![[Pyr1]-Apelin-13](https://file.medchemexpress.com/product_pic/hy-p1033.gif "Click to View [Pyr1]-Apelin-13 Product Detail")
![[Pyr1]-Apelin-13, Pro(13C5,15N) TFA](https://file.medchemexpress.com/product_pic/hy-p1033s1.gif "Click to View [Pyr1]-Apelin-13, Pro(13C5,15N) TFA Product Detail")
Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
apelin receptor agonist
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "apelin receptor agonist" in MCE Product Catalog:
6
Target:
Research Areas:
1
Target:
Research Areas:
Azelaprag (Example 263.0) is a candidate active molecule for an Apelin receptor agonist with an EC50 of 0.32 nM for the apelin receptor .
1
1 Cited Publications
Cat. No.: HY-P2196A
Target:
Research Areas:
Target:
Research Areas:
BMS-986224 is a potent, selective and orally active APJ receptor agonist (Kd = 0.3 nM). BMS-986224 exhibits similar receptor binding and signaling profile to (Pyr 1) apelin-13. BMS-986224 has the potential for the research of heart failure .
Target:
Research Areas:
CMF019 is an orally active, potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents . Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin. CMF019 is promising for research of chronic diseases, such as, pulmonary arterial hypertension .
Target:
Research Areas:
Target:
Research Areas:
ML233 is a non-peptide based potent apelin receptor (APJ) agonist (EC50=3.7 μM). ML233 displays >21-fold selective over the closely related angiotensin 1 (AT1) receptor (>79 μM) .
Cat. No.: HY-P1066
CAS No.: 217082-57-0
Target:
Research Areas:
Cat. No.: HY-P1064
CAS No.: 252642-12-9
Target:
Research Areas:
Cat. No.: HY-P2197
CAS No.: 1784687-32-6
Target:
Research Areas:
Cat. No.: HY-P1065
CAS No.: 230299-95-3
Target:
Research Areas:
Cat. No.: HY-P2249
CAS No.: 2245073-05-4
Target:
Research Areas:
Cat. No.: HY-147751
CAS No.: 1965244-85-2
Target:
Research Areas:
APJ receptor agonist 6 (compound 9) is a potent APJ (apelin receptor) agonist, with Ki of 1.3 μM. APJ receptor agonist 6 has EC50 values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and β-arrestin, respectively .
Cat. No.: HY-126293
CAS No.: 2227512-85-6
Target:
Research Areas:
Apelin agonist 1 is an oral selective apelin agonist AM-2995, a agonist of the APJ (APLNR, angiotensin receptor like-1) receptor, may be used in the treatment of cardiovascular conditions. Apelin agonist 1 is extracted from patent WO 2018097944 (210.0), Example 210.0 .
Cat. No.: HY-P1064A
Target:
Research Areas:
Cat. No.: HY-P1033S1
Target:
Research Areas:
Cat. No.: HY-167712
CAS No.: 2049979-31-7
Synonyms: (2R,3S)-AMG 986
Target:
Research Areas:
(2R,3S)-Azelaprag ((2R,3S)-AMG 986) (Example 238.0) is a precursor of an apelin receptor agonist (EC50=12 nM) and an isomer of Azelaprag (HY-109111) .
Cat. No.: HY-133036
CAS No.: 2287153-38-0
Target:
Research Areas:
APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure .
Cat. No.: HY-P1066A
Target:
Research Areas:
Cat. No.: HY-145285
CAS No.: 2135514-20-2
Target:
Research Areas:
APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
