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Results for "

HL-7702

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADAMTS (1) Apoptosis (10) Autophagy (1) Bacterial (2) Bcl-2 Family (3) Caspase (1) CDK (1) Cyclin G-associated Kinase (GAK) (1) DNA/RNA Synthesis (1) DYRK (1) Endogenous Metabolite (2) Endothelin Receptor (1) Environmental Pollutants (1) ERK (1) Fatty Acid Synthase (FASN) (2) Fungal (1) Glycosidase (2) GSK-3 (1) HBV (2) HDAC (1) HIV (1) MDM-2/p53 (1) MEK (1) NAMPT (1) P-glycoprotein (1) PARP (2) PERK (1) Phosphorylase (1) Raf (1) Ras (1) Reference Standards (2) SOS1 (1) Virus Protease (2)
By Research Areas:	Cancer (9) Infection (4) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (2)

By Targets:

ADAMTS (1)

Apoptosis (10)

Autophagy (1)

Bacterial (2)

Bcl-2 Family (3)

Caspase (1)

CDK (1)

Cyclin G-associated Kinase (GAK) (1)

DNA/RNA Synthesis (1)

DYRK (1)

Endogenous Metabolite (2)

Endothelin Receptor (1)

Environmental Pollutants (1)

ERK (1)

Fatty Acid Synthase (FASN) (2)

Fungal (1)

Glycosidase (2)

GSK-3 (1)

HBV (2)

HDAC (1)

HIV (1)

MDM-2/p53 (1)

MEK (1)

NAMPT (1)

P-glycoprotein (1)

PARP (2)

PERK (1)

Phosphorylase (1)

Raf (1)

Ras (1)

Reference Standards (2)

SOS1 (1)

Virus Protease (2)

By Research Areas:

Cancer (9)

Infection (4)

Inflammation/Immunology (4)

Metabolic Disease (3)

Neurological Disease (2)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0288

Lycorine 20+ Cited Publications	Fatty Acid Synthase (FASN) Virus Protease Bacterial Apoptosis	Inflammation/Immunology Cancer
Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a K_d value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription . Lycorine is also a melanoma vasculogenic inhibitor . Lycorine can be used for the study of prostate cancer and metabolic diseases .

HY-N0058

4,5-Dicaffeoylquinic acid 10+ Cited Publications IsocHLorogenic acid C	HBV Endogenous Metabolite Apoptosis Glycosidase	Infection
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .

HY-N7543

Schisantherin D	HIV Endothelin Receptor	Infection Metabolic Disease
Schisantherin D is a lignan. Schisantherin D can be isolated from Kadsura interior. Schisantherin D downregulates the expression of ETBR and inhibits the secretion of ECM and ET-1. Schisantherin D alleviates EtOH + ET-1-induced hepatocyte cytotoxicity. Schisantherin D potently inhibits HIV replication in cells .

HY-N0288R

Lycorine (Standard)	Fatty Acid Synthase (FASN) Virus Protease Bacterial Apoptosis Reference Standards	Inflammation/Immunology Cancer
Lycorine (Standard) is the analytical standard of Lycorine. This product is intended for research and analytical applications. Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription . Lycorine is also a melanoma vasculogenic inhibitor . Lycorine can be used for the study of prostate cancer and metabolic diseases .

HY-144826

ZDWX-25	GSK-3	Neurological Disease
ZDWX-25 is a highly potent GSK-3β and DYRK1A dual inhibitor with an IC₅₀ value of 71 nM for GSK-3β. ZDWX-25 possesses significant cytotoxic activities against SH-SY5Y and HL-7702 cells. ZDWX-25 can be used for researching alzheimer's disease .

HY-N0058R

4,5-Dicaffeoylquinic acid (Standard) IsocHLorogenic acid C (Standard)	Reference Standards HBV Endogenous Metabolite Apoptosis Glycosidase	Infection
4,5-Dicaffeoylquinic acid (Standard) is the analytical standard of 4,5-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .

HY-172394

ZSNI-21	HDAC ADAMTS Apoptosis Bcl-2 Family Cyclin G-associated Kinase (GAK)	Cancer
ZSNI-21 is a ADAM17/HDAC2 inhibitor with ADAM17 IC₅₀ 0.939 μM and HDAC2 IC₅₀ 0.844 μM. ZSNI-21 regulates the expression of apoptosis-related proteins (Bax, Bcl-2) and Cyclin D1, and induces apoptosis.. ZSNI-21 can be used for the research of hepatocellular carcinoma, breast cancer, and non-small cell lung cancer .

