581-31-7
581-31-7
Chemical Structure
Suberosin
- CAS 番号: 581-31-7
- Formula:C15H16O3
- Molecular Weight:244.29
IUPAC Name: 7-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-2-one
InChIKey: RSZDAYHEZSRVHS-UHFFFAOYSA-N
SMILES: O=C1C=CC2=CC(C/C=C(C)\C)=C(OC)C=C2O1
Biological Activity: Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB[1][2].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Suberosin | 99.84% | Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB. | ||||||||||||||||||||
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Osthole | 99.98% | Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells. | ||||||||||||||||||||
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Apigravin | Apigravin is a potent antibacterial agent. Apigravin shows antibacterial activity against Bacillus subtilis with a MIC value of 61 μM. | |||||||||||||||||||||
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Prenyletin | 99.58% | Prenyletin is a natural product, that can be isolated from the roots of Ptaeroxylon obliquum Radlk. (Rutaceae). Prenyletin shows anti-oxidative stress activity. | ||||||||||||||||||||
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7-O-Prenylscopoletin | 7-O-Prenylscopoletin is a natural product. | |||||||||||||||||||||
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Demethylsuberosin | 99.71% | Demethylsuberosin (7-Demethylsuberosin) is a coumarin compound found in Angelica gigas Nakai. Demethylsuberosin exerts antihypertensive effects by inhibiting the L-type CaV1.2 channel. Demethylsuberosin has antioxidant and anti-inflammatory activities. Demethylsuberosin also exhibits neuroprotective activities against glutamate-induced toxicity in primary cultured rat cortical cells. | ||||||||||||||||||||
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7-Hydroxy-3-prenylcoumarin | 7-Hydroxy-3-prenylcoumarin is a Coumarins product that can be isolated from the herbs of Coriaria nepalensis. | |||||||||||||||||||||
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7-Hydroxy-6-methoxy-3-prenylcoumarin | 7-Hydroxy-6-methoxy-3-prenylcoumarin is a Coumarins product that can be isolated from the herbs of Coriaria nepalensis. | |||||||||||||||||||||
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Dehydrogeijerin | Dehydrogeijerin is an inhibitor of acetylcholinesterase with an IC50 of 9.7 μM. Dehydrogeijerin can be used in study Alzheimer’s disease. | |||||||||||||||||||||
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Toddaculin | 99.73% | Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity. | ||||||||||||||||||||
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Ostruthin | 98.84% | Ostruthin is a natural coumarin compound with bacterial and antimycobacterial activities. Ostruthin inhibits the growth of mycobacteria and Staphylococcus aureus. Ostruthin suppresses vascular smooth muscle cell proliferation as well as de novo cellular DNA synthesis. Ostruthin is applicable to research related to mycobacterial infections and cardiovascular and cerebrovascular diseases. | ||||||||||||||||||||
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References
- [1]. Y-C Chen, et al. Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-jB. British Journal of Pharmacology (2007) 150, 298-312.
- [2]. Golfakhrabadi F, et al. Anticoagulant activity of isolated coumarins (suberosin and suberenol) and toxicity evaluation of Ferulago carduchorum in rats. Pharm Biol. 2014 Oct;52(10):1335-40. [Content Brief]
