP channels .

HY-W008269

H-D-2-Nal-OH	Amino Acid Derivatives	Others
H-D-2-Nal-OH is an alanine derivative .

HY-14328

Sonepiprazole PNU-101387G; U-101387G	Dopamine Receptor	Neurological Disease
Sonepiprazole (PNU-101387G) is a selective D4 dopamine antagonist with K_is of 3.6, 10.1, 5147, and 7430 nM for rD4-Dopamine, hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 receptors, respectively .

HY-14782

Adoprazine SLV313	5-HT Receptor Dopamine Receptor	Neurological Disease
Adoprazine (SLV313) is a full 5-HT_1A receptor agonist with a pEC₅₀ of 9 at cloned h5-HT_1A receptors. Adoprazine (SLV313) is a full D₂ and D₃ receptor antagonist with pA₂s of 9.3 and 8.9 at hD₂ and hD₃ receptors, respectively. Adoprazine (SLV313) has the characteristics of atypical antipsychotics .

HY-136373S

Metazachlor-d6 BAS 479H-d₆	Isotope-Labeled Compounds Herbicide Cytochrome P450 DNA/RNA Synthesis	Others
Metazachlor-d₆ (BAS 479H-d₆) is a deuterium labeled Metazachlor (HY-136373). Metazachlor (BAS 479H) is a herbicide belonging to the chloroacetamides class. Metazachlor can inhibit the synthesis of very long chain fatty acids during the germination and emergence of weed seeds, thereby interfering with cell division and tissue differentiation, and thus hindering the normal growth and development of weeds .

HY-111560

IQM-266	Potassium Channel	Neurological Disease
IQM-266 is a Downstream Regulatory Element Antagonist Modulator (DREAM) ligand with a K_D of 4.63 μM. IQM-266 inhibits the K_V4.3/DREAM current in a concentration-, voltage-, and time-dependent-manner. IQM-266 also modulates A-type outward potassium currents (IA) from rat dorsal root ganglia (DRG) neurons. IQM-266 can be used for neurological disease research, such as Alzheimer’s disease and Huntington's disease (HD) .

HY-101065

AJ-76 hydrochloride (+)-AJ 76 hydrochloride; (1S,2R)-AJ 76 hydrochloride	Dopamine Receptor	Others
AJ-76 hydrochloride ((+)-AJ 76 hydrochloride) is an antagonist of dopamine autoreceptor with pK_i values of 6.95, 6.67, 6.37, 6.21 and 6.07 for hD3, hD4, hD2S, hD2L and rD2 receptors, respectively.

HY-W022404

H-D-4-Pal-OH.2HCl	Amino Acid Derivatives	Others
H-D-4-Pal-OH.2HCl is an alanine derivative .

HY-47822

WAY-354574	Sirtuin	Neurological Disease
WAY-354574 is an active molecule targeting deacetylase (Sirtuin) for the study of Huntington's disease (HD) .

HY-170900

SJ44236	PROTACs Epigenetic Reader Domain	Cancer
SJ44236 is the PROTAC degrader for BET that degrades BRD2 (DC₅₀ = 0.127 nM), BRD3 and BRD4. SJ44236 exhibits cytotoxicity in cell MV4-11 and HD-MB03 with IC₅₀s of 0.12 nM and 0.92 nM. SJ44236 downregulates the expression of c-Myc, upregulates the expression of p53. SJ44236 exhibits a good orally bioavailability of 45% in mice . (Pink: ligand for target protein JQ-1 carboxylic acid (HY-78695); Black: linker (HY-W012935); Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 54 (HY-W890189))

HY-137613

Sp-TTPαS	HIV	Infection Inflammation/Immunology
Sp-TTPαS is a competitivesterile alpha motif and HD domain containing protein 1 (SAMHD1) hydrolysis inhibitor. Sp-TTPαS competitively inhibits SAMHD1 triphosphohydrolase activity with a K_i value of 46 µM .

HY-150245

mHTT-IN-1	Huntingtin	Neurological Disease
mHTT-IN-1 (Example 1) is a potent mutant huntingtin (mHTT) inhibitor. mHTT is toxic and a major cause of the inherited autosomal dominant neurodegenerative disorder, Huntington's disease (HD). mHTT-IN-1 conducts the reduction of mHTT with an EC₅₀ value of 46 nM .

