9 Results for "

MMP-1 inhibition

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "MMP-1 inhibition" in MCE Product Catalog:

  • Targets Recommended:
2
(+)-Columbianetin
(+)-Columbianetin
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2 Cited Publications
Cat. No.: HY-N0363
CAS No.: 3804-70-4
Synonyms: (S)-Columbianetin
Category:  

Coumarins Phenylpropanoids Plants Umbelliferae Seriphidium transiliense Disease Research Fields Inflammation/Immunology

Target:  

ERK JNK Collagen TGF-beta/Smad p38 MAPK Reactive Oxygen Species (ROS)

(+)-Columbianetin ((S)-Columbianetin) acts as an inhibitor of JNK/ERK. (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin is applicable to research related to skin aging .
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2
(+)-Columbianetin acetate
(+)-Columbianetin acetate
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2 Cited Publications
Cat. No.: HY-N0363A
CAS No.: 23180-65-6
Synonyms: (S)-Columbianetin acetate
Category:  

other families Coumarins Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Fungal

(+)-Columbianetin ((S)-Columbianetin) acetate acts as an inhibitor of JNK/ERK. (+)-Columbianetin acetate inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin acetate regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin acetate is applicable to research related to skin aging .
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Licoricidin
Licoricidin
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Cat. No.: HY-N3387
CAS No.: 30508-27-1
Category:  

Flavonoids Leguminosae Flavanols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology

Target:  

Apoptosis NF-κB Akt MMP

Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC50=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer . Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect . Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo . Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations .
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MMP-2 Inhibitor II
MMP-2 Inhibitor II
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Cat. No.: HY-130076
CAS No.: 869577-51-5
Target:  

MMP

Research Areas:  

Cancer

MMP-2 Inhibitor II (compound 2) is a selective MMP-2 inhibitor. The Kinetic parameters for MMP inhibition are 2.4 μM (MMP-2), 45 μM (MMP-1), and 379 μM (MMP-7), respectively .
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Exserohilone
Exserohilone
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Cat. No.: HY-N12653
CAS No.: 99572-22-2
Synonyms: (-)-Exserohilone
Category:  

Microorganisms Antibiotics Other Antibiotics

Target:  

Reactive Oxygen Species (ROS)

Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced ROS generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts .
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(+)-Columbianetin acetate (Standard)
(+)-Columbianetin acetate (Standard)
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Cat. No.: HY-N0363AR
CAS No.: 23180-65-6
Synonyms: (S)-Columbianetin acetate (Standard)
Category:  

other families Coumarins Phenylpropanoids Plants

Target:  

Reference Standards Fungal

(+)-Columbianetin acetate (Standard) is the analytical standard of (+)-Columbianetin acetate (HY-N0363A). This product is intended for research and analytical applications. (+)-Columbianetin acetate ((S)-Columbianetin) acts as an inhibitor of JNK/ERK. (+)-Columbianetin acetate inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin acetate regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin acetate is applicable to research related to skin aging .
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(+)-Columbianetin (Standard)
(+)-Columbianetin (Standard)
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Cat. No.: HY-N0363R
CAS No.: 3804-70-4
Synonyms: (S)-Columbianetin (Standard)
Category:  

Coumarins Phenylpropanoids Plants Umbelliferae Seriphidium transiliense

Target:  

Reference Standards Collagen p38 MAPK ERK TGF-beta/Smad JNK Reactive Oxygen Species (ROS)

(+)-Columbianetin (Standard) is the analytical standard of (+)-Columbianetin (HY-N0363). This product is intended for research and analytical applications. (+)-Columbianetin ((S)-Columbianetin) acts as an inhibitor of JNK/ERK. (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin is applicable to research related to skin aging .
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Dipeptide 2 (Standard)
Dipeptide 2 (Standard)
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Cat. No.: HY-118060R
CAS No.: 24587-37-9
Synonyms: N-Valyltryptophan (Standard); Val-Trp (Standard)
Target:  

Angiotensin-converting Enzyme (ACE) Reference Standards

Research Areas:  

Cardiovascular Disease

Dipeptide 2 (Standard) is the analytical standard of Dipeptide 2. This product is intended for research and analytical applications. Dipeptide 2 (N-Valyltryptophan; Val-Trp) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient . Dipeptide 2 is an angiotensin-converting Enzyme (ACE) .
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PAI-1-IN-1
PAI-1-IN-1
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Cat. No.: HY-183626
CAS No.: 1247823-40-0
Target:  

PAI-1 Ser/Thr Protease Furin MMP Notch Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

PAI-1-IN-1 is an orally active and specific PAI-1 inhibitor with an IC50 of <6.95 μM. PAI-1-IN-1 blocks the interaction between PAI-1 and serine proteases or LRP-1, and enhances plasmin generation. PAI-1-IN-1 restores macrophage efferocytosis and promotes macrophage polarization. PAI-1-IN-1 alleviates PAI-1-mediated inhibition of Furin, promotes MT1-MMP maturation, activates the NOTCH1 signaling pathway, inhibits proliferation and induces apoptosis. PAI-1-IN-1 promotes skeletal muscle regeneration and alleviates inflammation in a mouse model of skeletal muscle injury. PAI-1-IN-1 can be used in research on skeletal muscle injury-induced inflammation and chronic myeloid leukemia .
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