12 Results for "

anti-CD38

" in MedChemExpress (MCE) Product Catalog:
Products (12)

12 Results for "anti-CD38" in MCE Product Catalog:

12
12 Publications Verification
Cat. No.: HY-P9915
CAS No.: 945721-28-8
Synonyms: anti-Human CD38, Human antibody; HuMax-CD38; JNJ-54767414

Target:  

CD38 ADC Antibodies

Research Areas:  

Inflammation/Immunology Cancer

Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .
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12
12 Publications Verification
Cat. No.: HY-P9915A
CAS No.: 945721-28-8
Synonyms: anti-Human CD38, Human antibody (PBS)

Target:  

ADC Antibodies CD38

Research Areas:  

Cancer

Daratumumab (PBS) (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab (PBS) has anti-multiple myeloma (MM) effect. Daratumumab (PBS) impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .
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1 Cited Publications
Cat. No.: HY-P9976A
CAS No.: 1461640-62-9

Target:  

CD38 Apoptosis

Research Areas:  

Cancer

Isatuximab (anti-CD38) is a monoclonal antibody that targets the transmembrane receptor and extracellular enzyme CD38, a protein highly expressed in hematological malignancies, including multiple myeloma. Isatuximab (anti-CD38) exhibits anti-tumor activity through multiple biological mechanisms, including antibody-dependent cell-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cell phagocytosis, and non-crosslinking direct induction of apoptosis. Isatuximab (anti-CD38) also directly inhibits the extracellular enzyme activity of CD38, which is related to many cellular functions .
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1 Cited Publications
Cat. No.: HY-P99730
CAS No.: 2227490-52-8
Synonyms: TAK-079

Target:  

CD38 Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Mezagitamab (TAK-079) is a IgG1λ anti-CD38 monoclonal antibody. Mezagitamab depletes tumor cells expressing CD38 through antibody and complement dependent cytotoxicity. Mezagitamab has potential application in relapsed/refractory multiple myeloma (RRMM) and idiopathic thrombocytopenic purpura (ITP) .
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Cat. No.: HY-P99744
CAS No.: 2254522-19-3
Synonyms: TAK-573

Target:  

CD38

Research Areas:  

Inflammation/Immunology Cancer

Modakafusp alfa (TAK-573) is a humanized, anti-CD38 IgG4 monoclonal antibody fused to 2 attenuated IFNα2b molecules, which delivers interferon-alpha to CD38-expressing cells. Modakafusp alfa has direct anti-proliferative activity on multiple myeloma (MM) cancer cells in vitro and induces robust and durable antitumor responses in MM xenograft tumor models. Modakafusp alfa in combination with anti-PD-1 antibodies induces immunomodulation and antitumor responses with good tolerance in mice .
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Cat. No.: HY-P990747
CAS No.: 2760318-99-6
Synonyms: CM-313

Target:  

CD38

Research Areas:  

Inflammation/Immunology

Lumrotatug is an anti-CD38 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-P990037
CAS No.: 2430792-01-9
Synonyms: GEN3014

Target:  

CD38

Research Areas:  

Inflammation/Immunology Cancer

Erzotabart is an IgG1-kappa, anti-CD38 (ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, cADPR1) Homo sapiens monoclonal antibody. Erzotabart shows antineoplastic activity .
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Cat. No.: HY-P991715
CAS No.: 3028478-15-8
Synonyms: SG-301

Target:  

CD38

Research Areas:  

Inflammation/Immunology

Sanritatug (SG-301) is an anti-CD38 IgG1κ antibody with potential antineoplastic activity. The corresponding isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-101780A
CAS No.: 1793059-58-1
Synonyms: EDO-S101 hydrochloride; NL-101 hydrochloride
Target:  

HDAC

Research Areas:  

Cancer

Tinostamustine hydrochloride (EDO-S101 hydrochloride) is a compound with anti-multiple myeloma activity and the ability to promote CD38 expression. Tinostamustine hydrochloride enhances the sensitivity of tumor cells to the anti-CD38 monoclonal antibody daratumumab by increasing the acetylation level of histone H3. Tinostamustine hydrochloride can increase the expression of MICA and MICB, thereby activating NK cells. Tinostamustine hydrochloride can significantly delay tumor growth and improve the survival rate of mice .
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Cat. No.: HY-P991913
Synonyms: TSK011010

Target:  

CD38

CID-103 (TSK011010) is an anti-CD38 antibody that recognizes a unique epitope on CD38. CID-103 can be used in research on immune thrombocytopenia .
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Cat. No.: HY-P991914

Target:  

CD38 Apoptosis

Research Areas:  

Cancer

FTL004 is an anti-CD38 monoclonal antibody. FTL004 exhibits enhanced Proapoptotic activity and displays stronger ADCC against CD38 + malignant cells. FTL004 can be used for the research of multiple myeloma and non-Hodgkin lymphoma[1].
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Cat. No.: HY-P992455

Research Areas:  

Cancer

SAR442085 is an Fc-engineered anti-CD38 monoclonal antibody with a Kd of 0.2 nM for human CD38. SAR442085 inhibits CD38, induces apoptosis, and triggers antibody-dependent cellular cytotoxicity and phagocytosis in CD38-expressing tumor cells. SAR442085 binds allelic variants of FcγRIIa and FcγRIIIa, enhances NK cell activation, degranulation and cytokine secretion, and exerts anti-tumor activity in human Fc receptor transgenic mice. SAR442085 can be used in the research of multiple myeloma .
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