2 Results for "

Tumor-to-kidney ratio

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Tumor-to-kidney ratio" in MCE Product Catalog:

Cat. No.: HY-W1126504
CAS No.: 3066864-32-9
Synonyms: MC339
Target:  

Notch

Research Areas:  

Cancer

ETN029 (MC339) is a selective DLL3 ligand. ETN029 labeled with 225Ac has dose-dependent cytotoxicity in SCLC, NEPC and metastatic melanoma cells and increases the phosphorylation of H2AX expression. ETN029 labeled with 177Lu shows rapid uptake persistent tumor retention and favorable tumor-to-kidney ratio. ETN029 can be used for cancers like SCLC and NEPC imaging and research .
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Cat. No.: HY-159771
CAS No.: 3095069-75-0
Target:  

FAP

Research Areas:  

Cancer

FAP6-19 is a fibroblast activation protein (FAP) targeting radioligand with a Kd of 18.2 nM. FAP6-19 selectively delivers therapeutic radioactive nuclides (such as 177Lu) to the tumor site by targeting the overexpressed FAP protein in the tumor microenvironment, achieving precise killing of cancer cells while minimizing radiation damage to healthy tissues. FAP6-19 exhibits extremely high total cellular uptake and good intracellular retention ability in HT1080 cells. After being labeled with 111In, FAP6-19 produced extremely high tumor/kidney and tumor/liver dose ratios in the mouse model with 4T1 tumors. FAP6-19 can be used in the research of solid tumors expressing FAP.
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