2760715-90-8
2760715-90-8
Chemical Structure
DXd-d2
Synonym(s): Exatecan derivative for ADC-d2
- CAS No.: 2760715-90-8
- Formula:C26H22D2FN3O6
- Molecular Weight:495.50
InChIKey: PLXLYXLUCNZSAA-SEPCXYQLSA-N
SMILES: OC([2H])([2H])C(N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)=O
Biological Activity: DXd-d22 (Exatecan derivative for ADC-d2) is the deuterated-labeled DXd (HY-13631D). DXd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
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DXd-d2 | 99.71% | DXd-d22 (Exatecan derivative for ADC-d2) is the deuterated-labeled DXd (HY-13631D). DXd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). | ||||||||||||||||||||
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DXd-d5 | 99.57% | DXd-d5 is a deuterium labeled DXd. DXd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) . | ||||||||||||||||||||
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DXd | 99.30% | DXd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). | ||||||||||||||||||||
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