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ST2 Antibody (YA6958)

(Synonyms: DER-4 antibody; DER4 antibody; FIT 1 antibody; Growth stimulation expressed antibody; homolog of mouse growth stimulation-expressed antibody; Il1rl1 antibody; IL33R antibody; ILRL1_HUMAN antibody; Interleukin 1 receptor like 1 antibody; interleukin 1 receptor related protein antibody)
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Based on 1 Customer Validation

ST2 Antibody (YA6958) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ST2.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, ICC/IF, FC

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for ST2 Antibody (YA6958)
  • ST2 Antibody (YA6958) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:1000 1:100 1:1000

Product Details

Description

ST2 Antibody (YA6958) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ST2.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 80 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 63.4 kDa
Immunogen

Recombinant protein within human ST2 aa 19-328 (Extracellular).

Sensitivity

Endogenous

Purification

Protein A affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

RRID

AB_3719303

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for ST2 Antibody (YA6958)
    Western blot analysis of extracts from Human kidney (lane 1(40μg)) 、Human lung (lane 2(40μg)) and Human lung cancer (lane 3(40μg)) using ST2 Antibody (HY-P87275) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (β Tubulin, 1/5000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.

Background

  • Function

    ST2 receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages|Inhibits IL-33 signaling[1][2].

  • Subcellular Localization

    Cell membrane,Secreted,Cell membrane

  • Expression


    Tissue_Specificity: Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver

  • Isoforms & Post-Translational Modification

    Q01638 has four isomers: Q01638-1: 63358 Da (predicted); Q01638-2: 36993 Da (predicted); Q01638-3: 29951 Da (predicted); Q01638-4: 23723 Da (predicted).
    Ubiquitinated at Lys-321 in a FBXL19-mediated manner; leading to proteasomal degradation

  • Subunit

    Interacts with MYD88, IRAK1, IRAK4, and TRAF6

  • SwissProt ID

    Q01638

  • Synonyms

    DER-4 antibody; DER4 antibody; FIT 1 antibody; Growth stimulation expressed antibody; homolog of mouse growth stimulation-expressed antibody; Il1rl1 antibody; IL33R antibody; ILRL1_HUMAN antibody; Interleukin 1 receptor like 1 antibody; interleukin 1 receptor related protein antibody

ST2 Antibody (YA6958) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Western blot analysis of extracts from Human kidney (lane 1(40μg)) 、Human lung (lane 2(40μg)) and Human lung cancer (lane 3(40μg)) using ST2 Antibody (HY-P87275) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (β Tubulin, 1/5000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.

  • ST2 Antibody (YA6958) Product Image
    1/16
  • Experimental Validation Results for ST2 Antibody (YA6958)
  • ST2 Antibody (YA6958) Product Image
  • Experimental Validation Results for ST2 Antibody (YA6958)
    1/1
    MedChemExpress Validation
     Western blot analysis of extracts from Human kidney (lane 1(40μg)) 、Human lung (lane 2(40μg)) and Human lung cancer (lane 3(40μg)) using ST2 Antibody (HY-P87275) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (β Tubulin, 1/5000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.
  • Experimental Validation Results for ST2 Antibody (YA6958)
  • ST2 Antibody (YA6958) Product Image
    MedChemExpress Validation

    Western blot analysis of extracts from Human kidney (lane 1(40μg)) 、Human lung (lane 2(40μg)) and Human lung cancer (lane 3(40μg)) using ST2 Antibody (HY-P87275) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (β Tubulin, 1/5000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.

  • ST2 Antibody (YA6958) Product Image WB