HY-162269

Nampt activator-5	NAMPT	Inflammation/Immunology
Nampt activator-5 is a NAMPT activator with a K_D value of 6.19 μM. Nampt activator-5 activates the rate-limiting enzyme in NAD ⁺ biosynthesis and promotes NAD ⁺ production. Nampt activator-5 delays the senescence process of senescent hepatocytes, extends the lifespan of Caenorhabditis elegans, and alleviates age-related dysfunction and abnormal biomarkers in naturally aged mice. Nampt activator-5 can be used in aging research .

HY-175560

SOS1-IN-22	SOS1 PERK	Cancer
SOS1-IN-22 is a son of sevenless homolog 1 (SOS1) inhibitor. SOS1-IN-22 can inhibit KRAS-G12C/SOS1 complex formation with an IC₅₀ value of 40.28 nM. SOS1-IN-22 can reduce phosphorylation ERK levels. SOS1-IN-22 can be used for the research of cancer, such as pancreatic carcinoma and appendiceal carcinoma .

HY-139140

BAY R3401	Phosphorylase	Metabolic Disease
BAY R3401 is an orally active glycogen phosphorylase inhibitor that can achieve irreversible and non-selective inhibition of hepatic glycogenolysis. BAY R3401 inhibits glycogenolysis in liver cells, with IC₅₀ values of 27.06 and 52.83 μM in HL-7702 and HepG2 cells, respectively. BAY R3401 can be used for the research of type 2 diabetes .

HY-N12711

Calycosin 7-O-xylosylglucoside	Others	Others
Calycosin 7-O-xylosylglucoside exhibits hepatoprotective efficacy in human hepatic cell HL-7702 through scavenging oxidative damage and antioxidant properties .

HY-169688

NA-17	MDM-2/p53 Apoptosis	Cancer
NA-17 is a naphthalimide compound with anti-tumor activity and lower toxicity to normal cells like HL-7702 and WI-38. NA-17 exhibits a p53-dependent selective inhibition in various NSCLC cells, inducing the accumulation of active p53 in the mitochondria and nuclei of NSCLC cells. NA-17 can cause cell cycle arrest in the G1 phase, leading to apoptosis and cell death .

HY-124451

2-Chloronaphthalene	Environmental Pollutants Apoptosis Autophagy	Cancer
2-Chloronaphthalene, serving as an intermediate in organic synthesis, is classified as a persistent organic pollutant. 2-Chloronaphthalene can induce apoptosis and autophagy, while inhibiting cell proliferation. 2-Chloronaphthalene leads to cell death through the interplay between autophagy and apoptosis .

HY-N17767

Leonoside F	Others	Inflammation/Immunology
Leonoside F is a phenylethanoid glycoside compound isolated from the aerial parts of Leonurus japonicus Houtt., which protects liver cells from chemically induced damage. At a concentration of 1×10 ^-5 M, Leonoside F shows significant hepatoprotective activity against D-galactosamine-induced damage in HL-7702 liver cells, with an inhibition rate of 30.9% .

HY-162597

Dyrk1A-IN-9	DYRK	Neurological Disease
Dyrk1A-IN-9 (Compound L9) is a moderately active DYRK1A inhibitor (IC₅₀: 1.67 μM). L9 shows neuroprotective activity by regulating the expression of Aβ and phosphorylation of Tau protein. Dyrk1A-IN-9 can be used for research of Alzheimer's disease .

HY-143302

Anticancer agent 31	Apoptosis	Cancer
Anticancer agent 31 is a 1,3-diphenylurea quinoxaline derivative, and a anticancer agent. Anticancer agent 31 exhibits antitumor acitvity by arresting cell cycle at S phase and inducing apoptosis .

HY-P10832

ATWLPPRAANLLMAAS	Apoptosis Ras Raf MEK ERK Caspase PARP Bcl-2 Family	Cancer
ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent anti-tumor effects. ATWLPPRAANLLMAAS can inhibit the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induce apoptosis. .

HY-N17630

Schekwangsienin	Others	Metabolic Disease
Schekwangsienin is a triterpenoid compound isolated from the aerial parts of Schefflera kwangsiensis. Schekwangsienin exhibits hepatoprotective activity and can be used in studies on liver injury .

HY-179614

PARP1-IN-50	PARP DNA/RNA Synthesis Apoptosis CDK Bcl-2 Family	Cancer
PARP1-IN-50 is a selective and orally active PARP-1 inhibitor with an IC₅₀ of 64.98 nM. PARP1-IN-50 can inhibit PAR formation and induce DNA double strand breaks, thereby causing DNA damage. PARP1-IN-50 can induce G2/M phase arrest and cancer cells apoptosis. PARP1-IN-50 demonstrates significant antiproliferative activity against various cancer cells. PARP1-IN-50 can be used for the research of cancer, such as breast cancer .

