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Results for "

RNA nucleotides

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (25) MicroRNA (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Antifolate (2) Apoptosis (7) Arenavirus (1) Bacterial (3) Bcl-2 Family (1) Biochemical Assay Reagents (1) Caspase (1) CCR (2) DNA Alkylator/Crosslinker (2) Drug Derivative (1) Drug Intermediate (1) Endogenous Metabolite (29) Eukaryotic Initiation Factor (eIF) (3) Exosomes (3) Fluorescent Dye (2) Fungal (1) HCV (3) Histone Methyltransferase (1) HSV (2) Isotope-Labeled Compounds (10) Mitosis (6) Nucleoside Antimetabolite/Analog (13) P2Y Receptor (3) Parasite (1) Phosphoramidites (1) Potassium Channel (3) Reference Standards (7) Toll-like Receptor (TLR) (2) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (1) Infection (15) Inflammation/Immunology (5) Metabolic Disease (28) Neurological Disease (3)
Click Chemistry:	Azide (2)
Oligonucleotides:	Adenosine (1) Guanine Nucleotide (1) Nucleoside Analogs (2) Aptamers (4) Nucleotide Analogs (11) CpG ODNs (1) Uridine (1) Cytosine (1) Uracil Nucleotide (1) Antisense Oligonucleotides (1) Phosphoramidites (1) Adenine Nucleotide (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: MicroRNA mRNA RNA MTase Small Interfering RNA (siRNA) DNA/RNA Synthesis Aminoacyl-tRNA Synthetase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108666

ATPγS tetralithium salt 1 Publications Verification Adenosine-5'-O-3-thiotriphosphate tetralithium salt; Adenosine 5'-[γ-thio]triphosphate tetralithium salt	Eukaryotic Initiation Factor (eIF) P2Y Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology
ATPγS (tetralithium salt) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATPγS (tetralithium salt) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATPγS (tetralithium salt) is active in ATP hydrolysis .

HY-W010737

Guanosine-5'-triphosphate disodium salt Maximum Cited Publications 8 Publications Verification 5'-GTP disodium salt	Exosomes Endogenous Metabolite MicroRNA	Metabolic Disease
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

HY-N0157

Orotic acid 3 Publications Verification 6-Carboxyuracil; Vitamin B13	Nucleoside Antimetabolite/Analog Endogenous Metabolite	Metabolic Disease
Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats .

HY-12695

Guanosine 5'-triphosphate trisodium 5 Publications Verification 5'-GTP trisodium	Exosomes Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate trisodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

HY-13560

AVN-944 5 Publications Verification VX-944	Arenavirus DNA/RNA Synthesis Apoptosis Caspase Bcl-2 Family	Infection Cancer
AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor of IMPDH (inosine monophosphate dehydrogenase). AVN-944 is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. AVN-944 is also an inhibitor of *arenavirus RNA* synthesis**, and blocks arenavirus infection. AVN-944 has broad anti-cancer activities, and can be used for multiple myeloma (MM) and acute myeloid leukemia (AML) research .

HY-W009162

Cytidine 5'-monophosphate 1 Publications Verification 5'-Cytidylic acid; 5'-CMP	Endogenous Metabolite	Metabolic Disease
Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group .

HY-164899

2A3 2-aminopyridine-3-carboxylic acid imidazolide	Transmembrane Glycoprotein	Cancer
2A3 (2-aminopyridine-3-carboxylic acid imidazolide) is a T cell activator that specifically binds to CEACAM6 and CEACAM5. 2A3 exhibits enzymatic activity that catalyzes the glucuronidation of specific substrates (e.g., 1-naphthol), and possesses significant cytotoxic activity. When integrated into CAR T cells or used alone, 2A3 acts by inducing cytokine release, degranulation, and direct cytotoxicity. 2A3 kills pancreatic and breast cancer cells with high target antigen expression in vitro, and significantly inhibits the growth of pancreatic cancer xenografts in vivo. 2A3 broadly targets malignant tumors with overexpressed CEACAM5, CEACAM6, or co-expressed both, and shows high expression mainly in tissues such as the liver and colon. 2A3 serves as an important research tool for the immunotherapy of pancreatic and breast cancer . 2A3 is a novel SHAPE reagent, which can be used for the analysis of RNA structure both in vitro and in vivo . 2A3 is an electrophilic chemical probe that acylates the 2'-OH in the RNA backbone. 2A3 can be used for RNA SHAPE-MaP experiments and is capable of analyzing the RNA secondary structures at single nucleotide resolution.

