12 Results for "

cortistatin A

" in MedChemExpress (MCE) Product Catalog:
Products (12)

12 Results for "cortistatin A" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-122586
CAS No.: 642008-81-9
Purity:  99.56%
Target:  

CDK Interleukin Related

Research Areas:  

Inflammation/Immunology

BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates IL-10. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes .
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1 Cited Publications
Cat. No.: HY-P1932
CAS No.: 186901-48-4
Cortistatin-14 is a neuropeptide that shares structural similarities with somatostatin, working by binding to somatostatin receptors (sst1-sst5). Cortistatin-14 (TFA) has anticonvulsant, neuroprotective effects, and significant anti-inflammatory properties .
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1 Cited Publications
Cat. No.: HY-P1932A
Cortistatin-14 (TFA), a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 (TFA) shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties .
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Cat. No.: HY-P1212
CAS No.: 193829-96-8
Synonyms: CST-14 (mouse, rat)
Target:  

Somatostatin Receptor

Research Areas:  

Neurological Disease

Cortistatin 14, mouse, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus .
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Cat. No.: HY-69055
CAS No.: 58794-09-5
7-Bromoisoquinoline is a brominated isoquinoline and synthetic precursor that constructs the isoquinoline functional group at the C17 position of target molecules. 7-Bromoisoquinoline serves as a key synthetic intermediate for the synthesis of cortistatin A-derived anti-angiogenic steroidal analogs (e.g., 7-tributylstannyl isoquinoline). 7-Bromoisoquinoline .
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Cat. No.: HY-P1139
CAS No.: 485803-62-1
Synonyms: PCFWKTCK
Target:  

GHSR

Research Areas:  

Metabolic Disease

Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals .
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Cat. No.: HY-P5014
CAS No.: 1815618-16-6
Target:  

Somatostatin Receptor

Research Areas:  

Inflammation/Immunology Cancer

Cortistatin-29 (human) is a somatostatin neuropeptide with potential for studying diseases such as cancer, inflammation, autoimmunity, fibrosis, and pain .
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Cat. No.: HY-P5011
CAS No.: 189450-19-9
Target:  

Somatostatin Receptor

Research Areas:  

Inflammation/Immunology Cancer

Cortistatin-17 (human) is a somatostatin neuropeptide with potential for studying diseases such as cancer, inflammation, autoimmunity, fibrosis, and pain .
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Cat. No.: HY-P3618
Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects .
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Cat. No.: HY-P2150
CAS No.: 1815618-17-7
Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects .
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Cat. No.: HY-P11663
CAS No.: 1683515-77-6
Target:  

Drug Derivative

Research Areas:  

Inflammation/Immunology

Abantide is a cortistatin analogue with anti-inflammatory and immunomodulator effects .
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Cat. No.: HY-182885
CAS No.: 1839052-99-1
Synonyms: EPEMA
2-(Ethyl (propyl) amino) ethyl methacrylate (EPEMA) is an acid-responsive reagent and chemical intermediate. 2-(Ethyl (propyl) amino) ethyl methacrylate can be used for the synthesis of pDMA-pEPEMA. The protonation of 2-(Ethyl (propyl) amino) ethyl methacrylate in pDMA-pEPEMA under acidic conditions triggers the responsive release of Cortistatin. 2-(Ethyl (propyl) amino) ethyl methacrylate can be used in the research of diabetic ulcers .
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