62 Results for "

cell+damage

" in MedChemExpress (MCE) Product Catalog:
Products (62)

62 Results for "cell+damage" in MCE Product Catalog:

92
FITC-Dextran (MW 4000)
FITC-Dextran (MW 4000)
0 Images
92 Publications Verification
Cat. No.: HY-128868A
CAS No.: 60842-46-8
FITC-Dextran (MW 4000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 4000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 4000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .
92
FITC-Dextran (MW 10000)
FITC-Dextran (MW 10000)
0 Images
92 Publications Verification
Cat. No.: HY-128868
CAS No.: 60842-46-8
FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .
12
FITC-Dextran (MW 40000)
FITC-Dextran (MW 40000)
0 Images
12 Cited Publications
Cat. No.: HY-128868D
CAS No.: 60842-46-8
FITC-Dextran (MW 40000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 40000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 40000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .
9
Lipoamide
Lipoamide
0 Images
9 Cited Publications
Cat. No.: HY-B1142
CAS No.: 940-69-2
Synonyms: (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide
Category:  

Human Gut Microbiota Metabolites Natural Products Microorganisms Other Diseases Endogenous metabolite Disease Research Fields

Target:  

NO Synthase

Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .
4
FITC-Dextran (MW 150000)
FITC-Dextran (MW 150000)
0 Images
4 Cited Publications
Cat. No.: HY-128868G
CAS No.: 60842-46-8
FITC-Dextran (MW 150000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=491 nm; Em=518 nm). FITC-Dextran (MW 150000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 150000) can be used in perfusion studies in animals or in fluorescence microlymphography, to study processes that affect the permeability of the blood brain barrier (BBB) . FITC-Dextran (MW 150000) can be used as fluorescent probe to study cell permeability .
4
Atrazine
Atrazine
0 Images
4 Cited Publications
Cat. No.: HY-N7091
CAS No.: 1912-24-9
Target:  

Environmental Pollutants Herbicide

Research Areas:  

Metabolic Disease Cancer

Atrazine, a triazine herbicide, is principally used for control of certain annual broadleaf and grass weeds. Atrazine inhibits photophosphorylation but typically does not result in lethality or permanent cell damage in the short term .
2
FITC-Dextran (MW 3000-5000)
FITC-Dextran (MW 3000-5000)
0 Images
2 Cited Publications
Cat. No.: HY-128868B
CAS No.: 60842-46-8
FITC-Dextran (MW 3000-5000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 3000-5000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 3000-5000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption . Storage: protect from light.
1
Callistephin chloride
Callistephin chloride
0 Images
1 Cited Publications
Cat. No.: HY-W040045
CAS No.: 18466-51-8
Synonyms: Pelargonidin-3-O-glucoside chloride
Category:  

Anthocyans Flavonoids Other Diseases Rosaceae Phenols Polyphenols Plants Disease Research Fields Fragaria × ananassa Duch.

Target:  

Reactive Oxygen Species (ROS) COX NO Synthase p38 MAPK TNF Receptor Apoptosis

Callistephin (Pelargonidin 3-O-glucoside) chloride is an anthocyanin. Callistephin chloride regulates the expression of inflammatory (reducing iNOS/TNF-α/COX-2) and apoptosis-related proteins by inhibiting p38 phosphorylation, and enhances the protective effect of Isoflurane (HY-A0134) on microglial cell damage. Callistephin chloride significantly reduces ROS levels, eliminates DPPH free radicals, protects retinal pigment epithelial cells, and inhibits lipid peroxidation. Callistephin chloride can alleviate glutamate excitotoxicity, reduce neuronal apoptosis, and protect cerebellar granule neurons. Callistephin chloride can inhibit the proliferation and metastasis of breast cancer cells by inducing apoptosis .
1
Rhodionin
Rhodionin
0 Images
1 Cited Publications
Cat. No.: HY-N0241
CAS No.: 85571-15-9
Category:  

Flavonols Crassulaceae Metabolic Disease Plants Rhodiola crenulata (HK. f. et.Thoms) H. Ohba Flavonoids Rhodiola rosea Linn. Phenols Polyphenols Disease Research Fields

