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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
Triphenylphosphonium
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "Triphenylphosphonium" in MCE Product Catalog:
6
6 Cited Publications
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AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H2S) donor. AP39 increases intracellular H2S levels. AP39 exerts cytoprotective effects and maintains mitochondrial DNA integrity under oxidative stress conditions. AP39 protects against myocardial reperfusion injury in mice model and has the potential for Alzheimer's disease research .
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3 Cited Publications
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Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP + cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function .
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SMTIN-T140 (compound 6a) is a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor, with an IC50 of 1.646 μM. SMTIN-T140 shows anticancer activity. SMTIN-T140 leads to mitochondrial dysfunction, increases mitochondrial ROS production and activates AMPK. SMTIN-T140 potently suppressed tumor growth without any noticeable in vivo toxicity in a mouse model xenografted with PC3 prostate cancer cells .
Cat. No.: HY-I0607A
CAS No.: 30018-16-7
Cat. No.: HY-P10563
CAS No.: 2580150-96-3
Synonyms: BHV-1100
Cat. No.: HY-P3350
CAS No.: 2892148-58-0
Cat. No.: HY-N15837
CAS No.: 2936622-20-5
DSPE-PEG(2000)-N-Triphenylphosphonium is functionalized PEG lipid that can be used to synthesize lipid nanoparticles for drug delivery.
Cat. No.: HY-173549
Synonyms: CPPA-Triphenylphosphonium
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CPPA-TPP (CPPA-Triphenylphosphonium) is a compound conjugated to the mitochondria-targeting moiety triphenylphosphonium (TPP). CPPA-TPP can be used in the synthesis of nanoparticles that release Camptothecin (HY-16560) in a reactive oxygen species dependent manner, leading to cancer cell death .
Cat. No.: HY-186012
CAS No.: 3032193-08-8
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TPP@CUR is the product formed by the esterification reaction between Curcumin (HY-N0005) and (5-hydroxy-5-oxopentyl)triphenylphosphonium bromide (TPP). TPP@CUR can be used to synthesize Ser@TPP@CUR (HY-151342), which can then be used in studies of acute kidney injury .
Cat. No.: HY-W010882S
CAS No.: 42932-63-8
Cat. No.: HY-105168
CAS No.: 157380-72-8
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Cat. No.: HY-N16300
CAS No.: 3091879-75-0
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Mito-laurdan (bromide) is a Fluorescent dye for mitochondrial membrane fluidity and packing measurement. It depends on membrane potential for targeting: it contains a cationic triphenylphosphonium moiety that accumulates at the inner mitochondrial membrane due to the membrane's negative potential, connected via a 3-carbon linker. As a solvatochromic dye derived from Laurdan (HY-D0080), it retains the characteristic mechanism where fluorescence emission shifts based on membrane packing: in more fluid, loosely packed membranes, greater water penetration leads to increased dipolar relaxation and a bathochromic red shift in emission, while more ordered membranes show a blue-shifted emission; these shifts are quantified using generalized polarization, calculated from emission intensities in ordered and disordered spectral windows. Its excitation wavelength is 352 nm, with emission detected in ordered (409-463 nm) and disordered (473-516 nm) spectral windows. It localizes specifically to mitochondria in HeLa cells, showing high signal overlap with MitoTracker Deep Red, and can detect changes in inner mitochondrial membrane fluidity .
Synonyms: Phosphonium, methyltriphenyl-, bromide (8CI,9CI)-d3; M 0779-d3; MTPPB-d3; Phosphonium,methyltriphenyl-,bromide-d3; MethylTriphenylphosphonium bromide-d3
Cat. No.: HY-158918
CAS No.: 2661108-93-4
Synonyms: 4-CF3-Triphenylphosphonium-DC
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4-CF3-TPP-DC (4-CF3-Triphenylphosphonium-DC) is an inert mitochondrial targeting carrier, that delivers target drugs and probes to mitochondria without causing mitochondrial depolarization and cytotoxicity in cell C2C12 .
Cat. No.: HY-187140
CAS No.: 52956-93-1
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(7-Carboxyheptyl) triphenylphosphonium bromide (Compound 15) is a triphenylphosphonium cationic carboxylic acid and serves as a synthetic precursor for the preparation of mitochondria-targeted antibiotic conjugates .
Cat. No.: HY-129303
CAS No.: 779282-36-9
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AP39 (Item No. 17100) is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H2S-releasing portion.
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Mito-apocynin (C2), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP + cation. Mito-apocynin (C2) exhibits antineuroinflammatory effect .
Cat. No.: HY-176775
CAS No.: 1423018-61-4
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TPP-IOA is a cytochrome c peroxidase inhibitor. TPP-IOA inhibits apoptosis by preventing cardiolipin oxidation and cytochrome c release to the cytosol. TPP-IOA disrupts oxidative phosphorylation in isolated mitochondria. TPP-IOA inhibits cell death in SH-SY5Y cells grown in glucose, but not galactose. TPP-IOA causes mitochondrial depolarization and network fragmentation. TPP-lOA mitigates radiation induced death in mice .
Cat. No.: HY-149067
CAS No.: 2719867-46-4
Antifungal agent 47 (compound 3b) shows the highest and broad-spectrum fungicidal activity, strong respiratory inhibition activity, and adenosine 5′-triphosphate synthesis inhibition activity. Antifungal agent 47 is potential as a fungicide .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
