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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
35 Results for "
O-acyltransferase
" in MedChemExpress (MCE) Product Catalog:
Products (35)
35 Results for "O-acyltransferase" in MCE Product Catalog:
36
36 Publications Verification
Target:
Research Areas:
IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ .
4
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Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical cancer .
4
4 Cited Publications
Synonyms: PD-132301 hydrochloride; ATR101 hydrochloride
Target:
Research Areas:
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer .
3
3 Cited Publications
Target:
Research Areas:
DGAT1-IN-1 is a diacylglycerol O-acyltransferase 1 (DGAT1) inhibitor with a human IC50 of <10 nM and a mouse IC50 of <50 nM. DGAT1-IN-1 is applicable to the research of obesity-related diseases, type 2 diabetes and diabetes-related diseases .
1
1 Cited Publications
Category:
Cardiovascular Disease Microorganisms Terpenoids Sesquiterpenes Disease Research Fields Inflammation/Immunology
Target:
1
1 Cited Publications
Cat. No.: HY-13912G
CAS No.: 686770-61-6
1
1 Cited Publications
Cat. No.: HY-E70255
CAS No.: 799813-02-8
Synonyms: Hexacosanoyl coenzyme A triammonium
Target:
Research Areas:
26:0 Coenzyme A (Hexacosanoyl coenzyme A triammonium) is a type of coenzyme A that can serve as a substrate for 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11 (AGPAT11) .
1
1 Cited Publications
Cat. No.: HY-P704076
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PNPLA3; Calcium-Independent Phospholipase A2-Epsilon; Prev. C22orf20; Acylglycerol Transacylase; Prev. ADPN; IPLA2-Epsilon; Adiponutrin; DJ796I17.1; Patatin Like Domain 3, 1-Acylglycerol-3-Phosphate O-acyltransferase; FLJ22012; Patatin-Like Phospholipase
Species:
Human
Source:
Sf9 insect cells
Synonyms: RXC004
Target:
Research Areas:
Zamaporvint (RXC004) is an orally active and selective inhibitor of Wnt. Zamaporvint targete membrane-bound o-acyltransferase Porcupine and inhibited Wnt ligand palmitoylation, secretion, and pathway activation. Zamaporvint displays a favorable pharmacokinetic profile and shows potent antiproliferative effects in Wnt ligand-dependent colorectal and pancreatic cell lines. Zamaporvint possesses multiple antitumor mechanisms and can be used in cancer research .
Synonyms: sn-1,2-Dioleoylglycerol; 18:1/18:1-DG
Cat. No.: HY-16437
CAS No.: 135239-65-5
Target:
Research Areas:
RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors.
Cat. No.: HY-19286
CAS No.: 202340-45-2
Synonyms: F 12511
Target:
Research Areas:
Eflucimibe (F 12511) is a new acyl-coenzyme A cholesterol O-acyltransferase (ACAT) inhibitor. Eflucimibe can be used in the research of atherosclerosis .
Cat. No.: HY-169813
CAS No.: 81840-57-5
Target:
Cat. No.: HY-E71377
Target:
Research Areas:
1-Alkylglycerophosphocholine O-acyltransferase (EC 2.3.1.63) is an acyltransferase involved in the biosynthesis of ether lipids.
Cat. No.: HY-E71373
Target:
Research Areas:
1-Alkenylglycerophosphoethanolamine O-acyltransferase (EC 2.3.1.121): long-chain unsaturated acyl-CoAs are the best substrates.
Cat. No.: HY-E71465
Target:
Research Areas:
2-Acylglycerophosphocholine O-acyltransferase (EC 2.3.1.62) belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups.
Cat. No.: HY-177628A
Edutirsen sodium, an antisense oligonucleotide, is a 1-acylglycerol-3-phosphate O-acyltransferase (PNPLA3) synthesis reducer.
Cat. No.: HY-E71464
Target:
Research Areas:
2-Acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.52): saturated acyl-CoA thioesters are the most effective acyl donors.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
