2. Anti-infection
  3. Antibiotic Bacterial
  4. Glenthmycin L

Glenthmycin L is a potent antibiotic that can be found in Australian sheep pasture-derived Streptomyces sp. CMB-PB041. Glenthmycin L exhibits antibacterial activity against Gram-positive bacterial pathogens including Staphylococcus aureus, Enterococcus faecalis, Methicillin (HY-B0974)-resistant Staphylococcus aureus, and Vancomycin (HY-B0671)-resistant Enterococci. Glenthmycin L can be used for the research of bacterial infections caused by Gram-positive pathogens.

For research use only. We do not sell to patients.

Glenthmycin L

Glenthmycin L Chemical Structure

CAS No. : 3040055-91-9

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Glenthmycin L Related Antibodies

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Description

Glenthmycin L is a potent antibiotic that can be found in Australian sheep pasture-derived Streptomyces sp. CMB-PB041. Glenthmycin L exhibits antibacterial activity against Gram-positive bacterial pathogens including Staphylococcus aureus, Enterococcus faecalis, Methicillin (HY-B0974)-resistant Staphylococcus aureus, and Vancomycin (HY-B0671)-resistant Enterococci. Glenthmycin L can be used for the research of bacterial infections caused by Gram-positive pathogens[1].

In Vitro

Glenthmycin L (0.01-30 μM; 16-24 h) potently inhibits growth of Staphylococcus aureus (ATCC 25923) with an IC50 of 0.8 μM, methicillin-resistant S. aureus (ATCC 43300) with an IC50 of 0.3 μM, Enterococcus faecalis with an IC50 of 3.0 μM, methicillin-resistant S. aureus (ATCC 33591) with an IC50 of 6.8 μM, and vancomycin-resistant Enterococci with an IC50 of 6.7 μM[1].
Glenthmycin L (30 μM; 48 h) shows no significant cytotoxicity against SW620 human colorectal carcinoma cells or NCI-H460 human lung carcinoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glenthmycin L Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: SW620 human colorectal carcinoma cells, NCI-H460 human lung carcinoma cells
Concentration: 30 μM
Incubation Time: 48 h
Result: Did not exhibit significant cytotoxicity against SW620 or NCI-H460 cells.
Showed no indication of reduced cell viability relative to the negative control.
Molecular Weight

562.75

Formula

C35H46O6
CAS No.
SMILES

OC=1[C@@]23[C@@](C=C(C)[C@H](C)C2)(/C=C(\C)/CC/C=C(\C)/[C@]4([C@@](C)(C(=O)C1C(=O)O3)[C@]5([C@@]([C@@H](OC(C)=O)CC[C@@H]5C)(C=C4C)[H])[H])[H])[H]
Structure Classification
Initial Source

Streptomyces sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Glenthmycin L Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glenthmycin L3040055-91-9AntibioticBacterialhuman carcinoma cellsmethicillin-resistant Staphylococcus aureusSW620 human colorectal carcinoma cellsMycobacterium speciesvancomycin-resistant EnterococciEnterococcus faecalisGram-positive bacterial pathogensStreptomyces sp. CMB-PB041Staphylococcus aureusNCI-H460 human lung carcinoma cellsInhibitorinhibitorinhibit

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