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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
Mycobacterium species
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "Mycobacterium species" in MCE Product Catalog:
Cat. No.: HY-N14690
CAS No.: 83858-82-6
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Cat. No.: HY-121071
CAS No.: 91432-48-3
Cat. No.: HY-131597
CAS No.: 21238-36-8
Synonyms: 8-Hydroxyguanosine triphosphate
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8-Oxo-GTP (8-Hydroxyguanosine triphosphate) is an oxidized guanine nucleotide, produced by reactive oxygen species (ROS). 8-Oxo-GTP serves as a substrate for MutT protein, GTP cyclohydrolase II, Mycobacterium tuberculosis MutT1, and Mycobacterium tuberculosis Rv1700, which hydrolyze it to corresponding nucleoside monophosphates or diphosphates. 8-Oxo-GTP causes detrimental effects including mutations and mistranslation when incorporated into nucleic acids. 8-Oxo-GTP can be used for the research of cancer and tuberculosis .
Cat. No.: HY-N3700
CAS No.: 54354-62-0
Synonyms: Rutaceline
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Cat. No.: HY-N9947
CAS No.: 23513-10-2
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Cat. No.: HY-N9947A
CAS No.: 61914-52-1
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Cat. No.: HY-159899
CAS No.: 2941327-87-1
DHFR-IN-22 (Compound 8) is a DHFR (Dihydrofolate Reductase) inhibitor belonging to the class of 2,4-diaminopyrimidine compounds. DHFR-IN-22 exhibits significant inhibitory activity against purified DHFR enzyme and major species of nontuberculous mycobacteria (NTM), namely Mycobacterium avium and Mycobacterium abscessus. It shows an IC50 of 1.1 nM and MIC of 1.5 μg/mL against M. abscessus, and an IC50 of 6.3 nM and MIC of 0.1 μg/mL against M. avium. Additionally, it demonstrates an IC50 of 2100 nM against human DHFR. DHFR-IN-22 holds potential for studying novel strategies to combat NTM infections .
Cat. No.: HY-189256
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20S Proteasome-IN-6 is a species-selective inhibitor of the Mycobacterium tuberculosis 20S proteasome. 20S Proteasome-IN-6 penetrates the Mycobacterium tuberculosis bacilli, sensitizes the bacteria to nitrosative stress, and reduces the bacterial burden of live Mycobacterium tuberculosis within infected macrophages. 20S Proteasome-IN-6 can be used for tuberculosis research .
Cat. No.: HY-187375
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DL25 is a fungicide with an IC50 of 5.0 μg/mL against Mycobacterium tuberculosis DHQS. DL25 binds with high affinity to mycobacterial targets LysA, LpdA and SecA1. DL25 exhibits broad-spectrum anti-mycobacterial activity against multiple mycobacterial species and shows partial synergy with established anti-tuberculosis drugs. DL25 can be used in studies related to tuberculosis .
Cat. No.: HY-184408
CAS No.: 3033990-94-9
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AAP-SO2 is a Bactericide and Mycobacterium tuberculosis RNA polymerase (Mtb RNAP) inhibitor, with an IC50 of 0.025 μM against Mtb RNAP. AAP-SO2 allosterically slows the nucleotide addition rate during transcriptional elongation and enhances transcription termination efficiency. AAP-SO2 exhibits increased activity against β S450L-type Mtb, possesses activity against non-replicating Mtb, and shows whole-cell activity against Mtb and related mycobacterial species. AAP-SO2 reduces the overall emergence rate of Rifampicin (HY-B0272) tolerance in Mtb, alters the mutation spectrum, and decreases the proportion of β S450L-type Rifampicin-resistant mutants. AAP-SO2 acts synergistically with Rifampicin to kill non-replicating Mtb in a rabbit caseous necrosis model. AAP-SO2 can be used for the research of tuberculosis .
Cat. No.: HY-N19212
CAS No.: 3040055-59-9
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Cat. No.: HY-N19214
CAS No.: 3040055-91-9
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
