56-17-7
56-17-7
Chemical Structure
Cystamine dihydrochloride
- CAS No.: 56-17-7
- Formula:C4H14Cl2N2S2
- Molecular Weight:225.20
IUPAC Name: 2,2'-disulfanediylbis(ethan-1-amine) dihydrochloride
InChIKey: YUFRRMZSSPQMOS-UHFFFAOYSA-N
SMILES: NCCSSCCN.[H]Cl.[H]Cl
Biological Activity: Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) [1][2][3].
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Cystamine dihydrochloride | 99.92% | Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) . | ||||||||||||||||||||
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References
- [1]. Mathieu Lesort, et al. Cystamine inhibits caspase activity. Implications for the treatment of polyglutamine disorders. J Biol Chem. 2003 Feb 7;278(6):3825-30. [Content Brief]
- [2]. Alpaslan Dedeoglu, et al. Therapeutic effects of cystamine in a murine model of Huntington's disease. J Neurosci. 2002 Oct 15;22(20):8942-50. [Content Brief]
- [3]. Thomas M Jeitner, et al. Cystamine and cysteamine as inhibitors of transglutaminase activity in vivo. Biosci Rep. 2018 Sep 5;38(5):BSR20180691. [Content Brief]
Keywords