HY-W009444

5-Methyluridine 1 Publications Verification	Endogenous Metabolite	Others
5-Methyluridine (m ⁵U) is an RNA modified nucleotide generated by RNA methyltransferases (such as TrmA and RumA), which mainly targets specific uracil sites in RNA molecules such as the T arm of tRNA and rRNA. 5-Methyluridine relies on enzyme recognition of RNA secondary/tertiary structures (such as the T loop of tRNA or the specific stem-loop structure of rRNA) and participates in physiological processes such as translation accuracy and ribosome function by stabilizing RNA folding or regulating base pairing .

HY-D0913

1-Methyl-7-nitroisatoic anhydride 3 Publications Verification 1M7	Fluorescent Dye	Others
1-Methyl-7-nitroisatoic anhydride (1M7) is a reagent that detects local nucleotide flexibility, for probing 2'-hydroxyl reactivity, can be used for RNA structure analysis .

HY-12695B

Guanosine 5'-triphosphate trisodium salt hydrate Maximum Cited Publications 8 Publications Verification 5'-GTP trisodium salt hydrate	Exosomes Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease
Guanosine 5'-triphosphate (5'-GTP) trisodium salt hydrate is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt hydrate can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt hydrate holds promise for research in biosynthesis and skeletal muscle regeneration .

HY-76222

Isatoic anhydride	Drug Intermediate	Others
Isatoic anhydride is a single-adduct forming reagent and a monofunctional SHAPE reagent. Isatoic anhydride reacts with the 2'-hydroxyl group of RNA nucleotides via a single reactive group to form a single adduct, without forming cross-links between nucleotides. In SHAPE-JuMP experiments, Isatoic anhydride serves as a control reagent for single-adduct formation, which is used to distinguish true cross-links from single-adduct formation .

HY-153845

RNA Aptamer Broccoli sodium	Biochemical Assay Reagents	Others
RNA Aptamer Broccoli sodium is a 49-nucleotide nucleic acid aptamer that is much shorter than Spinach and Spinach2. It exhibits bright green fluorescence when binding to DFHBI or DFHBI-1T (a soluble analog of the green fluorescent protein label). RNA Aptamer Broccoli sodium can be used for RNA expression or localization in living cells .

HY-113226

Orotidine 1 Publications Verification	Endogenous Metabolite	Others
Orotidine, a nucleotide, is an intermediate in pyrimidine nucleotide biosynthesis in RNA and DNA. Orotidine is mainly found in bacteria, fungi and plants .

HY-113138

3-Methyluridine 1 Publications Verification N3-Methyluridine	Endogenous Metabolite	Metabolic Disease
3-Methyluridine (m ³U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance .

HY-W011548

2-Aminoadenosine	Nucleoside Antimetabolite/Analog	Others
2-Aminoadenosine is a modified adenine base and adenosine analog that stabilizes RNA duplexes and enhances template-directed nucleotide condensation reactions. 2-Aminoadenosine forms three hydrogen bonds with uracil to increase the melting temperature of hybrid strands, thereby stabilizing uracil-containing RNA duplexes .

HY-148100

Emapticap pegol 1 Publications Verification NOX-E36	CCR	Inflammation/Immunology Cancer
Emapticap pegol (NOX-E36) is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36). mNOX-E36 is a murine-specific analogue of NOX-E36, an anti-MCP-1 L-RNA aptamer that was previously shown to attenuate liver fibrosis in mice .

HY-113225

Guanosine triphosphate GTP	Endogenous Metabolite DNA/RNA Synthesis Apoptosis Mitosis	Cancer
Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-148688

ASO 556089 sodium	DNA/RNA Synthesis	Others
ASO 556089 sodium is a 16 nucleotide length gapmer (3-10-3) that targets the human and mouse long non-coding RNA MALAT1, with the sequence: 5’-GmCATTmCTAATAGmCAGmC-3’ .

HY-152038

SPEN-IN-1	Histone Methyltransferase	Others
SPEN-IN-1 (compound X1) is an inhibitor of SPEN which is a protein factor with a K_d value of 47 nM. SPEN-IN-1 has high selectivity for RepA, a 431-nucleotide domain in Xist (a non-coding RNA prototype) that comprises 8.5 units of a GC-rich motif responsible for gene silencing .

HY-135780A

3'-Deoxyuridine-5'-triphosphate trisodium 3'-dUTP trisodium	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite	Metabolic Disease
3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into *RNA* with a K_i value of 2.0 μM .

HY-112581B

5-Methoxyuridine 5'-triphosphate trisodium solution (100 mM) 5-Methoxy-UTP trisodium solution (100 mM); 5-OMe-UTP trisodium solution (100 mM)	DNA/RNA Synthesis	Others
5-Methoxyuridine 5'-triphosphate trisodium solution (100 mM) is a modified nucleotide triphosphate (NTP). 5-Methoxyuridine 5'-triphosphate trisodium can be added into mRNA with T7 RNA polymerase .

