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Sedoheptulose

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By Targets:	AP-1 (1) Bacterial (1) Biochemical Assay Reagents (2) COX (1) Drug Intermediate (1) Endogenous Metabolite (5) Fructose-1,6-bisphosphate aldolase (1) Interleukin Related (1) JNK (1) NADPH Oxidase (1) NF-κB (1) NO Synthase (1) Reactive Oxygen Species (ROS) (1) TGF-β Receptor (1) TNF Receptor (1)
By Research Areas:	Infection (1) Metabolic Disease (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113206

*D-Sedoheptulose* 7-phosphate**	Endogenous Metabolite	Metabolic Disease
D-Sedoheptulose 7-phosphate is a common precursor for the heptoses of septacidin (group III) and hygromycin B (group IV). D-Sedoheptulose 7-phosphate can be converted to NDP-heptoses through similar biosynthetic pathways in those compounds .

HY-113206A

*D-Sedoheptulose-7-phosphate barium* 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
D-Sedoheptulose-7-phosphate barium is a common precursor for the heptoses of septacidin (group III) and hygromycin B (group IV). D-Sedoheptulose-7-phosphate barium can be converted to NDP-heptoses through similar biosynthetic pathways in those compounds .

HY-W145500

Sedoheptulose anhydride Sedoheptulosan	Biochemical Assay Reagents	Others
Sedoheptulose anhydride is a compound belonging to the class of carbohydrates. It is a derivative of sedoheptulose, a seven-carbon sugar. Sedoheptulose anhydride is commonly used in biochemistry as a precursor for various metabolic pathways. It can be converted into Sedoheptulose 1,7-bisphosphate, which is an important molecule for photosynthesis and carbon fixation. In addition to its use in biochemistry, Sedoheptulose anhydride has applications in cancer research.

HY-N16527

7-O-Galloyl-D-sedoheptulose	TNF Receptor Interleukin Related NADPH Oxidase Reactive Oxygen Species (ROS) NF-κB COX NO Synthase JNK AP-1 TGF-β Receptor	Metabolic Disease
7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound. 7-O-Galloyl-D-sedoheptulose lowers the serum levels of glucose, leptin, insulin, C-peptide, resistin, TNF-α, IL-6, and increases the serum level of adiponectin. 7-O-Galloyl-D-sedoheptulose significantly reduces the levels of ROS and lipid peroxidation products (TBARS) by down-regulating the protein expression of NADPH oxidase subunit Nox-4 and p22phox. 7-O-Galloyl-D-sedoheptulose down-regulates NF-κB and related pro-inflammatory factors (COX-2, iNOS), inhibits the phosphorylation of JNK and the activity of its downstream AP-1. 7-O-Galloyl-D-sedoheptulose reduces the expression of TGF-β1 and fibronectin, indicating its potential in anti-tissue fibrosis. 7-O-Galloyl-D-sedoheptulose can be used for the study of type 2 diabetes and its hepatic and pancreatic complications .

HY-W726070

*Sedoheptulose*	Drug Intermediate Endogenous Metabolite	Others
Sedoheptulose is a heptulose. Sedoheptulose, in the form of phosphate esters, functions as a metabolic intermediate in the pentose phosphate pathway. Sedoheptulose serves as a starting material for the chemical synthesis of pseudoaminosugars and chiral substituted furans .

HY-131575

Sedoheptulose 1,7-diphosphate	Biochemical Assay Reagents	Others
Sedoheptulose 1,7-diphosphate is a substrate for fructose bisphosphatase form B from Synechococcus leopoliensis. Sedoheptulose 1,7-diphosphate undergoes hydrolysis at the carbon 1-ester, stabilizes the activated tetrameric state of fructose bisphosphatase form B, and prevents the enzyme’s slow inactivation. Sedoheptulose 1,7-diphosphate supports fructose bisphosphatase form B-mediated bisphosphatase reactions within the reductive pentose phosphate cycle .

HY-N17111

1,7-Di-O-Galloyl-D-sedoheptulose	Others	Others
1,7-Di-O-Galloyl-D-sedoheptulose is a phenolic acid that can be found in pomegranate arils .

HY-E71021

Transaldolase, Baker's yeast (S. cerevisiae)	Endogenous Metabolite	Metabolic Disease
Transaldolase, Baker's yeast (S. cerevisiae) (EC 2.2.1.2) is an enzyme of the non-oxidative phase of the pentose phosphate pathway. The following chemical reaction is catalyzed by transaldolase:sedoheptulose 7-phosphate + glyceraldehyde 3-phosphate? erythrose 4-phosphate + fructose 6-phosphate.

HY-N11733

D-Glucoheptose	Bacterial	Infection
D-Glucoheptose is a heptose monosaccharide that serves as a starting material for sedoheptulose. D-Glucoheptose has a strong association with the genus Symbiobacterium. The content of D-Glucoheptose in urine of the control group without liver injury is higher than that in the anti-tuberculosis drug-induced liver injury group. D-Glucoheptose can be used in studies related to anti-tuberculosis drug-induced liver injury .

