490-83-5
490-83-5
Chemical Structure
Dehydroascorbic acid
- CAS No.: 490-83-5
- Formula:C6H6O6
- Molecular Weight:174.11
IUPAC Name: (R)-5-((S)-1,2-dihydroxyethyl)furan-2,3,4(5H)-trione
InChIKey: SBJKKFFYIZUCET-JLAZNSOCSA-N
SMILES: OC[C@H](O)[C@]([H])(C(C1=O)=O)OC1=O
Biological Activity: Dehydroascorbic acid is an oxidized form of vitamin C that can cross the blood-brain barrier (BBB). Dehydroascorbic acid clears cytotoxic reactive oxygen species (ROS) produced after ischemic stroke by converting to ascorbic acid (AA), thereby reducing neuronal and glial cell damage and stabilizing cerebral microvascular NO signaling to maintain perfusion in the ischemic area. Dehydroascorbic acid can be used in research on ischemic stroke[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dehydroascorbic acid | 99.94% | Dehydroascorbic acid is an oxidized form of vitamin C that can cross the blood-brain barrier (BBB). Dehydroascorbic acid clears cytotoxic reactive oxygen species (ROS) produced after ischemic stroke by converting to ascorbic acid (AA), thereby reducing neuronal and glial cell damage and stabilizing cerebral microvascular NO signaling to maintain perfusion in the ischemic area. Dehydroascorbic acid can be used in research on ischemic stroke. | ||||||||||||||||||||
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Dehydroascorbic acid (Standard) | 99.83% | Dehydroascorbic acid (Standard) is the analytical standard of Dehydroascorbic acid. This product is intended for research and analytical applications. Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke. | ||||||||||||||||||||
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1,4-D-Gulonolactone | 99.56% | 1,4-D-Gulonolactone is an endogenous metabolite. | ||||||||||||||||||||
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Saccharolactone | Saccharolactone is a potent orally active β-glucuronidase inhibitor. Saccharolactone markedly lowers biliary endogenous β-glucuronidase activity in the rat bile. Saccharolactone can stabilize glucuronide metabolites in vitro. Saccharolactone is also a strong inhibitor of CYP1A2, 2D6, 3A4 and 2C8 isoforms (IC50 < 4 mM). | |||||||||||||||||||||
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D-Glucuronic acid lactone | 98.0% | D-Glucuronic acid lactone (D-Glucurono-6,3-lactone; D-Glucurono-γ-lactone; D-Glucuronolactone; Dicurone; Glucoxy; Glucurolactone; Glucurone) is an endogenous metabolite and a glucuronic acid derivative. D-Glucuronic acid lactone serves as a starting reagent for the synthesis of 2,3,4-tris (tert-butyldimethylsilyl) glucuronic acid trichloroethyl ester, which is used to prepare 1-O-acyl glucuronic acids for the anti-inflammatory agent mL-3000 (HY-B1452), synthesize optically active glucuronic acids, and produce long-chain alkyl glucuronides. D-Glucuronic acid lactone shows potential for use in studies of reversible cerebral vasoconstriction syndrome (RCVS). | ||||||||||||||||||||
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L-Gulono-1,4-lactone (Standard) | ≥98% | L-Gulono-1,4-lactone (L-Gulonolactone) (Standard) is the analytical standard of L-Gulono-1,4-lactone. This product is intended for research and analytical applications. L-Gulono-1,4-lactone is a biosynthetic precursor of L-Ascorbic acid (Vitamin C) (HY-B0166). L-Gulono-1,4-lactone can be enzymatically converted to L-Ascorbic acid via the animal uronic acid pathway, while species such as humans lack the key oxidase that catalyzes this step, resulting in the disruption of this pathway and the necessity to obtain Vitamin C from diet. L-Gulono-1,4-lactone is a putative intermediate in an alternative biosynthetic pathway of L-Ascorbic acid in Arabidopsis thaliana. | ||||||||||||||||||||
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D-Glycero-D-gulo-heptono-1,4-lactone | 99.93% | D-Glycero-D-gulo-heptono-1,4-lactone is a kind of biological materials or organic compounds that are widely used in life science research. | ||||||||||||||||||||
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D-Glucono-1,4-lactone | D-Glucono-1,4-lactone is a derivative of D-gluconic acid (HY-Y0569C). D-Glucono-1,4-lactone can be isolated from fruits, vegetables, honey, kombucha and wine. D-Glucono-1,4-lactone inhibits thrombin-induced arachidonic acid peroxidation and platelet activation. D-Glucono-1,4-lactone reduces superoxide anion production in thrombin-activated platelets. D-Glucono-1,4-lactone exerts antioxidant activity on platelets under oxidative stress conditions and prevents excessive platelet activation through antioxidant mechanisms. D-Glucono-1,4-lactone can be used in research related to cardiovascular diseases. | |||||||||||||||||||||
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D-Mannonic acid-1,4-lactone | D-Mannonic acid-1,4-lactone is a kind of biochemical reagent. | |||||||||||||||||||||
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L-Galactono-1,4-lactone | 98.0% | L-Galactono-1,4-lactone is a kind of biochemical reagent. | ||||||||||||||||||||
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D-Talonic acid,γ-lactone | D-Talonic acid,γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology. | |||||||||||||||||||||
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L-Allono-1,4-lactone | L-allono-1, 4-Lactone is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology. | |||||||||||||||||||||
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References
- [1]. Huang J, et al. Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potentcerebroprotection in experimental stroke. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11720-4. [Content Brief]
- [2]. Huang J, et al. Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11720-4. [Content Brief]