HY-16398

Pipobroman	DNA Alkylator/Crosslinker DNA/RNA Synthesis	Cancer
Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al .

HY-160230

ssRNA41 sodium	Toll-like Receptor (TLR)	Infection
ssRNA41 sodium is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. It derives from ssRNA40 by replacement of all U nucleotides with adenosine. ssRNA41 sodium is unable to induce the production of type IFNs, and therefore can be used as a negative control for ssRNA40 .

HY-N0157R

Orotic acid (Standard) 6-Carboxyuracil (Standard); Vitamin B13 (Standard)	Reference Standards Nucleoside Antimetabolite/Analog Endogenous Metabolite	Metabolic Disease
Orotic acid (Standard) is the analytical standard of Orotic acid. This product is intended for research and analytical applications. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats .

HY-129963

3'-UMP disodium	Endogenous Metabolite DNA/RNA Synthesis	Others
3'-UMP disodium is a nucleotide, that is a component of ribonucleic acid (RNA) and would be converted to uracil in rat jejunum .

HY-148100A

Emapticap pegol sodium 1 Publications Verification NOX-E36 sodium	CCR	Cancer
Emapticap pegol sodium is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol sodium is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) .

HY-160231

ssRNA42 sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
ssRNA42 (sodium) is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. ssRNA42 (sodium) derives from ssRNA40 by replacement of all G nucleotides with adenosine. ssRNA42 activated human PBMCs to secrete IFN-α, TNF-a, IL- 12p40, and IL-6, but ssRNA42 failed to stimulated murine pDCs and PBMCs.

HY-113225S2

Guanosine triphosphate-13C dilithium GTP-13C dilithium	Isotope-Labeled Compounds Endogenous Metabolite Mitosis Apoptosis DNA/RNA Synthesis	Infection Cancer
Guanosine triphosphate- ¹³C (GTP- ¹³C) dilithium is ¹³C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113225S3

Guanosine triphosphate-15N5 dilithium GTP-15N5 dilithium	Isotope-Labeled Compounds Endogenous Metabolite Mitosis Apoptosis DNA/RNA Synthesis	Infection Cancer
Guanosine triphosphate- ¹⁵N₅ (GTP- ¹⁵N₅) dilithium is ¹⁵N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate dilithium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate dilithium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate dilithium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate dilithium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate dilithium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113225S5

Guanosine triphosphate-13C10 dilithium GTP-¹³C₁₀ dilithium	Isotope-Labeled Compounds Endogenous Metabolite Mitosis Apoptosis DNA/RNA Synthesis	Infection Cancer
Guanosine triphosphate- ¹³C₁₀ (GTP- ¹³C₁₀) dilithium is ¹³C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate dilithium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate dilithium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate dilithium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate dilithium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate dilithium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-W009162S5

Cytidine 5′-monophosphate-13C9,15N3 dilithium 5'-Cytidylic acid-13C9,15N3 dilithium; 5'-CMP-13C9,15N3 dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Cytidine 5′-monophosphate- ¹³C₉, ¹⁵N₃ (5'-Cytidylic acid- ¹³C₉, ¹⁵N₃ dilithium; 5'-CMP- ¹³C₉, ¹⁵N₃) dilithium is ¹³C and ¹⁵N-labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.

HY-134320B

8-Azido-ATP trisodium solution (100 mM) 8-Azidoadenosine 5'-triphosphate trisodium; 8-N3-ATP trisodium	Potassium Channel	Metabolic Disease
8-Azido-ATP (8-N3-ATP) trisodium, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase. 8-Azido-ATP trisodium is a click chemistry reagent that contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. 8-Azido-ATP trisodium can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-N0157A

Orotic acid zinc 3 Publications Verification 6-Carboxyuracil zinc; Vitamin B13 zinc	Nucleoside Antimetabolite/Analog Endogenous Metabolite	Metabolic Disease
Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats .

HY-W042357

Ac-rC Phosphoramidite	Phosphoramidites DNA/RNA Synthesis	Others
Ac-rC Phosphoramidite is a cytosine phosphoramidite used in the chemical synthesis of RNA oligonucleotides. Ac-rC Phosphoramidite enables the incorporation of cytidine nucleotides into synthetic RNA strands, and its unique protecting groups ensure the structural integrity of the molecule throughout complex synthetic processes .