Target:  

Cholinesterase (ChE) Lipase Bacterial Cytochrome P450

Rhodionin is an orally active, multifunctional antivirulence and cytoprotective agent that targets and inhibits Lipase, sortase A (SrtA), CYP2D6 (IC50=0.761 μM), AChE (IC50=2.43-57.5 μM), and DPPH free radicals (IC50=19.49 μM). Rhodionin is isolable from the roots of Rhodiola crenulata. Rhodionin reduces postprandial serum triglyceride levels in mice by inhibiting lipase activity. Rhodionin also binds directly to SrtA to inhibit its transpeptidase activity, thereby reducing the fibrinogen adhesion and surface protein A levels of MRSA, effectively inhibiting biofilm formation and protecting against MRSA-induced cell damage. Rhodionin improves the survival rate of infected mice without affecting MRSA growth, and finds wide application in studies related to hyperlipidemia, exogenous obesity, and pneumonia induced by methicillin-resistant Staphylococcus aureus (MRSA) .
Dehydroascorbic acid
Dehydroascorbic acid
0 Images
Cat. No.: HY-110281
CAS No.: 490-83-5
Purity:  95.57%
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Endogenous Metabolite

Dehydroascorbic acid is an oxidized form of vitamin C that can cross the blood-brain barrier (BBB). Dehydroascorbic acid clears cytotoxic reactive oxygen species (ROS) produced after ischemic stroke by converting to ascorbic acid (AA), thereby reducing neuronal and glial cell damage and stabilizing cerebral microvascular NO signaling to maintain perfusion in the ischemic area. Dehydroascorbic acid can be used in research on ischemic stroke .
2-O-α-D-Glucopyranosyl-L-ascorbic Acid
2-O-α-D-Glucopyranosyl-L-ascorbic Acid
0 Images
Cat. No.: HY-N6821
CAS No.: 129499-78-1
Target:  

Drug Derivative

Research Areas:  

Inflammation/Immunology Cancer

2-O-α-D-Glucopyranosyl-L-ascorbic Acid is an orally active glucoside derivative of ascorbic acid. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid can be hydrolyzed by α-glucosidase to release ascorbic acid. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid inhibits melanin synthesis, prevents UV-induced cell damage, and promotes collagen synthesis in skin fibroblasts. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid also induces oxidative stress to inhibit tumor growth. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid can be used in research related to tumors, inflammation, and other conditions .
FITC-Dextran (MW 10000) (solution)
FITC-Dextran (MW 10000) (solution)
0 Images
Cat. No.: HY-DY1016
CAS No.: 60842-46-8
FITC-Dextran (MW 10000) (solution) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .
Solvent and Concentration: Sterile water: 2 mM
Galloylpaeoniflorin
Galloylpaeoniflorin
0 Images
Cat. No.: HY-N5048
CAS No.: 122965-41-7
Synonyms: 6'-O-Galloyl paeoniflorin
Category:  

Paeonia lactiflora Pall. Other Diseases Phenols Polyphenols Plants Paeoniaceae Disease Research Fields

Target:  

NF-κB ERK JNK Nuclear Factor of activated T Cells (NFAT) Keap1-Nrf2 PI3K Akt Reactive Oxygen Species (ROS) Apoptosis DNA/RNA Synthesis

Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) is an orally active galloylated derivative of Paeoniflorin (HY-N0293) found in peony roots with various anti-inflammatory and antioxidant activities. Galloylpaeoniflorin suppresses RANKL-induced activation of ERK, JNK, c-Fos, c-Jun, and NFATc1, and reduces osteoclast-specific gene expression. Galloylpaeoniflorin activates Nrf2 and PI3K/Akt pathways, inhibits NF-κB activation, and scavenges ROS to reduce oxidative DNA, lipid, and protein damage. Galloylpaeoniflorin attenuates neuroinflammation, inhibits apoptosis, reduces Helicobacter pylori-induced gastric mucosa injury and UVB-induced cell damage. Galloylpaeoniflorin can be used for the research of osteoporosis, gastritis, ischemic stroke and skin diseases .
2-Iminobiotin
2-Iminobiotin
0 Images
Cat. No.: HY-118700
CAS No.: 13395-35-2
Purity:  99.88%
Synonyms: Guanidinobiotin
Target:  

