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Cat. No.: HY-173549

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CPPA-TPP

Name: CPPA-TPP
Brand: MedChemExpress
SKU: HY-173549
Availability: PreOrder

(Synonyms: CPPA-Triphenylphosphonium)

CPPA-TPP (CPPA-Triphenylphosphonium) is a compound conjugated to the mitochondria-targeting moiety triphenylphosphonium (TPP). CPPA-TPP can be used in the synthesis of nanoparticles that release Camptothecin (HY-16560) in a reactive oxygen species dependent manner, leading to cancer cell death.

For research use only. We do not sell to patients.

Formula: C₃₃H₃₁BrNO₂PS₂
Molecular Weight:648.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CPPA-TPP Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

Molecular Weight 648.61
Formula C₃₃H₃₁BrNO₂PS₂
SMILES

O=C(OCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)CCC(C)(SC(C4=CC=CC=C4)=S)C#N.[Br-]
Synonyms

CPPA-Triphenylphosphonium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang W, et al. Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy. Nat Commun. 2019 Apr 12;10(1):1704. doi: 10.1038/s41467-019-09566-3. Erratum in: Nat Commun. 2019 Jun 10;10(1):2597. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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