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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
VSMCs
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "VSMCs" in MCE Product Catalog:
17
17 Publications Verification
Research Areas:
YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors .
17
17 Publications Verification
Research Areas:
YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors .
6
Category:
Cardiovascular Disease Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Plants Disease Research Fields Indole Alkaloids Rubiaceae Extract
Target:
3
Category:
Cardiovascular Disease Alkaloids Plants Disease Research Fields Indole Alkaloids Apocynaceae Extract Catharanthus roseus (L.) G. Don
Target:
3
3 Cited Publications
Synonyms: (+)-3,4-Didehydrocoronaridine Tartrate
Category:
Cardiovascular Disease Alkaloids Plants Disease Research Fields Cancer Indole Alkaloids Apocynaceae Extract Catharanthus roseus (L.) G. Don
Target:
Cat. No.: HY-NP013
Synonyms: Mouse ox-LDL
Synonyms: E-3174; EXP-3174
Target:
Research Areas:
Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure .
Cat. No.: HY-130576
CAS No.: 121324-31-0
Target:
Research Areas:
POVPC is an oxidized phospholipid can be found in in oxidatively modified low density lipoprotein (oxLDL). POVPC inhibits VSMC growth in high serum condition. POVPC induces apoptosis in low serum condition .
Synonyms: Ind-Cl
Target:
Research Areas:
Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inflammation in vascular smooth muscle cells (VSMCs) .
Synonyms: E-3174 d4; EXP-3174 d4
Category:
Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Plants Indole Alkaloids Rubiaceae Extract
Target:
Cat. No.: HY-P10616
CAS No.: 624735-22-4
Target:
Research Areas:
Cat. No.: HY-P10617
CAS No.: 624735-23-5
Target:
Research Areas:
Cat. No.: HY-N0252B
CAS No.: 153230-94-5
Synonyms: (+)-3,4-Didehydrocoronaridine Sulfate
Category:
Cardiovascular Disease Alkaloids Plants Disease Research Fields Indole Alkaloids Apocynaceae Extract Catharanthus roseus (L.) G. Don
Target:
Target:
Cat. No.: HY-12765R
CAS No.: 124750-92-1
Synonyms: E-3174 (Standard); EXP-3174 (Standard)
Research Areas:
Losartan Carboxylic Acid (Standard) is the analytical standard of Losartan Carboxylic Acid. This product is intended for research and analytical applications. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure [4].
Cat. No.: HY-12765S1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
