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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
HER2-targeting
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "HER2-targeting" in MCE Product Catalog:
14
14 Publications Verification
Synonyms: Exatecan derivative for ADC
Target:
Research Areas:
DXd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
7
7 Cited Publications
Cat. No.: HY-P9921
CAS No.: 1018448-65-1
Synonyms: Ado-Trastuzumab emtansine; PRO132365; T-DM 1
7
7 Cited Publications
Cat. No.: HY-P9921A
CAS No.: 1018448-65-1
Synonyms: Ado-Trastuzumab emtansine (solution); PRO132365 (solution); T-DM 1 (solution)
5
Target:
Research Areas:
Disitamab vedotin (RC48) is a HER2-targeted antibody-drug conjugate (ADC), formed by conjugation of the humanized anti-HER2 antibody Disitamab (HY-P99854) with drug-linker VcMMAE (HY-15575). VcMMAE consists of a cleavable MC-Val-Cit-PAB linker and the microtubule inhibitor MMAE (HY-15162). After binding to HER2 and undergoing endocytosis, Disitamab vedotin releases MMAE in lysosomes, which further inhibits microtubule assembly, arrests mitosis and induces apoptosis, while also exerting a bystander effect. Disitamab vedotin can be used in studies of HER2-positive breast cancer [2] .
1
1 Cited Publications
Synonyms: Lys-Nε-MCC-DM1
Target:
Research Areas:
Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a agent-linker conjugates for ADC that can inhibit tubulin polymerization. Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is a HER2-targeting ADC with a tubulin polymerization inhibitor DM1. Lys-SMCC-DM1 can be used in the research of breast cancer [2].
Cat. No.: HY-13631DS
Purity: 98.84%
Synonyms: Exatecan-d5 derivative for ADC
Cat. No.: HY-164202
Target:
Research Areas:
ORM-5029 is a first-in-class human epidermal growth factor receptor 2 (HER2)-targeted antibody-drug conjugate (ADC) comprised of SMol006, a highly potent GSPT1 degrader, conjugated to Pertuzumab (HY-P9912). ORM-5029 exhibits robust efficacy across 14 HER2-positive breast cancer cell lines, with IC50 values ranging from 0.3 to 14.4 nM.ORM-5029 demonstrates anti-tumor activity in the BT474 xenograft model. ORM-5029 can be used for study of breast cancer [2] .
Cat. No.: HY-P99547
CAS No.: 1642152-40-6
Synonyms: (vic)-Trastuzumab duocarmazine
Target:
Research Areas:
Cat. No.: HY-164762
CAS No.: 2924909-11-3
Synonyms: SHR-A1811
Cat. No.: HY-P991238
Target:
Research Areas:
Cat. No.: HY-P99630
CAS No.: 1509928-00-0
Synonyms: MM-302 antibody
Cat. No.: HY-164763
Target:
Research Areas:
SHR-A1201 is a HER2-targeting antibody-drug conjugate (ADC). SHR-A1201 is composed of a humanized anti-HER2 antibody (HY-P9907), a linker SMCC (HY-42360), and a microtubulin inhibitor payload Mertansine (HY-19792). SHR-A1201 can be used for research in HER2-positive breast cancer .
Cat. No.: HY-P10792
CAS No.: 1644155-35-0
Cat. No.: HY-176976
CAS No.: 3076725-05-5
Target:
Research Areas:
Exatecan-mpGNNG (Compound 10a) is the linker-payload component of an antibody-drug conjugate (ADC). Exatecan-mpGNNG is composed of Exatecan (HY-13631), a potent topoisomerase I inhibitor, and the linker .
Cat. No.: HY-P10648
CAS No.: 3027722-28-4
Synonyms: HER2-targeting peptide
Cat. No.: HY-168285
CAS No.: 2718125-83-6
Research Areas:
LE01 is a drug-linker conjugate for ADC. LE01 contains a ADC linker and a DNA topoisomerase I inhibitor DXd (HY-13631D). LE01 can be used to synthesize HER2-targeting ADC (HER2-LE01) .
Cat. No.: HY-P2548
CAS No.: 176042-83-4
Cat. No.: HY-13631DS1
CAS No.: 2760715-90-8
Synonyms: Exatecan derivative for ADC-d2
Cat. No.: HY-P11760
CAS No.: 1802710-54-8
Cat. No.: HY-P991977
Synonyms: 5G9
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
