MEDI4276 Antibody 

MEDI4276 Antibody is an HER2-targeted antibody, which can be used for the synthesis of the ADC molecule MEDI4276. MEDI4276 Antibody can be used in the study of cancer^[1].

scFv-Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

ERBB2/HER2/CD340

ADC antibodies act as the navigation system of ADC drugs and are primarily responsible for delivering payloads to target cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2064  [NCBI]

P04626

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

201.26 kDa

Liquid

Colorless to off-white

[MEDI4276 Antibody]

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  scFv-Human IgG1 kappa

• 
  Flow cytometric analysis of 1×10⁶ MCF-7 cells labeling HER2 (red) with MEDI4276 (HY-P991238). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.

• [1]. Li J, et al. MEDI4276, a HER2-targeting antibody tubulysin conjugate, displays potent in vitro and in vivo activity in preclinical studies[J]. Cancer Research, 2016, 76(14_Supplement): 2970-2970.