PARP1-IN-50 

PARP1-IN-50 is a selective and orally active PARP-1 inhibitor with an IC₅₀ of 64.98 nM. PARP1-IN-50 can inhibit PAR formation and induce DNA double strand breaks, thereby causing DNA damage. PARP1-IN-50 can induce G2/M phase arrest and cancer cells apoptosis. PARP1-IN-50 demonstrates significant antiproliferative activity against various cancer cells. PARP1-IN-50 can be used for the research of cancer, such as breast cancer^[1].

PARP1-IN-50 (Compound 13) demonstrates significant antiproliferative activity in HCC-1937, Capan-1, MCF-7 and PANC-1 cells with an IC₅₀ of 0.88, 0.56, 4.49 and 1.53 μM^[1].
PARP1-IN-50 (1-10 μM, 48 h) induces G2/M arrest and inhibits the expression levels of CDK1 and cyclin B in HCC-1937 cells^[1].
PARP1-IN-50 (1-10 μM, 4 h) inhibits H₂O₂-induced PAR formation in HCC-1937 cells^[1].
PARP1-IN-50 (1-10 μM, 30 mins) increases PARP-1-DNA trapping and induces DNA double strand breaks in HCC-1937 cells^[1].
PARP1-IN-50 (1-10 μM, 48 h) induces apoptosis in HCC-1937 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PARP1-IN-50 (Compound 13) (25-50 mg/kg, p.o., daily for 21 days) significantly inhibits HCC-1937 xenograft tumor growth with a favorable safety profile in BALB/c nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

662.42

C₂₂H₂₆Br₂N₆O₄S₂

2255341-36-5

NC(N/N=C/C1=CC(Br)=C(OCCCCOC2=C(C=C(C=C2Br)/C=N/NC(N)=S)OC)C(OC)=C1)=S

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang L, et al. Discovery of novel thiosemicarbazone dimers as effective inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) for use in cancer therapy. Eur J Med Chem. 2026;302(Pt 1):118312.  [Content Brief]