HY-103396

Trimetrexate glucuronate 2 Publications Verification CI-898 glucuronate	Antifolate Bacterial	Infection Cancer
Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia .

HY-134361

ATP-γ-S tetrasodium	P2Y Receptor Eukaryotic Initiation Factor (eIF)	Neurological Disease Metabolic Disease Inflammation/Immunology
ATP-γ-S (tetrasodium) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATP-γ-S (tetrasodium) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATP-γ-S (tetrasodium) is active in ATP hydrolysis .

HY-134320

8-Azido-ATP 8-Azidoadenosine 5'-triphosphate; 8-N3-ATP	Potassium Channel	Metabolic Disease
8-Azido-ATP, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase . 8-Azido-ATP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-D3010

VF dsDNA Green Dye	Fluorescent Dye	Others
VF dsDNA Green Dye is a fluorescent dye for detecting and quantifying double-stranded DNA (dsDNA). VF dsDNA Green Dye fluoresces only when bound to dsDNA, and the fluorescence intensity is proportional to the DNA concentration. VF dsDNA Green Dye does not fluoresce when bound to ssDNA, RNA, or free nucleotides. VF dsDNA Green Dye can detect dsDNA within the range of 25 pg/mL to 1000 ng/mL (Ex/Em = 480/520 nm).

HY-135780

3'-Deoxyuridine-5'-triphosphate 3'-dUTP	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite	Metabolic Disease
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into *RNA* with a K_i value of 2.0 μM .

HY-109047

Adafosbuvir AL-335	HCV DNA/RNA Synthesis	Infection
Adafosbuvir (AL-335), a precursor compound of a uridine-based nucleotide analog polymerase (NS5B) inhibitor, has potent antiviral activity against HCV and acts as a potent inhibitor of HCV RNA polymerase .

HY-W009162R

Cytidine 5'-monophosphate (Standard) 5'-Cytidylic acid (Standard); 5'-CMP (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Cytidine 5'-monophosphate (Standard) is the analytical standard of Cytidine 5'-monophosphate. This product is intended for research and analytical applications. Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group .

HY-N0157S1

Orotic acid-13C,15N2 monohydrate 6-Carboxyuracil-13C,15N2 monohydrate; Vitamin B13-13C,15N2 monohydrate	Nucleoside Antimetabolite/Analog Endogenous Metabolite	Metabolic Disease
Orotic acid- ¹³C, ¹⁵N₂ (monohydrate) is the ¹³C and ¹⁵N labeled Orotic acid . Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats .

HY-E70091

T4 RNA ligase	DNA/RNA Synthesis	Others
T4 RNA ligase is an ATP-dependent RNA ligase that can catalyze the formation of phosphodiester bonds between the 5'-P end and the 3'-OH end of single-stranded RNA, single-stranded DNA or single nucleotides between molecules or within molecules. T4 RNA ligase is used for enzymatic low ribonucleotide synthesis and 3′ end labeling of RNA. It is mainly used for RNA and RNA, but can also be used for RNA and single nucleotides .

HY-113225S1

Guanosine triphosphate-13C10,15N5 tetraammonium solution (100 mM) GTP-¹³C₁₀,¹⁵N₅ tetraammonium	Endogenous Metabolite Mitosis Apoptosis DNA/RNA Synthesis	Cancer
Guanosine triphosphate- ¹³C₁₀, ¹⁵N₅ tetraammonium is the ¹³C and ¹⁵N labeled Guanosine triphosphate tetraammonium. Guanosine triphosphate tetraammonium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate tetraammonium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate tetraammonium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate tetraammonium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate tetraammonium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113225S4

Guanosine triphosphate-15N5,d14 dilithium GTP-15N5,d14 dilithium	Isotope-Labeled Compounds Endogenous Metabolite Mitosis Apoptosis DNA/RNA Synthesis	Infection Cancer
Guanosine triphosphate- ¹⁵N₅,d₁₄ (GTP- ¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate dilithium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate dilithium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate dilithium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate dilithium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate dilithium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-126877

3-Deaza-2'-deoxyadenosine	HSV	Infection
3-Deaza-2 '-deoxyadenosine is a nucleoside analog synthesized from 2' -deoxyadenosine. 3-Deaza-2 '-deoxyadenosine inhibits RNA synthesis by binding to ribose fragments of ribonucleotides, thereby preventing the formation of enzyme-substrate complexes, thereby preventing chain elongation, It can also inhibit DNA synthesis by binding deoxyribose fragments of DNA and preventing DNA polymerase from adding nucleotides to the growth chain. 3-Deaza-2 '-deoxyadenosine has antiviral activity .

