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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

IL-33 Antibody

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (8) MDM-2/p53 (1) NF-κB (2)
By Research Areas:	Cardiovascular Disease (1) Inflammation/Immunology (8)

Inhibitors & Agonists

Inhibitory Antibodies

Antibodies

Targets Recommended: ADC Antibody Interleukin Related IRAK Antibody-Drug Conjugates (ADCs) Antibody-Oligonucleotide Conjugates (AOCs) ADC Linker Itk PROTAC-Linker Conjugates for PAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99444

Astegolimab 2 Publications Verification MSTT 1041A; RG 6149	Interleukin Related MDM-2/p53 NF-κB	Cardiovascular Disease Inflammation/Immunology
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research .

HY-P99673

Itepekimab 1 Publications Verification REGN-3500; SAR-440340	Interleukin Related NF-κB	Inflammation/Immunology
Itepekimab (REGN-3500) is an IgG4 monoclonal antibody against *IL-33*. Itepekimab reduced airway inflammation and related tissue damage in preliminary clinical studies. Itepekimab has potential effects in asthma, chronic obstructive pulmonary disease (COPD), and atopic dermatitis (AD) .

HY-P991267

CAN10	Interleukin Related	Inflammation/Immunology
CAN10 is is a humanized monoclonal antibody inhibitor targeting interleukin 1RAP (IL1RAP). CAN10 blocks IL-1, *IL-33, and IL-36* signalling by targeting IL1RAP, preventing downstream proinflammatory and profibrotic responses. CAN10 reduces dermal and pulmonary fibrosis. CAN10 can be used for the research of immune system diseases, such as systemic sclerosis .

HY-P99018

Etokimab Antibody ANB 020	Interleukin Related	Inflammation/Immunology
Etokimab (Antibody ANB 020) is a humanized monoclonal antibody that targets IL-33. Etokimab can be used for the research of atopic dermatitis .

HY-P990669

Torudokimab	Interleukin Related	Inflammation/Immunology
Torudokimab is a humanized antibody expressed in CHO, targeting *IL-33*. Torudokimab has a huIgG4SP type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 145.22 kDa. The isotype control for Torudokimab can refer to Human IgG4 kappa, Isotype Control (HY-P99003).

HY-P99729

Melrilimab GSK 3772847; CNTO-7160	Interleukin Related	Inflammation/Immunology
Melrilimab (GSK 3772847) is an IgG2-kappa *anti-IL1RL1/ST2/IL33R/DER4/FIT-1* monoclonal antibody. Melrilimab can be used for the research of asthma .

HY-P991633

TQC2938	Interleukin Related	Inflammation/Immunology
TQC2938 is a humanized IgG2 monoclonal antibody inhibitor targeting Stimulation-2 (ST2). TQC2938 inhibits the ST2/IL-33 signaling pathway, reduces the level of downstream Th2 cytokines (such as IL-4, IL-5, and IL-13) and eosinophils as well as other inflammatory cells. TQC2938 can be used for inflammatory diseases like asthma research .

HY-P992440

PF-06817024	Interleukin Related	Inflammation/Immunology
PF-06817024 is a high affinity, humanized antibody that binds IL-33. PF-06817024 binds to *IL-33, prevents IL-33* from binding to receptor ST2, and inhibits downstream type 2 inflammatory responses. PF-06817024 can be used for the research of allergic diseases .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99444

Astegolimab 2 Publications Verification MSTT 1041A; RG 6149	Interleukin Related MDM-2/p53 NF-κB	Cardiovascular Disease Inflammation/Immunology
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research .

HY-P99673

Itepekimab 1 Publications Verification REGN-3500; SAR-440340	Interleukin Related NF-κB	Inflammation/Immunology
Itepekimab (REGN-3500) is an IgG4 monoclonal antibody against *IL-33*. Itepekimab reduced airway inflammation and related tissue damage in preliminary clinical studies. Itepekimab has potential effects in asthma, chronic obstructive pulmonary disease (COPD), and atopic dermatitis (AD) .

HY-P991267

CAN10	Interleukin Related	Inflammation/Immunology
CAN10 is is a humanized monoclonal antibody inhibitor targeting interleukin 1RAP (IL1RAP). CAN10 blocks IL-1, *IL-33, and IL-36* signalling by targeting IL1RAP, preventing downstream proinflammatory and profibrotic responses. CAN10 reduces dermal and pulmonary fibrosis. CAN10 can be used for the research of immune system diseases, such as systemic sclerosis .

HY-P99018

Etokimab Antibody ANB 020	Interleukin Related	Inflammation/Immunology
Etokimab (Antibody ANB 020) is a humanized monoclonal antibody that targets IL-33. Etokimab can be used for the research of atopic dermatitis .

HY-P990669

Torudokimab	Interleukin Related	Inflammation/Immunology
Torudokimab is a humanized antibody expressed in CHO, targeting *IL-33*. Torudokimab has a huIgG4SP type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 145.22 kDa. The isotype control for Torudokimab can refer to Human IgG4 kappa, Isotype Control (HY-P99003).

HY-P99729

Melrilimab GSK 3772847; CNTO-7160	Interleukin Related	Inflammation/Immunology
Melrilimab (GSK 3772847) is an IgG2-kappa *anti-IL1RL1/ST2/IL33R/DER4/FIT-1* monoclonal antibody. Melrilimab can be used for the research of asthma .

HY-P991633

TQC2938	Interleukin Related	Inflammation/Immunology
TQC2938 is a humanized IgG2 monoclonal antibody inhibitor targeting Stimulation-2 (ST2). TQC2938 inhibits the ST2/IL-33 signaling pathway, reduces the level of downstream Th2 cytokines (such as IL-4, IL-5, and IL-13) and eosinophils as well as other inflammatory cells. TQC2938 can be used for inflammatory diseases like asthma research .

HY-P992440

PF-06817024	Interleukin Related	Inflammation/Immunology
PF-06817024 is a high affinity, humanized antibody that binds IL-33. PF-06817024 binds to *IL-33, prevents IL-33* from binding to receptor ST2, and inhibits downstream type 2 inflammatory responses. PF-06817024 can be used for the research of allergic diseases .

Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (1) Rat (1) Mouse (1) human (1)
Application:	IHC-P (1) ICC/IF (2) IP (1) WB (3) FC (1) ELISA (1)
Isotype:	IgG (1) IgG1 (1) IgG2b (1)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P89813

	IL-33 Antibody (YA9157)	WB, IP, ELISA	human
	IL-33 Antibody (YA9157) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to IL-33.

HY-P810730

	IL-33 Antibody (YA9974) C9orf26; IL1F11; NFHEV; Interleukin-33; IL-33; Interleukin-1 famILy member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV	WB, IHC-P, ICC/IF	Mouse, Rat
	IL-33 Antibody (YA9974) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to IL-33 Antibody.

HY-P87275

	ST2 Antibody (YA6958) DER-4 Antibody; DER4 Antibody; FIT 1 Antibody; Growth stimulation expressed Antibody; homolog of mouse growth stimulation-expressed Antibody; IL1rl1 Antibody; IL33R Antibody; ILRL1_HUMAN Antibody; Interleukin 1 receptor like 1 Antibody; interleukin 1 receptor related protein Antibody	WB, ICC/IF, FC	Human
	ST2 Antibody (YA6958) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ST2.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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