5-Aminosalicylic acid-d3
Based on 1 Customer Validation
5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
For research use only. We do not sell to patients.
- Purity: 99.38%
- CAS No.: 1309283-32-6
- Formula: C7H4D3NO3
- Molecular Weight:156.15
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1309283-32-6
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Unlabeled Cas 89-57-6
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Appearance Solid
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Molecular Weight 156.15
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Formula C7H4D3NO3
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Color Off-white to gray
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SMILES
OC(C1=C(C([2H])=C([2H])C(N)=C1[2H])O)=O
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Synonyms
Mesalamine-d3; 5-ASA-d3; Mesalazine-d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 66.67 mg/mL (426.96 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60.;Fang HM, et al. 5-aminosalicylic acid in combination with Nimesulide inhibits proliferation of colon carcinoma cells i [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.4041 mL | 32.0205 mL | 64.0410 mL | 160.1025 mL |
| 5 mM | 1.2808 mL | 6.4041 mL | 12.8082 mL | 32.0205 mL | |
| 10 mM | 0.6404 mL | 3.2020 mL | 6.4041 mL | 16.0102 mL | |
| 15 mM | 0.4269 mL | 2.1347 mL | 4.2694 mL | 10.6735 mL | |
| 20 mM | 0.3202 mL | 1.6010 mL | 3.2020 mL | 8.0051 mL | |
| 25 mM | 0.2562 mL | 1.2808 mL | 2.5616 mL | 6.4041 mL | |
| 30 mM | 0.2135 mL | 1.0673 mL | 2.1347 mL | 5.3367 mL | |
| 40 mM | 0.1601 mL | 0.8005 mL | 1.6010 mL | 4.0026 mL | |
| 50 mM | 0.1281 mL | 0.6404 mL | 1.2808 mL | 3.2020 mL | |
| 60 mM | 0.1067 mL | 0.5337 mL | 1.0673 mL | 2.6684 mL | |
| 80 mM | 0.0801 mL | 0.4003 mL | 0.8005 mL | 2.0013 mL | |
| 100 mM | 0.0640 mL | 0.3202 mL | 0.6404 mL | 1.6010 mL |
5-Aminosalicylic acid-d3 Related Classifications
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