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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
T. b. brucei
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "T. b. brucei" in MCE Product Catalog:
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Acoziborole (SCYX-7158) is an effective, safe and orally active antiprotozoal agent for the research of human african trypanosomiasis (HAT). In the T. b. brucei S427 strain, the MIC value for SCYX-7158 is 0.6 μg/mL .
Cat. No.: HY-W043676
CAS No.: 1210-34-0
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Dibenzosuberol (Compound 2) is a key intermediate in the synthesis of compounds associated with inhibiting Trypanosoma thiol reductase (TryR). Dibenzosuberol also shows inhibition of T. brucei with an EC50 value of 51.3 μM. Dibenzosuberol is also an impurity of Amitriptyline (HY-B0527) .
Cat. No.: HY-155531
CAS No.: 3052256-03-5
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PEX5-PEX14 PPI-IN-2 (compound 12) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor. PEX5-PEX14 PPI-IN-2 inhibits PEX14-PEX5 PPI with EC50 values of 5 and 17 µM in T. b. brucei and HepG2 cells, respectively. PEX5-PEX14 PPI-IN-2 can be used in the research of diseases related to trypanosome infection .
Cat. No.: HY-179690
CAS No.: 671754-20-4
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Antiparasitic agent-30 is a potent adenosine kinase TbrAK modulator and antitrypanosomal agent. Antiparasitic agent-30 exhibits significant inhibitory activity against Trypanosoma brucei rhodesiense, while enhancing the activity of recombinant TbrAK(EC50=38 nM, Ka=75 nM-497 nM). Antiparasitic agent-30 exerts its pharmacological effects by eliminating intrinsic substrate inhibition and hyperactivating TbrAK in Trypanosoma brucei rhodesiense. Antiparasitic agent-30 serves as a valuable tool molecule for studying acute African human trypanosomiasis (sleeping sickness) .
Cat. No.: HY-155732
CAS No.: 3032452-65-3
NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC500 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC50 values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19, respectively .
Cat. No.: HY-Q40175
CAS No.: 438474-67-0
Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research .
Cat. No.: HY-155530
CAS No.: 3052256-26-2
PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 PPI inhibitor. PEX5-PEX14 PPI-IN-1 disrupts the PEX5-TbPEX14 PPI with a Ki of 53 μM. PEX5-PEX14 PPI-IN-1 inhibits the bloodstream form of T. b. brucei (EC50: 5 μM) .
Cat. No.: HY-111906
CAS No.: 1222509-12-7
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SCYX-6759 is an orally active, blood-brain barrier permeable anti-T. brucei agent. SCYX-6759 inhibits cytochrome P450 (IC50s: 30.3, 30.6, 47.4 μM for 2D6, 2C9, 2C19, respectively.) SCYX-6759 exhibits potent activity against T. b. brucei 427, T. b. rhodesiense STIB900, and T. b. gambiense STIB930, with IC50s of 0.07, 0.038 and 0.030 μg/mL, respectively .
Cat. No.: HY-163003
Antitrypanosomal agent 19 (compound 10) is an orally available antitrypanosomal agent. Antitrypanosomal agent 19 effectively inhibits the growth of trypanosomatids T. b. brucei, T. b. gambiense and T. b. rhodesiense, mitigating the Human trypanosomiasis (HAT)-induced acute infectious toxicity in mice .
Cat. No.: HY-N11550
CAS No.: 158994-32-2
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Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC50 of 0.01 μg/mL. Megazol can be used for the research of protozoan infections .
Cat. No.: HY-151195
CAS No.: 2827061-47-0
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20S Proteasome-IN-4 (Compound 7) is a brain-penetrant, parasite-selective, orally active 20S proteasome inhibitor with an IC50 of 6.3 nM against T. b. brucei 20S proteasome. 20S Proteasome-IN-4 can be used for the research of human African trypanosomiasis (HAT) .
Cat. No.: HY-136200
CAS No.: 475626-30-3
Antitrypanosomal agent 2 is a potent and selective trypanosoma brucei inhibitor .
Cat. No.: HY-170363
CAS No.: 3063720-23-7
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Proteasome-IN-6 (Compound J-80) inhibits the β5 catalytic subunit of the Trypanosoma brucei 20S proteasome, inibits T. b. brucei, T. b. gambiense and T. b. rhodesiense with EC50s of 157 nM, 220 nM and 156 nM, respectively. Proteasome-IN-6 exhibits antitrypanosomal activity in mouse model .
Cat. No.: HY-146049
CAS No.: 2456427-48-6
Antitrypanosomal agent 4 (compound 19) is a potent and blood-brain barrier permeable antitrypanosomal agent. Antitrypanosomal agent 4 has good activity against Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei brucei (T. b. brucei) with IC50s of 1.2 μM and 70 nM, respectively . Antitrypanosomal agent 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-116045
CAS No.: 1622300-88-2
PDEB1-IN-1 (Compound 12b) is the derivative of Cilomilast (HY-10790), and serves as an inhibitor for TryPanosoma Brucei PDEB1 (TbrPDEB1) with an IC50 of 0.95 μM. PDEB1-IN-1 inhibits the proliferation of T. Brucei with an EC50 of 26 μM .
Cat. No.: HY-145812
CAS No.: 1990479-14-5
CRK12-IN-1 is a potent CRK12 inhibitor. CRK12-IN-1 is extremely potent against T.b. brucei and rapidly cytocidal, as well as equally potent against T. congolense and T. vivax (EC50 of 1.3 and 18 nM, respectively) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
