ATWLPPRAANLLMAAS
ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent anti-tumor effects. ATWLPPRAANLLMAAS can inhibit the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induce apoptosis..
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1228447-26-4
- Formel: C76H123N21O20S
- Molecular Weight:1682.98
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle MEK Isoform-spezifische Produkte anzeigen
MoreAlle Caspase Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
In Vitro
ATWLPPRAANLLMAAS (V3) (25-200 μM; 12-24 h) can inhibit the proliferation, viability, migration and invasion of human HCC (SMMC-7721, Huh-7) cells by inhibiting the Ras/Raf/MEK/ERK signaling pathway, however, no significant effect was observed in HL-7702 cells[2]. ATWLPPRAANLLMAAS (200 µM; 24 h) increases apoptosis and decreases protein levels of H-RAS, phosphorylated (p)-RAF, p-MEK, and p-extracellular signal-regulated protein kinase (ERK) in human HCC (SMMC-7721, Huh-7) cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HL-7702, SMMC-7721, Huh-7
-
Concentration:25, 50, 100, 200 µM
-
Incubation Time:12h, 24 h
-
Result:Inhibited the migration of SMMC-7721 and Huh-7 cells in a dose-dependent manner, but had no effect on HL-7702 cells.
-
Cell Line:SMMC-7721, Huh-7
-
Concentration:200 μM
-
Incubation Time:24 h
-
Result:Remarkably increased the apoptotic index, protein expressions of cleaved caspase-3, 8, 9, cleaved PARP, as well as Bax/Bcl-2 and Bad/Bcl-xl ratios.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 1228447-26-4
-
Molecular Weight 1682.98
-
Formel C76H123N21O20S
-
Sequence
Ala-Thr-Trp-Leu-Pro-Pro-Arg-Ala-Ala-Asn-Leu-Leu-Met-Ala-Ala-Ser
-
Sequence Shortening
ATWLPPRAANLLMAAS
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ATWLPPRAANLLMAAS Related Classifications
HY-P10832 Related Classifications
Powered by Bioz