107 Results for "

Na _K ATPase

" in MedChemExpress (MCE) Product Catalog:
Products (107)

107 Results for "Na _K ATPase" in MCE Product Catalog:

75
75 Publications Verification
Cat. No.: HY-N1446
CAS No.: 112-80-1
Synonyms: 9-cis-Octadecenoic acid; 9Z-Octadecenoic acid
Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na +/K + ATPase activator .
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75
75 Publications Verification
Cat. No.: HY-N1446B
CAS No.: 143-19-1
Synonyms: Sodium oleate; 9-cis-Octadecenoic acid sodium; 9Z-Octadecenoic acid sodium
Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium . Sodium oleate is a Na +/K + ATPase activator .
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20
20 Cited Publications
Cat. No.: HY-D0085
CAS No.: 53213-94-8
DiSC3(5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3(5) is up to 622/670 nm. DiSC3(5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC50 value is 8 μM. DiSC3(5) in the presence of Na +/K +-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells .
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16
16 Cited Publications
Cat. No.: HY-N0039
CAS No.: 41753-43-9
Synonyms: Gypenoside III
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na +, K +-ATPase activity with an IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .
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11
11 Cited Publications
Cat. No.: HY-N0877
CAS No.: 465-21-4
Bufalin is an active component isolated from Chan Su, acts as a potent Na +/K +-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively . Anti-cancer activity .
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6
6 Cited Publications
Cat. No.: HY-N1381
CAS No.: 13137-64-9
Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .
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6
6 Cited Publications
Cat. No.: HY-13719
CAS No.: 465-16-7
Purity:  99.91%
Synonyms: PBI-05204
Oleandrin (PBI-05204) inhibits the Na +, K +-ATPase activity with an IC50 of 620 nM.
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6
6 Cited Publications
Cat. No.: HY-15718A
CAS No.: 374559-48-5
Purity:  99.28%
Synonyms: PST2744 hydrochloride
Research Areas:  

Cardiovascular Disease

Istaroxime hydrochloride is a Na +/K +-ATPase inhibitor (IC50=0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
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4
4 Cited Publications
Cat. No.: HY-N2070
CAS No.: 25161-41-5
Acevaltrate inhibits the Na +/K +-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8 μM and 42.3 μM, respectively .
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2
2 Cited Publications
Cat. No.: HY-12283
CAS No.: 156722-18-8
Purity:  99.03%
Synonyms: PST 2238
Target:  

Na+/K+ ATPase RSV

Research Areas:  

Cardiovascular Disease

Rostafuroxin (PST 2238), a digitoxigenin derivative, is an orally active and potent Na +,K +-ATPase (ATP1A1) antognist. Rostafuroxin binds specifically to the ATP1A1 extracellular domain and blocks respiratory syncytial virus (RSV)-triggered EGFR Tyr845 phosphorylation. Rostafuroxin has antihypertensive and anti-RSV activity .
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2
2 Cited Publications
Cat. No.: HY-114252
CAS No.: 66-28-4
Purity:  93.31%
Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca 2+ concentration .
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2
2 Cited Publications
Cat. No.: HY-100414
CAS No.: 261944-46-1
Purity:  99.78%
Synonyms: BYK61359
Target:  

Proton Pump

Research Areas:  

Metabolic Disease

Soraprazan (BYK61359) is a selective, reversible K-competitive inhibitor of the H,K-ATPase (Ki=6.4 nM), with an IC50 of 0.19 μM in gastric glands. Soraprazan binds to the H,K-ATPase with a Kd of 28.27 nM. Soraprazan shows immediate inhibition of acid secretion and is more than 2000-fold selective for H,K-ATPase over Na,K- and Ca-ATPases .
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2
2 Cited Publications
Cat. No.: HY-P3278
CAS No.: 350670-85-8
Target:  

Proton Pump

Research Areas:  

Metabolic Disease

Caloxin 2A1 is an extracellular plasma membrane Ca 2+-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 does not affect basal Mg 2+-ATPase or Na +-K +-ATPase .
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2
2 Cited Publications
Cat. No.: HY-105416
CAS No.: 121263-19-2
Purity:  99.00%
Synonyms: UCN-1028C
Target:  

Antibiotic PKC Apoptosis

Research Areas:  

Metabolic Disease Cancer

Calphostin C is a highly selective PKC inhibitor (IC50=0.05 μM) and tumor apoptosis inducer. Calphostin C competitively binds to PKC and inhibits PKC-mediated phosphorylation signal transduction. Calphostin C restores Na+/K+ ATPase activity in the sciatic nerve of diabetic mice and improves neuropathy. Calphostin C can be used in the study of anti-tumor and diabetic complications .
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2
2 Cited Publications
Cat. No.: HY-P3278A
Target:  

Proton Pump

Research Areas:  

Metabolic Disease

Caloxin 2A1 TFA is an extracellular plasma membrane Ca 2+-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 TFA does not affect basal Mg 2+-ATPase or Na +-K +-ATPase .
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2
2 Cited Publications
Cat. No.: HY-N10424
CAS No.: 600-76-0
Brazilein is a compound with anti-inflammatory and neuroprotective activities, with an IC50 of 500 μM against guinea pig Na +,K +-ATPase. Brazilein reduces iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells. Brazilein suppresses inflammatory responses by reducing the mRNA expression of TNF-α and IL-6, but has no effect on IL-1β expression. Brazilein reduces the cerebral infarction volume and improves the neurological function scores of rats with cerebral ischemia-reperfusion injury. Brazilein induces apoptosis of splenic lymphocytes in mice. Brazilein inhibits humoral immune responses in mice, and causes thymus and spleen atrophy as well as body weight loss in mice. Brazilein also possesses antimalarial and antibacterial activities. Brazilein is also a red dye. Brazilein can be used in studies related to the infection, nervous system, cardiovascular system and inflammatory diseases .
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1
1 Cited Publications
Cat. No.: HY-N1446S2
CAS No.: 287100-82-7
Synonyms: 9-cis-Octadecenoic acid-13C18; 9Z-Octadecenoic acid-13C18
Oleic acid- 13C18 is the 13C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .
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1
1 Cited Publications
Cat. No.: HY-N1446S1
CAS No.: 5711-29-5
Synonyms: 9-cis-Octadecenoic acid-d2; 9Z-Octadecenoic acid-d2
Oleic acid-d2) is the deuterium labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid ]. Oleic acid is a Na+/K+ ATPase activator .
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1
1 Cited Publications
Cat. No.: HY-P5712
CAS No.: 113-73-5
Synonyms: Gramicidin soviet
Research Areas:  

Infection

Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na +/K +-ATPase, tobacco leaf plasma membrane Mg 2+/K +-ATPase, and rat heart plasma membrane Ca 2+-ATPase, respectively .
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1
1 Cited Publications
Cat. No.: HY-B0137
CAS No.: 721-50-6
Target:  

Na+/K+ ATPase

Research Areas:  

Neurological Disease

Prilocaine, an amino amide, is a Na/K-ATPase inhibitor. Prilocaine has neurotoxic effects .
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