10 Results for "

cardiorenal

" in MedChemExpress (MCE) Product Catalog:
Products (10)

10 Results for "cardiorenal" in MCE Product Catalog:

12
Higenamine
Higenamine
0 Images
12 Publications Verification
Cat. No.: HY-N2037
CAS No.: 5843-65-2
Synonyms: Norcoclaurine; Demethyl-Coclaurine
Category:  

Alkaloids Ranunculaceae Phenols Polyphenols  Aconitum carmichaeli Debx. Plants Disease Research Fields Isoquinoline Alkaloids Endocrinology

Target:  

MAP3K MDM-2/p53 Adrenergic Receptor ROS Kinase Apoptosis

Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
loading...
    loading...
View All Sizes
12
Higenamine hydrochloride
Higenamine hydrochloride
0 Images
12 Publications Verification
Cat. No.: HY-N2037A
CAS No.: 11041-94-4
Synonyms: Norcoclaurine hydrochloride
Category:  

Plants Lindera aggregata (Sims) Kosterm. Alkaloids Phenols Polyphenols Lauraceae Disease Research Fields Isoquinoline Alkaloids Endocrinology Cancer

Target:  

MAP3K MDM-2/p53 ROS Kinase Apoptosis

Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
loading...
    loading...
View All Sizes
9
Finerenone
Finerenone
0 Images
9 Cited Publications
Cat. No.: HY-111372
CAS No.: 1050477-31-0
Purity:  99.66%
Synonyms: BAY 94-8862
Target:  

Mineralocorticoid Receptor

Research Areas:  

Cardiovascular Disease Metabolic Disease

Finerenone (BAY 94-8862) is a third-generation, selective, and orally active nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50 = 18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (> 500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .
loading...
    loading...
View All Sizes
2
Cichoriin
Cichoriin
0 Images
2 Cited Publications
Cat. No.: HY-N8599
CAS No.: 531-58-8
Category:  

Infection other families Monophenols Coumarins Phenols Phenylpropanoids Plants Disease Research Fields

Target:  

Amylases Glycosidase Lipase Dipeptidyl Peptidase p38 MAPK PPAR P2Y Receptor NOD-like Receptor (NLR) SARS-CoV Pyroptosis GLUT Angiotensin-converting Enzyme (ACE) NF-κB

Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, α-glucosidase, pancreatic lipase and DPP-IV, with IC50 values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y14R (IC50 = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2 .
loading...
    loading...
View All Sizes
1
Finerenone-d5
Finerenone-d5
0 Images
1 Cited Publications
Cat. No.: HY-111372S1
Synonyms: BAY 94-8862-d5
Finerenone-d5 (BAY 94-8862-d5) is deuterium labeled Finerenone. Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .
loading...
    loading...
View All Sizes
Finerenone (Standard)
Finerenone (Standard)
0 Images
Cat. No.: HY-111372R
CAS No.: 1050477-31-0
Synonyms: BAY 94-8862 (Standard)
Target:  

Reference Standards Mineralocorticoid Receptor

Research Areas:  

Cardiovascular Disease

Finerenone (Standard) is the analytical standard of Finerenone. This product is intended for research and analytical applications. Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .
loading...
    loading...
View All Sizes
Finerenone-d3
Finerenone-d3
0 Images
Cat. No.: HY-111372S
CAS No.: 2917530-37-9
Synonyms: BAY 94-8862-d3
Finerenone-d3 is the deuterium labeled finerenone (HY-111372). Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .
loading...
    loading...
View All Sizes
Higenamine (Standard)
Higenamine (Standard)
0 Images
Cat. No.: HY-N2037R
CAS No.: 5843-65-2
Synonyms: Norcoclaurine (Standard); Demethyl-Coclaurine (Standard)
Category:  

Alkaloids Ranunculaceae Phenols Polyphenols  Aconitum carmichaeli Debx. Plants Isoquinoline Alkaloids

Target:  

Reference Standards MAP3K MDM-2/p53 Adrenergic Receptor ROS Kinase Apoptosis

Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
loading...
    loading...
View All Sizes
Higenamine hydrochloride (Standard)
Higenamine hydrochloride (Standard)
0 Images
Cat. No.: HY-N2037AR
CAS No.: 11041-94-4
Synonyms: Norcoclaurine hydrochloride (Standard)
Category:  

Alkaloids Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm.

Target:  

MAP3K Reference Standards MDM-2/p53 ROS Kinase Apoptosis

Higenamine (hydrochloride) (Standard) is the analytical standard of Higenamine (hydrochloride). This product is intended for research and analytical applications. Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
loading...
    loading...
View All Sizes
Higenamine-d4-1 hydrochloride
Higenamine-d4-1 hydrochloride
0 Images
Cat. No.: HY-N2037AS1
Synonyms: Norcoclaurine-d4-1 hydrochloride; Demethyl-Coclaurine-d4-1 hydrochloride
Higenamine-d4-1 (Norcoclaurine-d4-1) hydrochloride is deuterium labeled Higenamine (hydrochloride). Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
loading...
    loading...
View All Sizes
Assay Types