HY-157091

Uridine, 5'-P,P',P'',P''-tetrahydrogen imidotriphosphate	Nucleoside Antimetabolite/Analog	Others
Uridine, 5'-(P,P',P'',P''-tetrahydrogen imidotriphosphate) is a non-hydrolyzable nucleotide that can synthesize RNA oligonucleotides .

HY-177708

N-Acetyltryptamine α-D-Glucose-3-phosphate	Nucleoside Antimetabolite/Analog	Infection Cancer
N-Acetyltryptamine α-D-Glucose-3-phosphate (Compound 30) a nucleotide analogue. N-Acetyltryptamine α-D-Glucose-3-phosphate can modify RNA and enhance its stability.by covalently connecting modular glucose nucleotides. N-Acetyltryptamine α-D-Glucose-3-phosphate can be used for the researches of cancer and infection .

HY-174295

Guanosine 5'-diphosphate-7'N-Me-Imidazole disodium	Drug Derivative	Others
Guanine nucleotide imidazolide intermediate (Compound 19e) disodium is a guanine nucleotide derivative that can be used to synthesize modified RNA .

HY-131561

Ara-UTP Ara-uridine triphosphate	DNA/RNA Synthesis	Others
Ara-UTP is a sugar-modified nucleotide triphosphate that deceives RNA polymerases and blocks chain extension.

Cat. No.	Product Name

HY-L044

Nucleotide Compound Library

572 compounds

Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications.

MCE offers a unique collection of 572 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

Cat. No.	Product Name	Type

HY-D0913

1-Methyl-7-nitroisatoic anhydride 3 Publications Verification 1M7	Fluorescent Dyes
1-Methyl-7-nitroisatoic anhydride (1M7) is a reagent that detects local nucleotide flexibility, for probing 2'-hydroxyl reactivity, can be used for RNA structure analysis .

HY-D3010

VF dsDNA Green Dye

Fluorescent Dyes

VF dsDNA Green Dye is a fluorescent dye for detecting and quantifying double-stranded DNA (dsDNA). VF dsDNA Green Dye fluoresces only when bound to dsDNA, and the fluorescence intensity is proportional to the DNA concentration. VF dsDNA Green Dye does not fluoresce when bound to ssDNA, RNA, or free nucleotides. VF dsDNA Green Dye can detect dsDNA within the range of 25 pg/mL to 1000 ng/mL (Ex/Em = 480/520 nm).

Cat. No.	Product Name	Type

HY-112581B

5-Methoxyuridine 5'-triphosphate trisodium solution (100 mM) 5-Methoxy-UTP trisodium solution (100 mM); 5-OMe-UTP trisodium solution (100 mM)	Biochemical Assay Reagents
5-Methoxyuridine 5'-triphosphate trisodium solution (100 mM) is a modified nucleotide triphosphate (NTP). 5-Methoxyuridine 5'-triphosphate trisodium can be added into mRNA with T7 RNA polymerase .

HY-155743A

ddUTP lithium, 100 mM in H2O 2',3'-Dideoxyuridine-5'-triphosphate lithium	Biochemical Assay Reagents
ddUTP (lithium), 100 mM in H₂O is a nucleotide analog that can be incorporated into DNA, RNA, or other nucleic acids. ddUTP (lithium), 100 mM in H₂O can be used to prepare DNA/RNA hybridization experiments, such as Southern blots and Northern blots.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W010737

Guanosine-5'-triphosphate disodium salt Maximum Cited Publications 8 Publications Verification 5'-GTP disodium salt	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Exosomes Endogenous Metabolite MicroRNA
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

HY-N0157

Orotic acid 3 Publications Verification 6-Carboxyuracil; Vitamin B13	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields	Nucleoside Antimetabolite/Analog Endogenous Metabolite
Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats .

HY-12695

Guanosine 5'-triphosphate trisodium 5 Publications Verification 5'-GTP trisodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Exosomes Endogenous Metabolite DNA/RNA Synthesis
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate trisodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

HY-W009162

Cytidine 5'-monophosphate 1 Publications Verification 5'-Cytidylic acid; 5'-CMP	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group .

HY-W009444

5-Methyluridine 1 Publications Verification	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
5-Methyluridine (m ⁵U) is an RNA modified nucleotide generated by RNA methyltransferases (such as TrmA and RumA), which mainly targets specific uracil sites in RNA molecules such as the T arm of tRNA and rRNA. 5-Methyluridine relies on enzyme recognition of RNA secondary/tertiary structures (such as the T loop of tRNA or the specific stem-loop structure of rRNA) and participates in physiological processes such as translation accuracy and ribosome function by stabilizing RNA folding or regulating base pairing .

