Gancotamab antibody
Based on 1 Customer Validation
Gancotamab antibody (MM-302) is a HER2-targeted antibody with antitumor activity.
For research use only. We do not sell to patients.
- Purity: ≥99.0%
- CAS No.: 1509928-00-0
- Molecular Weight:27.2 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
N-6*His-scFv-heavy-lambda
Human
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HER2 |
Gancotamab antibody (MM-302; 0.5 μM; 72 hours) increases cell death in BT474-M3 and NCI-N87 cells[1].
Gancotamab antibody (MM-302; 1 μM; 2-24 h) activates the p-p53 level and has no effect on p-Akt signal in BT474-M3 and NCI-N87 cells[1].
Gancotamab antibody (MM-302) is a HER2-targeted liposome encapsulating approximately 20,000 molecules of Doxorubicin in its core and 45 single-chain anti-HER2 antibodies (scFv) conjugated to its surface[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BT474-M3 and NCI-N87 cells
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Concentration:0.5 μM
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Incubation Time:72 hours
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Result:Significantly reduced in vitro viability.
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Cell Line:BT474-M3 and NCI-N87 cells
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Concentration:1 μM
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Incubation Time:2 h, 8 h, and 24 h
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Result:Increased the p-p53 level and had no effect on p-Akt signal.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Seven-week-old female NCR/nu mice injected with NCI-N87 cells[1]
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Dosage:3 mg/kg
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Administration:i.v.; every 7 days; for 3 doses
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Result:Showed significantly antitumor activity.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay
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Flow cytometric analysis of 1X106 AGS cells with Gancotamab (red). Cells stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 1509928-00-0
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Appearance Liquid
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Molecular Weight 27.2 kDa
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Color Colorless to light yellow
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SMILES
[Gancotamab antibody]
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Synonyms
MM-302 antibody
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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