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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
NF-κB1
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "NF-κB1" in MCE Product Catalog:
62
62 Publications Verification
Cat. No.: HY-N0197
CAS No.: 21967-41-9
Synonyms: Baicalein 7-O-β-D-glucuronide
3
3 Cited Publications
Cat. No.: HY-N1993
CAS No.: 82517-12-2
Target:
1
1 Cited Publications
Cat. No.: HY-174138
Target:
Research Areas:
NF-κB degrader 1 (Compound MD-1) is a NF-κB1 p105 subunit degrader. NF-κB degrader 1 shows anti-inflammatory activity (IC50 for inhibiting TNF-α is 2.02 μM, and for inhibiting NO is 5.40 μM). NF-κB degrader 1 induces p105 degradation dependent on the Cullin-RING ligase (CRL) SCFBTCP, suppressing NF-κB transcriptional activity. NF-κB degrader 1 is promising for research of inflammation-related diseases .
1
1 Cited Publications
JS6 is a Bcl3 inhibitor. JS6 attenuates the binding of Bcl3 to NF-κB1 (p50), disrupts the binding of Bcl3 to NF-κB family proteins p50 and p52, and inhibits the NF-κB signaling pathway. JS6 is applicable to breast cancer-related research .
Synonyms: RTA dh404
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Research Areas:
CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB . CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats .
Category:
Flavonoids Chalcones Monophenols Metabolic Disease Phenols Endogenous metabolite Disease Research Fields
Target:
Category:
Coumarins Phenylpropanoids Plants Umbelliferae Pluchea indica (L.) Less. Disease Research Fields Inflammation/Immunology
Target:
Synonyms: Mesalamine-d3; 5-ASA-d3; Mesalazine-d3
Cat. No.: HY-N0197R
CAS No.: 21967-41-9
Synonyms: Baicalein 7-O-β-D-glucuronide (Standard)
Synonyms: Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride
Cat. No.: HY-131265
CAS No.: 887256-40-8
Research Areas:
Mesalamine impurity P is an impurity of Mesalamine (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .
Cat. No.: HY-N7980
CAS No.: 2170211-22-8
Category:
Quinones Rubia podantha Rubiaceae Plants Disease Research Fields Naphthalene Quinones Cancer
Target:
Cat. No.: HY-N9149
CAS No.: 98570-81-1
Target:
Cat. No.: HY-N0052C
CAS No.: 132210-34-5
Synonyms: Sanguinarin (gluconate); Sanguinarium (gluconate); Pseudochelerythrine (gluconate)
Cat. No.: HY-N0001S
CAS No.: 1217780-28-3
Cat. No.: HY-L014
1,770 compounds
Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.
MCE owns a unique collection of 1,770 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
