Gancotamab antibody
Based on 1 Customer Validation
Gancotamab antibody (MM-302) is a HER2-targeted antibody with antitumor activity.
For research use only. We do not sell to patients.
- Purity : ≥99.0%
- CAS No.: 1509928-00-0
- Molecular Weight:27.2 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Isotype
N-6*His-scFv-heavy-lambda
Species Reactivity
Human
IC50 & Target
[1]|
HER2 |
In Vitro
Gancotamab antibody (MM-302; 0.5 μM; 72 hours) increases cell death in BT474-M3 and NCI-N87 cells[1].
Gancotamab antibody (MM-302; 1 μM; 2-24 h) activates the p-p53 level and has no effect on p-Akt signal in BT474-M3 and NCI-N87 cells[1].
Gancotamab antibody (MM-302) is a HER2-targeted liposome encapsulating approximately 20,000 molecules of Doxorubicin in its core and 45 single-chain anti-HER2 antibodies (scFv) conjugated to its surface[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:BT474-M3 and NCI-N87 cells
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Concentration:0.5 μM
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Incubation Time:72 hours
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Result:Significantly reduced in vitro viability.
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Cell Line:BT474-M3 and NCI-N87 cells
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Concentration:1 μM
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Incubation Time:2 h, 8 h, and 24 h
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Result:Increased the p-p53 level and had no effect on p-Akt signal.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Seven-week-old female NCR/nu mice injected with NCI-N87 cells[1]
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Dosage:3 mg/kg
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Administration:i.v.; every 7 days; for 3 doses
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Result:Showed significantly antitumor activity.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Flow cytometric analysis of 1X106 AGS cells with Gancotamab (red). Cells stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 1509928-00-0
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Appearance Liquid
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Molecular Weight 27.2 kDa
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Color Colorless to light yellow
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SMILES
[Gancotamab antibody]
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Synonyms
MM-302 antibody
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gancotamab antibody Related Classifications
HY-P99630 Related Classifications
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