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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
MDH-2
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "MDH-2" in MCE Product Catalog:
66
66 Publications Verification
Synonyms: HIF-1α inhibitor; LW8
Target:
Research Areas:
LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor with an IC50 value of 4.4 μM, and it is also an inhibitor of MDH2. LW6 decreases HIF-1α protein expression without affecting HIF-1β expression.
9
9 Cited Publications
Research Areas:
GNE-140 racemate is a racemic mixture of (R)-GNE-140 (HY-100742A) and (S)-GNE-140 (HY-100742B), and also a tautomer of GNE-140 (HY-118241). GNE-140 racemate is an orally active lactate dehydrogenase inhibitor, with an IC50 of 3 nM against human LDHA and an IC50 of 5 nM against LDHB. GNE-140 racemate reduces the phosphorylation level and total protein expression of p38 MAPK, and inhibits EGF-induced AKT phosphorylation. GNE-140 racemate decreases lactate production, regulates glycolysis, the pentose phosphate pathway and nucleotide biosynthesis, increases extracellular pH, inhibits cell proliferation, migration and invasion, and induces caspase-3 activation and ROS accumulation. GNE-140 racemate can be used in research related to breast cancer, cystic fibrosis and pancreatic cancer [2] .
1
1 Cited Publications
Research Areas:
MDH1-IN-2 (Compound 7c) is a selective MDH1 inhibitor, with IC50 values of 2.27 and 27.47 μM for MDH1 and MDH2, respectively. MDH1-IN-2 can reduce the generation of ROS by inhibiting the conversion of 2-Ketoglutaric acid (HY-W013636) to α-Hydroxyglutaric acid (HY-113038B) mediated by MDH1, thereby suppressing 2-Ketoglutaric acid (HY-W013636)-induced ferroptosis [2].
Cat. No.: HY-RS16896
Target:
Research Areas:
Mdh2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mdh2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS08261
Target:
Research Areas:
MDH2 Human Pre-designed siRNA Set A contains three designed siRNAs for MDH2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23338
Target:
Research Areas:
Mdh2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mdh2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-181604
CAS No.: 3047410-41-0
Target:
Research Areas:
MDH2-IN-2 is an orally active MDH2 inhibitor with an IC50 of 5.9 μM. MDH2-IN-2 reduces the levels of senescence markers and senescence-associated secretory phenotype (SASP) factors in mammalian cell models. MDH2-IN-2 extends the lifespan and improves the healthspan of Caenorhabditis elegans. MDH2-IN-2 alleviates tissue senescence in aged mice, inhibits SASP factors, and restores liver and kidney functions. MDH2-IN-2 is applicable for senescence-related research .
Cat. No.: HY-P70350
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MDH2; MGC:3559; Malate Dehydrogenase 2; EIEE51; Malate Dehydrogenase 2, NAD (Mitochondrial); DEE51; Malate Dehydrogenase, Mitochondrial; M-MDH; Testicular Tissue Protein Li 120; MOR1; Uncharacterized Protein MDH2; MDH; Malate Dehydrogenase
Species:
Human
Source:
HEK293
Cat. No.: HY-P703514
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MDH2; MGC:3559; Malate Dehydrogenase 2; EIEE51; Malate Dehydrogenase 2, NAD (Mitochondrial); DEE51; Malate Dehydrogenase, Mitochondrial; M-MDH; Testicular Tissue Protein Li 120; MOR1; Uncharacterized Protein MDH2; MDH; Malate Dehydrogenase
Species:
Human
Source:
E. coli
Cat. No.: HY-100742R
CAS No.: 1802977-61-2
GNE-140 racemate (Standard) is the analytical standard of GNE-140 racemate (HY-100742). This product is intended for research and analytical applications. GNE-140 racemate is a racemic mixture of (R)-GNE-140 (HY-100742A) and (S)-GNE-140 (HY-100742B), and also a tautomer of GNE-140 (HY-118241). GNE-140 racemate is an orally active lactate dehydrogenase inhibitor, with an IC50 of 3 nM against human LDHA and an IC50 of 5 nM against LDHB. GNE-140 racemate reduces the phosphorylation level and total protein expression of p38 MAPK, and inhibits EGF-induced AKT phosphorylation. GNE-140 racemate decreases lactate production, regulates glycolysis, the pentose phosphate pathway and nucleotide biosynthesis, increases extracellular pH, inhibits cell proliferation, migration and invasion, and induces caspase-3 activation and ROS accumulation. GNE-140 racemate can be used in research related to breast cancer, cystic fibrosis and pancreatic cancer [2] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