HY-P2726A

Aldolase, Spinach	Endogenous Metabolite Fructose-1,6-bisphosphate aldolase	Metabolic Disease
Aldolase, Spinach (EC 4.1.2.13) is an enzyme catalyzing a reversible reaction that splits the aldol, fructose 1,6-bisphosphate, into the triose phosphates dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (G3P). Aldolase, Spinach (EC 4.1.2.13) can also produce DHAP from other (3S,4R)-ketose 1-phosphates such as fructose 1-phosphate and sedoheptulose 1,7-bisphosphate.

Cat. No.	Product Name	Type

HY-W145500

Sedoheptulose anhydride Sedoheptulosan	Biochemical Assay Reagents
Sedoheptulose anhydride is a compound belonging to the class of carbohydrates. It is a derivative of sedoheptulose, a seven-carbon sugar. Sedoheptulose anhydride is commonly used in biochemistry as a precursor for various metabolic pathways. It can be converted into Sedoheptulose 1,7-bisphosphate, which is an important molecule for photosynthesis and carbon fixation. In addition to its use in biochemistry, Sedoheptulose anhydride has applications in cancer research.

Sedoheptulose anhydride

Sedoheptulosan

Biochemical Assay Reagents

Sedoheptulose anhydride is a compound belonging to the class of carbohydrates. It is a derivative of sedoheptulose, a seven-carbon sugar. Sedoheptulose anhydride is commonly used in biochemistry as a precursor for various metabolic pathways. It can be converted into Sedoheptulose 1,7-bisphosphate, which is an important molecule for photosynthesis and carbon fixation. In addition to its use in biochemistry, Sedoheptulose anhydride has applications in cancer research.

*D-Sedoheptulose* 7-phosphate**	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
D-Sedoheptulose 7-phosphate is a common precursor for the heptoses of septacidin (group III) and hygromycin B (group IV). D-Sedoheptulose 7-phosphate can be converted to NDP-heptoses through similar biosynthetic pathways in those compounds .

7-O-Galloyl-D-sedoheptulose	Structural Classification Cornaceae Cornus officinalis Sieb. et Zucc. Phenols Polyphenols Plants Source Classification	TNF Receptor Interleukin Related NADPH Oxidase Reactive Oxygen Species (ROS) NF-κB COX NO Synthase JNK AP-1 TGF-β Receptor
7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound. 7-O-Galloyl-D-sedoheptulose lowers the serum levels of glucose, leptin, insulin, C-peptide, resistin, TNF-α, IL-6, and increases the serum level of adiponectin. 7-O-Galloyl-D-sedoheptulose significantly reduces the levels of ROS and lipid peroxidation products (TBARS) by down-regulating the protein expression of NADPH oxidase subunit Nox-4 and p22phox. 7-O-Galloyl-D-sedoheptulose down-regulates NF-κB and related pro-inflammatory factors (COX-2, iNOS), inhibits the phosphorylation of JNK and the activity of its downstream AP-1. 7-O-Galloyl-D-sedoheptulose reduces the expression of TGF-β1 and fibronectin, indicating its potential in anti-tissue fibrosis. 7-O-Galloyl-D-sedoheptulose can be used for the study of type 2 diabetes and its hepatic and pancreatic complications .

*Sedoheptulose*	Structural Classification Natural Products Microorganisms Source Classification	Drug Intermediate Endogenous Metabolite
Sedoheptulose is a heptulose. Sedoheptulose, in the form of phosphate esters, functions as a metabolic intermediate in the pentose phosphate pathway. Sedoheptulose serves as a starting material for the chemical synthesis of pseudoaminosugars and chiral substituted furans .

Sedoheptulose 1,7-diphosphate	Structural Classification Natural Products Microorganisms Endogenous metabolite Source Classification	Biochemical Assay Reagents
Sedoheptulose 1,7-diphosphate is a substrate for fructose bisphosphatase form B from Synechococcus leopoliensis. Sedoheptulose 1,7-diphosphate undergoes hydrolysis at the carbon 1-ester, stabilizes the activated tetrameric state of fructose bisphosphatase form B, and prevents the enzyme’s slow inactivation. Sedoheptulose 1,7-diphosphate supports fructose bisphosphatase form B-mediated bisphosphatase reactions within the reductive pentose phosphate cycle .

1,7-Di-O-Galloyl-D-sedoheptulose	Structural Classification Euphorbia ingens E. Mey. ex Boiss. Phenols Polyphenols Plants Fagaceae Source Classification	Others
1,7-Di-O-Galloyl-D-sedoheptulose is a phenolic acid that can be found in pomegranate arils .

D-Glucoheptose	Structural Classification Vitis vinifera cv. Zalema Plants Vitaceae Saccharides Monosaccharides Source Classification	Bacterial
D-Glucoheptose is a heptose monosaccharide that serves as a starting material for sedoheptulose. D-Glucoheptose has a strong association with the genus Symbiobacterium. The content of D-Glucoheptose in urine of the control group without liver injury is higher than that in the anti-tuberculosis drug-induced liver injury group. D-Glucoheptose can be used in studies related to anti-tuberculosis drug-induced liver injury .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Sedoheptulose

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Natural
Products