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Results for "

casitas B

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

6

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-155477
    Cbl-b-IN-15

    		E1/E2/E3 Enzyme Cancer
    Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ligase Cbl (IC50: 15 nM). Cbl-b refers to Casitas B-lineage lymphoma proto-oncogene-b, which inhibits T-cell, natural killer (NK) cell, and B-cell activation. Cbl-b-IN-15 activates T cell function with EC50=0.41 μM .
    Cbl-b-IN-15
  • HY-156768
    Cbl-b-IN-12

    		E1/E2/E3 Enzyme Cancer
    Cbl-b-IN-12 (Example 10) is a casitas B-lineage lymphoma-b (CBL-B) inhibitor with an IC50 of <100 nM .
    Cbl-b-IN-12
  • HY-156765
    Cbl-b-IN-9

    		E1/E2/E3 Enzyme Cancer
    Cbl-b-IN-9 (Compound 300) is a casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl inhibitor with IC50s of 5.6 nM and 4.7 nM, respectively .
    Cbl-b-IN-9
  • HY-156764
    Cbl-b-IN-8

    		E1/E2/E3 Enzyme Cancer
    Cbl-b-IN-8 (Compound 293) is a casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl inhibitor with IC50s of 5.5 nM and 7.8 nM, respectively .
    Cbl-b-IN-8
  • HY-141431
    Cbl-b-IN-2

    		E1/E2/E3 Enzyme Inflammation/Immunology Cancer
    Cbl-b-IN-2 (Example 8) is an orally bioavailable compound, can inhibit the E3 enzyme Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) in the ubiquitin proteasome pathway. Cbl-b-IN-2 can be used to modulate the immune system and diseases amenable to immune system modulation. Cbl-b-IN-2 (Example 8) also may be administered to an individual with cancer, either alone or as part of a combination, with one or more of an immune checkpoint inhibitor, an anti-neoplastic agent, and radiation agent .
    Cbl-b-IN-2
  • HY-158173
    Cbl-b-IN-19

    		E1/E2/E3 Enzyme Inflammation/Immunology Cancer
    Cbl-b-IN-19 (Compound 49) is an inhibitor for casitas B-lineage lymphoma b(Cbl-b), that inhibits Cbl-b phosphorylation with an IC50 < 100 nM .
    Cbl-b-IN-19
  • HY-156763
    Cbl-b-IN-7

    		E1/E2/E3 Enzyme Cancer
    Cbl-b-IN-7 (Compound 248) is a casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl inhibitor with IC50s of 6.7 nM and 5.2 nM, respectively .
    Cbl-b-IN-7
  • HY-156767
    Cbl-b-IN-11

    		E1/E2/E3 Enzyme Cancer
    Cbl-b-IN-11 (Compound 466) is a casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl inhibitor with IC50s of 6.4 nM and 6.1 nM, respectively .
    Cbl-b-IN-11
  • HY-158174
    Cbl-b-IN-20

    		E1/E2/E3 Enzyme Cancer
    Cbl-b-IN-20 (Example 50) is a casitas proto-oncogene-B ( CPL-B ) inhibitor with IC50 <100 nM .
    Cbl-b-IN-20
  • HY-156762
    Cbl-b-IN-6

    		E1/E2/E3 Enzyme Cancer
    Cbl-b-IN-6 (Compound 246) is a casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl inhibitor with IC50s of 6.7 nM and 5.2 nM, respectively .
    Cbl-b-IN-6
  • HY-158172
    Cbl-b-IN-18

    		E1/E2/E3 Enzyme Others
    Cbl-b-IN-18 (compound 51) is an inhibitor of the E3 ligase Casitas B-lineage lymphoma proto-oncogene B (CPL-B). Cbl-b-IN-18 inhibits the phosphorylation of CPL-B (IC50< 100 nM) .
    Cbl-b-IN-18
  • HY-169005
    Cbl-b-IN-27

    		E1/E2/E3 Enzyme Inflammation/Immunology
    Cbl-b-IN-27 is a casitas B-lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 value of 7 nM. Cbl-b-IN-27 is promising for research of effector T cell function, T cell, natural killer (NK) cell and B cell activation regulation .
    Cbl-b-IN-27
  • HY-179617
    Cbl-b-IN-30

    		E1/E2/E3 Enzyme Interleukin Related Cancer
    Cbl-b-IN-30 is an orally active Casitas B-lineage lymphoma-b (CBLB) inhibitor. Cbl-b-IN-30 specifically binds to CBLB and inhibits its E3 ubiquitin ligase activity with an IC50 of 9.1 nM. Cbl-b-IN-30 can promote IL-2 secretion (EC50 = 187.5 nM) and enhance T cell activation. Cbl-b-IN-30 exerts antitumor activity and can induce immune memory. Cbl-b-IN-30 can be used for the research of colon cancer .
    Cbl-b-IN-30

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