2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Stem Cell/Wnt
  3. LDLR ROR β-catenin
  4. Oxidized low density lipoprotein (mouse)

Oxidized low density lipoprotein (mouse)  (Synonyms: Mouse ox-LDL)

Cat. No.: HY-NP013 Purity: ≥98%
COA
SDS
Handling Instructions Technical Support

Oxidized low density lipoprotein (mouse) (Mouse ox-LDL) is an oxidized low density lipoprotein (LDL). Oxidized low density lipoprotein (mouse) induces atherosclerosis (AS) by facilitating endothelial dysfunction and accelerating the VSMCs growth and migration. Oxidized low density lipoprotein (mouse) can be used to construct an in vitro model of AS.

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Based on 4 publication(s) in Google Scholar

Oxidized low density lipoprotein (mouse) Related Antibodies

Top Publications Citing Use of Products
Cell Proliferation/Viability Assay
ELISA
WB
Cell Imaging/Staining
Bio/Physico-chemical Assay

    Oxidized low density lipoprotein (mouse) purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Apr 25:18:5573-5586.  [Abstract]

    THP-1-derived macrophage cells were incubated with CG (0, 1, 3, 10, 30, and 100 μM) for 24 h, prior to being stimulated with Oxidized low density lipoprotein (ox-LDL) (50 μg/mL) for 24 h. Then, the cell viability was detected using CCK-8 assay.

    Oxidized low density lipoprotein (mouse) purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Apr 25:18:5573-5586.  [Abstract]

    The effect of CG on ox-LDL-induced inflammation in THP-1-derived macrophage. THP-1-derived macrophage were incubated with CG for 24 h, prior to being stimulated with Oxidized low density lipoprotein (ox-LDL, 100 ng/mL) for 24 h. The production of inflammatory cytokines, including IL-6, IL-1β, TNF-α, and IL-10, was assayed by ELISA kits.

    Oxidized low density lipoprotein (mouse) purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Apr 25:18:5573-5586.  [Abstract]

    The effect of CG on Oxidized low density lipoprotein (ox-LDL, 100 ng/mL)-induced inflammation in THP-1-derived macrophage. THP-1-derived macrophage were incubated with CG for 24 h, The protein expressions of NLRP3, ASC, and caspase-1 were detected using Western blotting.

    Oxidized low density lipoprotein (mouse) purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Apr 25:18:5573-5586.  [Abstract]

    The effect of CG on ox-LDL-induced foam cell formation in THP-1-derived macrophages. THP-1-derived macrophages were incubated with CG for 24 h, prior to being stimulated with Oxidized low density lipoprotein (ox-LDL, 100 ng/mL) for 24 h. (A) The formation of foam cells in each group was determined using Nile red staining.

    Oxidized low density lipoprotein (mouse) purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Apr 25:18:5573-5586.  [Abstract]

    The effect of CG on ox-LDL-induced foam cell formation in THP-1-derived macrophages. THP-1-derived macrophages were incubated with CG for 24 h, prior to being stimulated with Oxidized low density lipoprotein (ox-LDL, 100 ng/mL) for 24 h. The total cholesterol (TC) and free cholesterol (FC) were detected using their corresponding commercial kits, respectively.

    Oxidized low density lipoprotein (mouse) purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Apr 25:18:5573-5586.  [Abstract]

    The effect of CG on ox-LDL-induced foam cell formation in THP-1-derived macrophages. THP-1-derived macrophages were incubated with CG for 24 h, prior to being stimulated with Oxidized low density lipoprotein (ox-LDL, 100 ng/mL) for 24 h. Cellular cholesterol efflux was measured by counting cell-associated [3H]-cholesterol using liquid scintillation counting method.

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    Description

    Oxidized low density lipoprotein (mouse) (Mouse ox-LDL) is an oxidized low density lipoprotein (LDL). Oxidized low density lipoprotein (mouse) induces atherosclerosis (AS) by facilitating endothelial dysfunction and accelerating the VSMCs growth and migration. Oxidized low density lipoprotein (mouse) can be used to construct an in vitro model of AS[1].

    In Vitro

    Oxidized low density lipoprotein (mouse) (25-75 μg/mL, 24 h) dose-dependently upregulates the mRNA and protein expressions of long noncoding RNA TUG1 and receptor tyrosine kinase-like orphan receptor 2 (ROR2); meanwhile, it promotes the proliferation of HA-VSMCs (upregulates the protein levels of CyclinD1 and Ki-67), enhances migration and invasion abilities, and increases the expressions of metastasis-related proteins β-catenin and Vimentin in human aortic vascular smooth muscle cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Oxidized low density lipoprotein (mouse) Related Antibodies
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Oxidized low density lipoprotein (mouse)]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation

    Purity: ≥98%

    SDS (394 KB)

    COA (231 KB)

    Handling Instructions (2659 KB)
    References
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    Oxidized low density lipoprotein (mouse) Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Oxidized low density lipoprotein (mouse)Mouse ox-LDLLDLRRORβ-cateninLow-density lipoprotein receptorRAR-related orphan receptorBeta cateninAtherosclerosisASox-LDLInhibitorinhibitorinhibit

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