NO Synthase

Research Areas:  

Neurological Disease

2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5μM for murine iNOS and rat n-cNOS, respectively . 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage .
Avacincaptad pegol
Avacincaptad pegol
0 Images
Cat. No.: HY-148457
CAS No.: 1613641-69-2
Synonyms: Izervay
Target:  

Complement System

Research Areas:  

Infection Neurological Disease Inflammation/Immunology

Avacincaptad pegol (Izervay) is a selective inhibitor targeting complement component C5, and is a pegylated ribonucleic acid aptamer. Avacincaptad pegol inhibits the cleavage of C5 into pro-inflammatory C5a and C5b, which forms the membrane attack complex (C5b-9), thereby reducing inflammatory cell recruitment and retinal cell damage. Avacincaptad pegol can slow the growth of geographic atrophy (GA) lesions and reduce the risk of persistent vision loss. Avacincaptad pegol can be used in research of geographic atrophy associated with age-related macular degeneration (AMD) and has been approved by the FDA .
Diphenylamine hydrochloride
Diphenylamine hydrochloride
0 Images
Cat. No.: HY-N7133
CAS No.: 537-67-7
Synonyms: N-Phenylaniline hydrochloride
Category:  

Natural Products Other Diseases Amberboa moschata (L.) DC. Plants Umbelliferae Disease Research Fields

Target:  

Fungal Bacterial

Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent .
Nigakinone
Nigakinone
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Cat. No.: HY-N2128
CAS No.: 18110-86-6
Category:  

Alkaloids Simaroubaceae Plants Disease Research Fields Inflammation/Immunology  Picrasma quassioides(D．Don)Benn． Indole Alkaloids

Target:  

FXR NOD-like Receptor (NLR)

Nigakinone is an orally active FXR agonist and NLRP3 inhibitor. Nigakinone suppresses bile acid-induced inflammation and cell damage, regulates the bile acid profile, and alleviates intestinal mucosal barrier injury. Nigakinone synergizes with Irinotecan (HY-16562) to inhibit the proliferation and migration of colorectal cancer cells as well as the growth of subcutaneous xenograft tumors. Nigakinone can be used in research related to ulcerative colitis and colorectal cancer .
Atrazine-d5
Atrazine-d5
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Cat. No.: HY-N7091S2
CAS No.: 163165-75-1
Atrazine-d5 is deuterium labeled Atrazine. Atrazine is principally used for control of certain annual broadleaf and grass weeds. Atrazine inhibits photophosphorylation but typically does not result in lethality or permanent cell damage in the short term .
L-Ornithine monohydrochloride,suitable for cell culture
L-Ornithine monohydrochloride,suitable for cell culture
0 Images
Cat. No.: HY-W017018B
CAS No.: 3184-13-2
L-Ornithine monohydrochloride,suitable for cell culture is a CaSR activator and p38 activator suitable for cell culture. L-Ornithine monohydrochloride,suitable for cell culture inhibits ROS and supports urea cycle function. L-Ornithine monohydrochloride,suitable for cell culture can be used to study kidney diseases involving proximal tubular cell damage caused by oxidative stress or crystallopathy, as well as research related to anxiety disorders .
YM-244769
YM-244769
0 Images
Cat. No.: HY-136182A
CAS No.: 838819-70-8
Purity:  99.22%
Target:  

Na+/Ca2+ Exchanger

Research Areas:  

Cardiovascular Disease Neurological Disease

YM-244769 is a potent, selective and orally active Na +/Ca 2+ exchanger (NCX) inhibitor. YM-244769 preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca 2+ entry mode), with IC50s of 18 nM and 50 nM, respectively. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 can also increase urine volume and urinary excretion of electrolytes in mice .
Assay Types