193829-96-8
Chemical Structure
Cortistatin 14 (mouse, rat)
Synonym(s): CST-14 (mouse, rat)
- CAS No.: 193829-96-8
- Formula:C81H113N19O19S2
- Molecular Weight:1721.01
IUPAC Name: ((4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-22-((1H-indol-3-yl)methyl)-31-(2-amino-2-oxoethyl)-19,34-bis(4-aminobutyl)-13,25,28-tribenzyl-16-((R)-1-hydroxyethyl)-7,10-bis(hydroxymethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-37-((S)-pyrrolidine-2-c
InChIKey: DDRPLNQJNRBRNY-WYYADCIBSA-N
SMILES: [H]N1CCC[C@H]1C(N[C@H]2CSSC[C@@H](C(N[C@H](C(O)=O)CCCCN)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC2=O)CCCCN)=O)CC(N)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4)=O)CC5=CNC6=C5C=CC=C6)=O)CCCCN)=O)=O)CC7=CC=CC=C7)=O)CO)=O)CO)=O)=O
Biological Activity: Cortistatin 14, mouse, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus[1][2].
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Cortistatin 14 (mouse, rat) | 99.45% | Cortistatin 14, mouse, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus. | ||||||||||||||||||||
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References
- [1]. Jiang J, et al. Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via MediatingGhrelin and GABAA Receptor Signaling Pathway. Front Pharmacol. 2018 Jul 19;9:767. [Content Brief]
- [2]. de Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381(6579):242-5. [Content Brief]