HY-181404

PA36-2	Fungal P-glycoprotein	Infection
PA36-2 is an Mdr1 inhibitor and azole resistance reversal agent, with a IC₅₀ of 1.0 μg/mL and a K_d of 4.209 μM against Candida albicans Mdr1. By effectively inhibiting the activity of the Mdr1 efflux pump, PA36-2 prevents the pumping of substrates out of cells, enhances the intracellular accumulation of azole antibiotics, and exerts a synergistic effect with antifungal agents such as Fluconazole (FLC) (HY-B0101). PA36-2 can be used in the research of azole-resistant candidiasis .

Cat. No.	Product Name	Target	Research Area

HY-P10832

ATWLPPRAANLLMAAS	Apoptosis Ras Raf MEK ERK Caspase PARP Bcl-2 Family	Cancer
ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent anti-tumor effects. ATWLPPRAANLLMAAS can inhibit the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induce apoptosis. .

Lycorine 20+ Cited Publications	Alkaloids other families Pyrrole Alkaloids Classification of Application Fields Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Amaryllidaceae Source Classification	Fatty Acid Synthase (FASN) Virus Protease Bacterial Apoptosis
Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a K_d value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription . Lycorine is also a melanoma vasculogenic inhibitor . Lycorine can be used for the study of prostate cancer and metabolic diseases .

4,5-Dicaffeoylquinic acid 10+ Cited Publications IsocHLorogenic acid C	Infection Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Bowdichia virgilioides Plants Compositae Endogenous metabolite Disease Research Fields Source Classification	HBV Endogenous Metabolite Apoptosis Glycosidase
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .

Schisantherin D	Schisandra sphenanthera Rehd. et Wils Infection Structural Classification Classification of Application Fields Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Source Classification	HIV Endothelin Receptor
Schisantherin D is a lignan. Schisantherin D can be isolated from Kadsura interior. Schisantherin D downregulates the expression of ETBR and inhibits the secretion of ECM and ET-1. Schisantherin D alleviates EtOH + ET-1-induced hepatocyte cytotoxicity. Schisantherin D potently inhibits HIV replication in cells .

Lycorine (Standard)	Alkaloids Structural Classification other families Pyrrole Alkaloids Plants Isoquinoline Alkaloids Amaryllidaceae Source Classification	Fatty Acid Synthase (FASN) Virus Protease Bacterial Apoptosis Reference Standards
Lycorine (Standard) is the analytical standard of Lycorine. This product is intended for research and analytical applications. Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription . Lycorine is also a melanoma vasculogenic inhibitor . Lycorine can be used for the study of prostate cancer and metabolic diseases .

4,5-Dicaffeoylquinic acid (Standard) IsocHLorogenic acid C (Standard)	Structural Classification Ketones, Aldehydes, Acids Phenols Polyphenols Bowdichia virgilioides Plants Compositae Endogenous metabolite Source Classification	Reference Standards HBV Endogenous Metabolite Apoptosis Glycosidase
4,5-Dicaffeoylquinic acid (Standard) is the analytical standard of 4,5-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .

Calycosin 7-O-xylosylglucoside	Flavonoids Flavones Leguminosae Sophora flavescens Aiton Plants Source Classification	Others
Calycosin 7-O-xylosylglucoside exhibits hepatoprotective efficacy in human hepatic cell HL-7702 through scavenging oxidative damage and antioxidant properties .

Leonoside F	Structural Classification Erythrophleum fordii Oliv. Monophenols Labiatae Phenols Plants Source Classification	Others
Leonoside F is a phenylethanoid glycoside compound isolated from the aerial parts of Leonurus japonicus Houtt., which protects liver cells from chemically induced damage. At a concentration of 1×10 ^-5 M, Leonoside F shows significant hepatoprotective activity against D-galactosamine-induced damage in HL-7702 liver cells, with an inhibition rate of 30.9% .

Schekwangsienin	Triterpenes Structural Classification Terpenoids Heptapleurum leucanthum (R. Vig.) Y. F. Deng Plants Araliaceae Source Classification	Others
Schekwangsienin is a triterpenoid compound isolated from the aerial parts of Schefflera kwangsiensis. Schekwangsienin exhibits hepatoprotective activity and can be used in studies on liver injury .

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