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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

HL-7702 cell

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

4

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N7543
    Schisantherin D

    		HIV Endothelin Receptor Infection Metabolic Disease
    Schisantherin D is a lignan. Schisantherin D can be isolated from Kadsura interior. Schisantherin D downregulates the expression of ETBR and inhibits the secretion of ECM and ET-1. Schisantherin D alleviates EtOH + ET-1-induced hepatocyte cytotoxicity. Schisantherin D potently inhibits HIV replication in cells .
    Schisantherin D
  • HY-144826
    ZDWX-25

    		GSK-3 Neurological Disease
    ZDWX-25 is a highly potent GSK-3β and DYRK1A dual inhibitor with an IC50 value of 71 nM for GSK-3β. ZDWX-25 possesses significant cytotoxic activities against SH-SY5Y and HL-7702 cells. ZDWX-25 can be used for researching alzheimer's disease .
    ZDWX-25
  • HY-162269
    Nampt activator-5

    		NAMPT Inflammation/Immunology
    Nampt activator-5 is a NAMPT activator with a KD value of 6.19 μM. Nampt activator-5 activates the rate-limiting enzyme in NAD + biosynthesis and promotes NAD + production. Nampt activator-5 delays the senescence process of senescent hepatocytes, extends the lifespan of *Caenorhabditis elegans*, and alleviates age-related dysfunction and abnormal biomarkers in naturally aged mice. Nampt activator-5 can be used in aging research .
    Nampt activator-5
  • HY-139140
    BAY R3401

    		Phosphorylase Metabolic Disease
    BAY R3401 is an orally active glycogen phosphorylase inhibitor that can achieve irreversible and non-selective inhibition of hepatic glycogenolysis. BAY R3401 inhibits glycogenolysis in liver cells, with IC50 values of 27.06 and 52.83 μM in HL-7702 and HepG2 cells, respectively. BAY R3401 can be used for the research of type 2 diabetes .
    BAY R3401
  • HY-N12711
    Calycosin 7-O-xylosylglucoside

    		Others Others
    Calycosin 7-O-xylosylglucoside exhibits hepatoprotective efficacy in human hepatic cell HL-7702 through scavenging oxidative damage and antioxidant properties .
    Calycosin 7-O-xylosylglucoside
  • HY-169688
    NA-17

    		MDM-2/p53 Apoptosis Cancer
    NA-17 is a naphthalimide compound with anti-tumor activity and lower toxicity to normal cells like HL-7702 and WI-38. NA-17 exhibits a p53-dependent selective inhibition in various NSCLC cells, inducing the accumulation of active p53 in the mitochondria and nuclei of NSCLC cells. NA-17 can cause cell cycle arrest in the G1 phase, leading to apoptosis and cell death .
    NA-17
  • HY-N17767
    Leonoside F

    		Others Inflammation/Immunology
    Leonoside F is a phenylethanoid glycoside compound isolated from the aerial parts of Leonurus japonicus Houtt., which protects liver cells from chemically induced damage. At a concentration of 1×10 -5 M, Leonoside F shows significant hepatoprotective activity against D-galactosamine-induced damage in HL-7702 liver cells, with an inhibition rate of 30.9% .
    Leonoside F
  • HY-162597
    Dyrk1A-IN-9

    		DYRK Neurological Disease
    Dyrk1A-IN-9 (Compound L9) is a moderately active DYRK1A inhibitor (IC50: 1.67 μM). L9 shows neuroprotective activity by regulating the expression of Aβ and phosphorylation of Tau protein. Dyrk1A-IN-9 can be used for research of Alzheimer's disease .
    Dyrk1A-IN-9
  • HY-143302
    Anticancer agent 31

    		Apoptosis Cancer
    Anticancer agent 31 is a 1,3-diphenylurea quinoxaline derivative, and a anticancer agent. Anticancer agent 31 exhibits antitumor acitvity by arresting cell cycle at S phase and inducing apoptosis .
    Anticancer agent 31
  • HY-N17630
    Schekwangsienin

    		Others Metabolic Disease
    Schekwangsienin is a triterpenoid compound isolated from the aerial parts of Schefflera kwangsiensis. Schekwangsienin exhibits hepatoprotective activity and can be used in studies on liver injury .
    Schekwangsienin
  • HY-181404
    PA36-2

    		Fungal P-glycoprotein Infection
    PA36-2 is an Mdr1 inhibitor and azole resistance reversal agent, with a IC50 of 1.0 μg/mL and a Kd of 4.209 μM against Candida albicans Mdr1. By effectively inhibiting the activity of the Mdr1 efflux pump, PA36-2 prevents the pumping of substrates out of cells, enhances the intracellular accumulation of azole antibiotics, and exerts a synergistic effect with antifungal agents such as Fluconazole (FLC) (HY-B0101). PA36-2 can be used in the research of azole-resistant candidiasis .
    PA36-2

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