HY-12695B

Guanosine 5'-triphosphate trisodium salt hydrate Maximum Cited Publications 8 Publications Verification 5'-GTP trisodium salt hydrate	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Exosomes Endogenous Metabolite DNA/RNA Synthesis
Guanosine 5'-triphosphate (5'-GTP) trisodium salt hydrate is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt hydrate can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt hydrate holds promise for research in biosynthesis and skeletal muscle regeneration .

HY-113226

Orotidine 1 Publications Verification	Natural Products Microorganisms Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Orotidine, a nucleotide, is an intermediate in pyrimidine nucleotide biosynthesis in RNA and DNA. Orotidine is mainly found in bacteria, fungi and plants .

HY-113138

3-Methyluridine 1 Publications Verification N3-Methyluridine	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
3-Methyluridine (m ³U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance .

HY-113225

Guanosine triphosphate GTP	Infection Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite DNA/RNA Synthesis Apoptosis Mitosis
Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-135780A

3'-Deoxyuridine-5'-triphosphate trisodium 3'-dUTP trisodium	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite
3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into *RNA* with a K_i value of 2.0 μM .

HY-N0157R

Orotic acid (Standard) 6-Carboxyuracil (Standard); Vitamin B13 (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Reference Standards Nucleoside Antimetabolite/Analog Endogenous Metabolite
Orotic acid (Standard) is the analytical standard of Orotic acid. This product is intended for research and analytical applications. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats .

HY-129963

3'-UMP disodium	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite DNA/RNA Synthesis
3'-UMP disodium is a nucleotide, that is a component of ribonucleic acid (RNA) and would be converted to uracil in rat jejunum .

HY-N0157A

Orotic acid zinc 3 Publications Verification 6-Carboxyuracil zinc; Vitamin B13 zinc	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Nucleoside Antimetabolite/Analog Endogenous Metabolite
Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats .

HY-135780

3'-Deoxyuridine-5'-triphosphate 3'-dUTP	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into *RNA* with a K_i value of 2.0 μM .

HY-W009162R

Cytidine 5'-monophosphate (Standard) 5'-Cytidylic acid (Standard); 5'-CMP (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Cytidine 5'-monophosphate (Standard) is the analytical standard of Cytidine 5'-monophosphate. This product is intended for research and analytical applications. Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group .

HY-N0157AR

Orotic acid zinc (Standard) 6-Carboxyuracil zinc (Standard); Vitamin B13 zinc (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog Endogenous Metabolite Reference Standards
Orotic acid (zinc) (Standard) is the analytical standard of Orotic acid (zinc). This product is intended for research and analytical applications. Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats .

HY-113138R

3-Methyluridine (Standard) N3-Methyluridine (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
3-Methyluridine (Standard) is the analytical standard of 3-Methyluridine. This product is intended for research and analytical applications. 3-Methyluridine (m3U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance .

Cat. No.	Product Name	Chemical Structure

HY-113225S2

Guanosine triphosphate-13C dilithium

Guanosine triphosphate- ¹³C (GTP- ¹³C) dilithium is ¹³C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113225S3

Guanosine triphosphate-15N5 dilithium

Guanosine triphosphate- ¹⁵N₅ (GTP- ¹⁵N₅) dilithium is ¹⁵N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate dilithium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate dilithium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate dilithium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate dilithium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate dilithium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113225S5

Guanosine triphosphate-13C10 dilithium

Guanosine triphosphate- ¹³C₁₀ (GTP- ¹³C₁₀) dilithium is ¹³C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate dilithium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate dilithium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate dilithium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate dilithium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate dilithium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-W009162S5

Cytidine 5′-monophosphate-13C9,15N3 dilithium

Cytidine 5′-monophosphate- ¹³C₉, ¹⁵N₃ (5'-Cytidylic acid- ¹³C₉, ¹⁵N₃ dilithium; 5'-CMP- ¹³C₉, ¹⁵N₃) dilithium is ¹³C and ¹⁵N-labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.

HY-N0157S1

Orotic acid-13C,15N2 monohydrate

Orotic acid- ¹³C, ¹⁵N₂ (monohydrate) is the ¹³C and ¹⁵N labeled Orotic acid . Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats .

