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Thiamine metabolism

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (1) Endogenous Metabolite (3) Transketolase (1)
By Research Areas:	Metabolic Disease (2) Neurological Disease (2)

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Targets Recommended: Mitochondrial Metabolism

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122273

Pyrithiamine hydrobromide	Drug Derivative	Neurological Disease
Pyrithiamine hydrobromide is a thiamine metabolic inhibitor that can act as a substrate for thiamine pyrophosphokinase. Pyrithiamine hydrobromide can be used in the research of nervous system diseases .

HY-W587827

Thiamine triphosphoric acid ester Thiamine triphosphate	Endogenous Metabolite	Metabolic Disease
Thiamine triphosphoric acid ester (Thiamine triphosphate) is a neuroactive compound and a triphosphate derivative of vitamin thiamine. Thiamine triphosphoric acid ester exists in microorganisms, animal organs and plants. In E. coli, Thiamine triphosphoric acid ester is transiently produced under amino acid deficiency, while in mammalian cells, it is continuously produced at a low rate. Thiamine triphosphoric acid ester can be synthesized by two distinct enzymes (cytosolic AK1 and FoF1-ATP synthase in brain mitochondria). Thiamine triphosphoric acid ester plays a fundamental role in cellular metabolism or cellular signal transduction .

HY-128606

Thiamine diphosphate analog 1	Endogenous Metabolite Transketolase	Neurological Disease Metabolic Disease
Thiamine diphosphate analog 1 is an analog of thiamine diphosphate. Thiamine diphosphate is the active metabolite of vitamin B₁ in organisms. Thiamine diphosphate targets ThDP-dependent enzymes such as transketolase and pyruvate dehydrogenase complex, acting as an essential coenzyme to exert an activating effect. Thiamine diphosphate assists in catalytic reactions in free form and initiates the catalytic cycles of various glucose-metabolizing enzymes. Thiamine diphosphate serves as a diagnostic biomarker and protective factor for Alzheimer's disease. Thiamine diphosphate can be used in research related to metabolism and Alzheimer's disease .

HY-P2891A

Pyruvate oxidase, Aerococcus viridans PoxB, Aerococcus viridans	Endogenous Metabolite	Others
Pyruvate oxidase, Aerococcus viridans (PoxB) is a thiamine pyrophosphate-dependent oxidase that catalyzes the oxidative decarboxylation of pyruvate to produce acetyl phosphate, carbon dioxide, and water. Pyruvate oxidase, Aerococcus viridans is an important enzyme in bacterial metabolism and can enhance ATP production. Additionally, Pyruvate oxidase, Aerococcus viridans can be used for the determination of aspartate aminotransferase and alanine aminotransferase activities .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122273

Pyrithiamine hydrobromide	Microorganisms Source Classification	Drug Derivative
Pyrithiamine hydrobromide is a thiamine metabolic inhibitor that can act as a substrate for thiamine pyrophosphokinase. Pyrithiamine hydrobromide can be used in the research of nervous system diseases .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Thiamine metabolism

Inhibitors & Agonists

NaturalProducts

Natural
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