HY-Y0315S

2,5-Hexanedione-d10 2,5-HD-d₁₀	Isotope-Labeled Compounds	Others
2,5-Hexanedione-d₁₀ is the deuterium labeled 2,5-Hexanedione .

HY-155396

PRO-HD1	PROTACs HDAC	Cancer
PRO-HD1 is a PROTAC HDAC6 degrader. PRO-HD1 degrades HDAC6 in A549 cells, and inhibits proliferation of Jurkat cells (IC₅₀: 5.8 μM) .

HY-N10398

Garcinielliptone HD	Others	Others
Garcinielliptone HD is a compound isolated from the heartwood of Garcinia subelliptica Merr. .

HY-155398

PRO-HD3	PROTACs HDAC	Cancer
PRO-HD3 is a cell-specific, PROTAC-based HDAC6 degrader .

HY-155397

PRO-HD2	PROTACs HDAC	Cancer
PRO-HD2 is a cell-specific, PROTAC-based HDAC6 degrader .

HY-P5790

μ-TRTX-Hd1a	Sodium Channel	Neurological Disease
μ-TRTX-Hd1a, a spider venom, is a selective NaV 1.7 inhibitor. μ-TRTX-Hd1a is a gating modifier that inhibits human NaV 1.7 by interacting with the S3b-S4 paddle motif in channel domain II .

HY-RS24494

Htt Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Htt Rat Pre-designed siRNA Set A contains three designed siRNAs for Htt gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Htt Rat Pre-designed siRNA Set A Htt Rat Pre-designed siRNA Set A

HY-B0274AS

Chlorprothixene-d6 hydrochloride	Isotope-Labeled Compounds Dopamine Receptor Histamine Receptor Bacterial	Neurological Disease
Chlorprothixene-d₆ hydrochloride is the deuterium labeled Chlorprothixene hydrochloride. Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity .

HY-B0274R

Chlorprothixene (Standard)	Reference Standards Dopamine Receptor Histamine Receptor Bacterial	Neurological Disease
Chlorprothixene (Standard) is the analytical standard of Chlorprothixene. This product is intended for research and analytical applications. Chlorprothixene is a dopamine and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16482

Teglicar 3 Publications Verification	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Carnitine Palmitoyltransferase (CPT) Endogenous Metabolite
Teglicar is a selective and reversible orally active liver isoform of carnitine palmitoyl-transferase 1 (L-CPT1) inhibitor with an IC₅₀ value of 0.68 μM and a K_i value of 0.36 μM. Teglicar has a potential antihyperglycemic propert. Teglicar can be used for the research of diabetes and neurodegenerative disease including Huntington's disease (HD) .

HY-130259

LC3-mHTT-IN-AN2	other families Coumarins Phenols Polyphenols Phenylpropanoids Plants Source Classification	Atg8/LC3 Autophagy
LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons .

HY-N10398

Garcinielliptone HD	Quinones Structural Classification Classification of Application Fields Guttiferae Other Diseases Benzene Quinones Plants Garcinia subelliptica Disease Research Fields Source Classification	Others
Garcinielliptone HD is a compound isolated from the heartwood of Garcinia subelliptica Merr. .

HY-N17655

Neonootkatol	Structural Classification Monophenols Rubiaceae Phenols Plants Oldenlandia corymbosa L. Source Classification	Endogenous Metabolite
Neonootkatol is an alcoholic secondary metabolite that can be found in Hedyotis diffusa (HD) and Hedyotis corymbosa (HC) .

Cat. No.	Product Name	Chemical Structure

HY-B0590S

Tetrabenazine-d6

Tetrabenazine-d₆ (Deutetrabenazine) is a deuterium-labled Tetrabenazine (HY-B0590). Tetrabenazine (Ro 1-9569) is a brain-penetrant and orally active VMAT2-selective ligand with human VMAT2 K_i 100 nM. Tetrabenazine binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine weakly blocks dopamine D2 receptors, and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome .

HY-B1899S

Taurodeoxycholic acid-d5

Taurodeoxycholic acid-d₅ is the deuterium labeled Taurodeoxycholic acid (HY-B1899) . Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD) .

HY-136373S

Metazachlor-d6

Metazachlor-d₆ (BAS 479H-d₆) is a deuterium labeled Metazachlor (HY-136373). Metazachlor (BAS 479H) is a herbicide belonging to the chloroacetamides class. Metazachlor can inhibit the synthesis of very long chain fatty acids during the germination and emergence of weed seeds, thereby interfering with cell division and tissue differentiation, and thus hindering the normal growth and development of weeds .

HY-Y0315S

2,5-Hexanedione-d10
2,5-Hexanedione-d₁₀ is the deuterium labeled 2,5-Hexanedione .

HY-B0274AS

Chlorprothixene-d6 hydrochloride
Chlorprothixene-d₆ hydrochloride is the deuterium labeled Chlorprothixene hydrochloride. Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity .

HY-B0623AS2

Ropinirole-d3 hydrochloride

Ropinirole-d₃ hydrochloride is the deuterium labeled Ropinirole hydrochloride . Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a K_i of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC₅₀s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease .

HY-B0623AS1

Ropinirole-d7 hydrochloride

Ropinirole-d₇ hydrochloride is the deuterium labeled Ropinirole hydrochloride . Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a K_i of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC₅₀s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease .

HY-B0623AS

Ropinirole-d4 hydrochloride

Ropinirole-d₄ (SKF 101468-d₄) hydrochloride is the deuterium labeled Ropinirole hydrochloride. Ropinirole hydrochloride is a potent D3/D2 receptor agonist with a K_iof 29 nM for D2 receptor. Ropinirole hydrochloride has pEC₅₀s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease .

HY-B0623AS3

Ropinirole-d14 hydrochloride

Ropinirole-d₁₄ hydrochloride is deuterated labeled Ropinirole hydrochloride (HY-B0623A). Ropinirole (SKF 101468) hydrochloride is an orally active, potent D₃/D₂ receptor agonist with a K_i of 29 nM for D₂ receptor. Ropinirole hydrochloride has pEC₅₀s of 7.4, 8.4 and 6.8 for hD₂, hD₃ and hD₄ receptors, respectively. Ropinirole hydrochloride has no affinity for the D₁ receptors. Ropinirole hydrochloride has the potential for Parkinson's disease .

HY-B0623S1

Ropinirole-d3

Ropinirole-d₃ (SKF 101468-d₃) is deuterium labeled Ropinirole. Ropinirole (SKF 101468) is an orally active, potent D₃/D₂ receptor agonist with a K_i of 29 nM for D₂ receptor. Ropinirole has pEC₅₀s of 7.4, 8.4 and 6.8 for hD₂, hD₃ and hD₄ receptors, respectively. Ropinirole has no affinity for the D₁ receptors. Ropinirole has the potential for Parkinson's disease .

HY-143907S

Atorvastatin EP impurity H-d5
Atorvastatin EP impurity H-d₅ is the deuterium labeled Atorvastatin EP impurity H .

HY-W020050S

Cystamine-d8 dihydrochloride

Cystamine-d₈ (dihydrochloride） is the deuterium labeled Cystamine (dihydrochloride） . Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC₅₀ value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) .

HY-B0590S3

Tetrabenazine-d7

Tetrabenazine-d₇ (TBZ-d₇-d₇) is deuterium labeled Tetrabenazine (HY-B0590). Tetrabenazine (Ro 1-9569) is a brain-penetrant and orally active VMAT2-selective ligand with human VMAT2 K_i 100 nM. Tetrabenazine binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine weakly blocks dopamine D2 receptors, and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome .

HY-Z1489S

Moxifloxacin ethyl ester-d5
Moxifloxacin ethyl ester-d₅ (Moxifloxacin impurity H-d₅) is the deuterium labeled Moxifloxacin ethyl ester.

HY-W709982

12-Deoxy roxithromycin-d7
12-Deoxy roxithromycin-d₇ (Roxithromycin impurity H-d₇) is the deuterium labeled 12-Deoxy roxithromycin.

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