HY-113225S1

Guanosine triphosphate-13C10,15N5 tetraammonium solution (100 mM)

Guanosine triphosphate- ¹³C₁₀, ¹⁵N₅ tetraammonium is the ¹³C and ¹⁵N labeled Guanosine triphosphate tetraammonium. Guanosine triphosphate tetraammonium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate tetraammonium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate tetraammonium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate tetraammonium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate tetraammonium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113225S4

Guanosine triphosphate-15N5,d14 dilithium

Guanosine triphosphate- ¹⁵N₅,d₁₄ (GTP- ¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate dilithium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate dilithium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate dilithium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate dilithium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate dilithium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-W009162S

Cytidine 5′-monophosphate-15N3 disodium
Cytidine 5′-monophosphate- ¹⁵N₃ (disodium) is the ¹⁵N labeled Cytidine 5'-monophosphate disodium . Cytidine 5'-monophosphate (5'-Cytidylic acid) disodium is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate disodium consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group .

HY-W009162S2

Cytidine 5′-monophosphate-d12 dilithium
Cytidine 5′-monophosphate-d₁₂ (5'-Cytidylic acid-d₁₂ dilithium; 5'-CMP-d₁₂) dilithium is deuterium labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.

HY-W009162S4

Cytidine 5′-monophosphate-15N3 dilithium
Cytidine 5′-monophosphate- ¹⁵N₃ (5'-Cytidylic acid- ¹⁵N₃ dilithium; 5'-CMP- ¹⁵N₃) dilithium is ¹⁵N labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.

HY-W009162S1

Cytidine 5′-monophosphate-13C9 dilithium
Cytidine 5′-monophosphate- ¹³C₉ (5'-Cytidylic acid- ¹³C₉ dilithium; 5'-CMP- ¹³C₉) dilithium is ¹³C-labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.

HY-W009162S3

Cytidine 5′-monophosphate-15N3,d12 dilithium

Cytidine 5′-monophosphate- ¹⁵N₃,d₁₂ (5'-Cytidylic acid- ¹⁵N₃,d₁₂ dilithium; 5'-CMP- ¹⁵N₃,d₁₂) dilithium is deuterium and ¹⁵N labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.

Cat. No.	Product Name		Classification

HY-134320

8-Azido-ATP 8-Azidoadenosine 5'-triphosphate; 8-N3-ATP		Azide
8-Azido-ATP, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase . 8-Azido-ATP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-134320A

8-Azido-ATP tetrasodium 8-Azidoadenosine 5'-triphosphate tetrasodium; 8-N3-ATP tetrasodium		Azide
8-Azido-ATP (8-Azidoadenosine 5'-triphosphate) tetrasodium, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase. 8-Azido-ATP tetrasodium is a click chemistry reagent that contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. 8-Azido-ATP tetrasodium can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

Cat. No.	Product Name		Classification

HY-W010737

Guanosine-5'-triphosphate disodium salt Maximum Cited Publications 8 Publications Verification 5'-GTP disodium salt		Nucleotide Analogs
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

HY-12695

Guanosine 5'-triphosphate trisodium 5 Publications Verification 5'-GTP trisodium		Nucleotide Analogs
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate trisodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

HY-W009162

Cytidine 5'-monophosphate 1 Publications Verification 5'-Cytidylic acid; 5'-CMP		Nucleotide Analogs
Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group .

HY-W009444

5-Methyluridine 1 Publications Verification		Nucleoside Analogs Uridine
5-Methyluridine (m ⁵U) is an RNA modified nucleotide generated by RNA methyltransferases (such as TrmA and RumA), which mainly targets specific uracil sites in RNA molecules such as the T arm of tRNA and rRNA. 5-Methyluridine relies on enzyme recognition of RNA secondary/tertiary structures (such as the T loop of tRNA or the specific stem-loop structure of rRNA) and participates in physiological processes such as translation accuracy and ribosome function by stabilizing RNA folding or regulating base pairing .

HY-12695B

Guanosine 5'-triphosphate trisodium salt hydrate Maximum Cited Publications 8 Publications Verification 5'-GTP trisodium salt hydrate		Nucleotide Analogs
Guanosine 5'-triphosphate (5'-GTP) trisodium salt hydrate is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt hydrate can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt hydrate holds promise for research in biosynthesis and skeletal muscle regeneration .

HY-153845

RNA Aptamer Broccoli sodium		Aptamers
RNA Aptamer Broccoli sodium is a 49-nucleotide nucleic acid aptamer that is much shorter than Spinach and Spinach2. It exhibits bright green fluorescence when binding to DFHBI or DFHBI-1T (a soluble analog of the green fluorescent protein label). RNA Aptamer Broccoli sodium can be used for RNA expression or localization in living cells .

HY-W011548

2-Aminoadenosine		Nucleoside Analogs Adenosine
2-Aminoadenosine is a modified adenine base and adenosine analog that stabilizes RNA duplexes and enhances template-directed nucleotide condensation reactions. 2-Aminoadenosine forms three hydrogen bonds with uracil to increase the melting temperature of hybrid strands, thereby stabilizing uracil-containing RNA duplexes .

