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11 Results for "
chymase inhibitor
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "chymase inhibitor" in MCE Product Catalog:
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Fulacimstat is an orally available chymase inhibitor, with IC50s of 4, 3 nM for human and hamster chymase enzyme, respectively.
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1 Cited Publications
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TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively.
Cat. No.: HY-122161
CAS No.: 518062-14-1
Synonyms: RWJ-355871
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JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity .
Cat. No.: HY-100269
CAS No.: 862090-74-2
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Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.
Cat. No.: HY-168904
CAS No.: 1236524-95-0
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BI-1942, a chemical probe, is a chymase inhibitor and has an IC50 of 0.4 nM for human chymase. BI-1942 can be used in the research of ophthalmic diseases .
Cat. No.: HY-12514
CAS No.: 204460-24-2
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NK3201 is an orally active chymase inhibitor (IC50: 2.5, 1.2, and 28 nM for human, dog and hamster chymase). NK3201 inhibits Bleomycin (HY-17565)-induced pulmonary fibrosis. NK3201 inhibits vascular proliferation in grafted vein .
Cat. No.: HY-126988
CAS No.: 70857-49-7
Synonyms: α-MAPI
SP-Chymostatin B (α-MAPI) is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, H, and L. SP-Chymostatin B weakly inhibits human leucocyte elastase .
Cat. No.: HY-16707
CAS No.: 252557-97-4
Synonyms: Z-Ile-Glu-Pro-Phe-Ome
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Cat. No.: HY-Y0370
CAS No.: 56341-37-8
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6-Chlorooxindole (compound 2) is a selective chymase inhibitor with an IC50 of 470 μM. 6-Chlorooxindole shows >100-fold selectivity for chymase over cathepsin G. 6-Chlorooxindole can be used for the study of cardiovascular disease .
Cat. No.: HY-180131
CAS No.: 1312993-34-2
Synonyms: ASB17061
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INVA8001 (ASB17061) is a highly selective and orally active chymase inhibitor with IC50 values for human chymase and mouse mast cell proteinase 4 (mMCP-4) of 0.02 and 0.03 μM, respectively. INVA8001 exhibits IC50 values for bovine α-chymotrypsin and human cathesin G of 3.4 and 32.1 μM, respectively, and it shows over 1000-fold selectivity for other related serine proteases. INVA8001 inhibits mast cells in a mouse primary sclerosing cholangitis (PSC) model, improves bile duct pathology, and alleviates bile stasis, demonstrating anti-inflammatory and anti-fibrotic effects .
Cat. No.: HY-105360
CAS No.: 130370-59-1
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GI-129471 is a MMP inhibitor. GI-129471 exhibits inhibitory activity against cancer cell invasion. GI-129471 can completely block the enhanced production of IgE and IgG1 by mouse B cells induced by rat mast cell protease-I (RMCP-I). GI-129471 can be used for the study of cancer and mast cell chymase-regulated immunological processes .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
