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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
PROTAC HIV-1 degrader-1
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "PROTAC HIV-1 degrader-1" in MCE Product Catalog:
製品番号: HY-187361
CAS 番号: 3107740-33-7
PROTAC HIV-1 degrader-1 is a HIV-1 capsid (CA) PROTAC degrader, with a DC50 of 3 nM against HIV-1IIIB (MT‑4 cells) and a DC50 of 1.17 nM against HIV-1NL4-3 (MT‑4 cells). PROTAC HIV-1 degrader-1 conjugates HIV-1 capsid (CA) with the VHL E3 ubiquitin ligase, triggering polyubiquitination and proteasome-mediated degradation of CA, as well as competitively inhibiting the binding of host factors CPSF6 and Sec24C to CA. PROTAC HIV-1 degrader-1 degrades CA drug-resistant mutants (N74D, K70R). PROTAC HIV-1 degrader-1 is applicable to research related to HIV-1 infection .
製品番号: HY-163852
CAS 番号: 2801703-79-5
HIV-1 inhibitor-72 (compound 5m) is a target protein ligand of PROTAC Vif degrader-1 (HY-163851). HIV-1 inhibitor-72 is a potent HIV-1 inhibitor .
製品番号: HY-187362
CAS 番号: 3107740-50-8
研究分野:
HIV-1 ligand-1 (IIA-5) is a PROTAC target protein ligand. HIV-1 ligand-1 can be used for the synthesis of PROTAC HIV-1 degrader-1 (HY-187361) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
