ATWLPPRAANLLMAAS
ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent anti-tumor effects. ATWLPPRAANLLMAAS can inhibit the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induce apoptosis..
For research use only. We do not sell to patients.
- CAS No.: 1228447-26-4
- Formula: C76H123N21O20S
- Molecular Weight:1682.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
ATWLPPRAANLLMAAS (V3) (25-200 μM; 12-24 h) can inhibit the proliferation, viability, migration and invasion of human HCC (SMMC-7721, Huh-7) cells by inhibiting the Ras/Raf/MEK/ERK signaling pathway, however, no significant effect was observed in HL-7702 cells[2]. ATWLPPRAANLLMAAS (200 µM; 24 h) increases apoptosis and decreases protein levels of H-RAS, phosphorylated (p)-RAF, p-MEK, and p-extracellular signal-regulated protein kinase (ERK) in human HCC (SMMC-7721, Huh-7) cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL-7702, SMMC-7721, Huh-7
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Concentration:25, 50, 100, 200 µM
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Incubation Time:12h, 24 h
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Result:Inhibited the migration of SMMC-7721 and Huh-7 cells in a dose-dependent manner, but had no effect on HL-7702 cells.
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Cell Line:SMMC-7721, Huh-7
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Concentration:200 μM
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Incubation Time:24 h
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Result:Remarkably increased the apoptotic index, protein expressions of cleaved caspase-3, 8, 9, cleaved PARP, as well as Bax/Bcl-2 and Bad/Bcl-xl ratios.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1228447-26-4
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Molecular Weight 1682.98
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Formula C76H123N21O20S
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Sequence
Ala-Thr-Trp-Leu-Pro-Pro-Arg-Ala-Ala-Asn-Leu-Leu-Met-Ala-Ala-Ser
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Sequence Shortening
ATWLPPRAANLLMAAS
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ATWLPPRAANLLMAAS Related Classifications
HY-P10832 Related Classifications
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