HY-148100

Emapticap pegol 1 Publications Verification NOX-E36		Aptamers
Emapticap pegol (NOX-E36) is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36). mNOX-E36 is a murine-specific analogue of NOX-E36, an anti-MCP-1 L-RNA aptamer that was previously shown to attenuate liver fibrosis in mice .

HY-113225

Guanosine triphosphate GTP		Nucleotide Analogs
Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-148688

ASO 556089 sodium		Antisense Oligonucleotides
ASO 556089 sodium is a 16 nucleotide length gapmer (3-10-3) that targets the human and mouse long non-coding RNA MALAT1, with the sequence: 5’-GmCATTmCTAATAGmCAGmC-3’ .

HY-148100A

Emapticap pegol sodium 1 Publications Verification NOX-E36 sodium		Aptamers
Emapticap pegol sodium is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol sodium is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) .

HY-154909A

6-Azauridine triphosphate ammonium 1 Publications Verification 6-Azauridine 5′-triphosphate ammonium		Nucleotide Analogs
6-Azauridine triphosphate ammonium (6-Azauridine 5′-triphosphate ammonium) is a nucleotide analog similar to uridine triphosphate, which can be used to study the mechanism of RNA synthesis and transcription regulation .

HY-160231

ssRNA42 sodium		CpG ODNs
ssRNA42 (sodium) is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. ssRNA42 (sodium) derives from ssRNA40 by replacement of all G nucleotides with adenosine. ssRNA42 activated human PBMCs to secrete IFN-α, TNF-a, IL- 12p40, and IL-6, but ssRNA42 failed to stimulated murine pDCs and PBMCs.

HY-W042357

Ac-rC Phosphoramidite		Phosphoramidites Cytosine
Ac-rC Phosphoramidite is a cytosine phosphoramidite used in the chemical synthesis of RNA oligonucleotides. Ac-rC Phosphoramidite enables the incorporation of cytidine nucleotides into synthetic RNA strands, and its unique protecting groups ensure the structural integrity of the molecule throughout complex synthetic processes .

HY-153846

RNA Aptamer Mango I sodium		Aptamers
RNA Aptamer Mango Ⅰ (sodium) consists of 39 nucleotides and has an exceptionally high affinity to TO1-biotin (a thiazole orange derivative fluorophore). RNA Aptamer Mango Ⅰ (sodium) can be used to visualize RNA expression or localization in live cells.

HY-154909

6-Azauridine triphosphate 6-Azauridine 5′-triphosphate		Nucleotide Analogs
6-Azauridine triphosphate (6-Azauridine 5′-triphosphate) is a nucleotide analog similar to uridine triphosphate, which can be used to study the mechanism of RNA synthesis and transcription regulation .

HY-157091

Uridine, 5'-P,P',P'',P''-tetrahydrogen imidotriphosphate		Nucleotide Analogs Uracil Nucleotide
Uridine, 5'-(P,P',P'',P''-tetrahydrogen imidotriphosphate) is a non-hydrolyzable nucleotide that can synthesize RNA oligonucleotides .

HY-160693

2′-O-Methylguanosine 5′-monophosphate		Nucleotide Analogs Guanine Nucleotide
2′-O-Methylguanosine 5′-monophosphate is the nucleotide complex group (pGm) of the ribosome and is primarily used for DNA conjugation. Today's antibodies recognize pGm, in descending order of importance, as the parent base, the methylated ribose moiety, and the phosphate group. 2′-O-Methylguanosine 5′-monophosphate can also be used to prepare RNA vaccines as a 5′-terminal nucleotide to block the RNA molecule .

HY-160745

2'-O-methyladenosine 5'-phosphate		Nucleotide Analogs Adenine Nucleotide
2'-O-methyladenosine 5'-phosphate is the nucleotide complex group of ribosomes and is mainly used for DNA conjugation. 2'-O-methyladenosine 5'-phosphate is used to prepare RNA vaccines and is the main part of the RNA molecule, while the 5'-end is blocked by 2'-O-Methylguanosine 5'-monophosphate .

HY-177582

N1-Methyl-GTP		Nucleotide Analogs
N1-Methyl-GTP is a nucleotide analog of GTP. N1-Methyl-GTP shows a half-maximal inhibitory concentration of 8.1 μM and an inhibition constant of 1.5 μM against yeast RTPase. N1-Methyl-GTP can be used as a probe molecule to explore the structural flexibility of the active site of RNA triphosphatase and the mechanism of substrate recognition .

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RNA nucleotides

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