65 Results for "

docosahexaenoic

" in MedChemExpress (MCE) Product Catalog:
Products (65)

65 Results for "docosahexaenoic" in MCE Product Catalog:

50
50 Publications Verification
Cat. No.: HY-B2167
CAS No.: 6217-54-5
Synonyms: DHA; Cervonic acid
Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.
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6
6 Cited Publications
Cat. No.: HY-116429
CAS No.: 1268720-28-0
Purity:  99.00%
Research Areas:  

Inflammation/Immunology

Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca 2+] and secretion. Maresin 1 possesses anti-inflammatory activity .
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5
5 Cited Publications
Cat. No.: HY-121636
CAS No.: 810668-37-2
Purity:  99.90%
Synonyms: RvD2
Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons .
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1
1 Cited Publications
Cat. No.: HY-125527
CAS No.: 872993-05-0
Purity:  ≥99.0%
Synonyms: RvD1
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .
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1
1 Cited Publications
Cat. No.: HY-130289
CAS No.: 90906-40-4
Synonyms: 4-Hydroxy docosahexaenoic acid; (±)4-HDoHE
Target:  

PPAR

(±)4-HDHA (4-Hydroxy docosahexaenoic acid) is an autoxidation product of Docosahexaenoic acid (HY-B2167) (DHA). (±)4-HDHA is a PPARγ agonist, antidiabetic and anti-inflammatory agent .
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Cat. No.: HY-130413
CAS No.: 660430-03-5
Synonyms: Neuroprotectin D1; NPD1
Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders .
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Cat. No.: HY-B2167R
CAS No.: 6217-54-5
Synonyms: DHA (Standard); Cervonic acid (Standard)
Docosahexaenoic acid (Standard) is the analytical standard of Docosahexaenoic acid. This product is intended for research and analytical applications. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk. In Vitro: Docosahexaenoic acid (DHA) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults. The inclusion of plentiful DHA in the diet improves learning ability and memory . DHA is an essential requirement in every step of brain development like neural cell proliferation, migration, differentiation, synaptogenesis. The multiple double bonds and unique structure allow DHA to impart special membrane characteristics for effective cell signaling. Many development disorders like dyslexia, autism spectrum disorder, attention deficit hyperactivity disorder, schizophrenia etc. are causally related to decreased level of DHA . DHA is a potent RXR ligand inducing robust RXR activation already at low micro molar concentrations. The EC50 for RXRα activation by DHA is about 5-10 μM fatty acid . In Vivo: Docosahexaenoic acid administration over 10 weeks significantly reduces the number of reference memory errors, without affecting the number of working memory errors, and significantly increases the docosahexaenoic acid content and the docosahexaenoic acid/arachidonic acid ratio in both the hippocampus and the cerebral cortex . DHA treatment exerts neuroprotective actions on an experimental mouse model of PD. There is a decrease tendency in brain lipid oxidation of MPTP mice but it does not significantly .
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Cat. No.: HY-107343
CAS No.: 81926-94-5
Purity:  96.22%
Synonyms: Ethyl docosahexaenoate
Target:  

COX

Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects .
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Cat. No.: HY-101541
CAS No.: 2566-90-7
Purity:  ≥95.0%
Synonyms: Methyl docosahexaenoate; all cis-DHA methyl ester
Target:  

Drug Intermediate

Research Areas:  

Neurological Disease

Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.
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Cat. No.: HY-B2167S
CAS No.: 1197205-71-2
Synonyms: DHA-d5; Cervonic acid-d5
Docosahexaenoic acid-d5 is the deuterium labeled Docosahexaenoic Acid. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.
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Cat. No.: HY-112247
CAS No.: 2088135-12-8
Purity:  99.89%
SR 16832 is a dual-site covalent, orthosteric and allosteric PPARγ antagonist. SR 16832 activates the TGF-β signaling pathway and upregulates the expression of Vimentin and Fibronectin (Fibronectin). SR 16832 is toxic to bronchial epithelium. SR 16832 can be used in research related to type 2 diabetes and pulmonary fibrosis .
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Cat. No.: HY-142989
CAS No.: 99296-81-8
Purity:  97.3%
Target:  

Liposome HIV HCV HBV

Research Areas:  

Infection Cancer

1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine is a polyunsaturated phospholipid that serves as a component of lipid monolayers and small unilamellar vesicles. 1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine can be used to prepare endoplasmic reticulum-targeted liposomes (PERLs), which are composed of 1,2-didocosahexaenoyl-sn-glycero-3-phosphoethanolamine, l-α-phosphatidylinositol and l-α-phosphatidylserine at a molar ratio of 1.5:1.5:1:1. PERLs reduce cholesterol levels in human peripheral blood mononuclear cells (PBMCs) and decrease HIV-1 particle secretion from HIV-1-infected PBMCs. Liposomes formed from 1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine exhibit cytotoxicity against leukemia cells. 1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine is applicable to studies related to hepatitis C virus infection, HIV infection, hepatitis B virus infection and leukemia .
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Cat. No.: HY-130239A
CAS No.: 87042-40-8
Synonyms: (±)14-HDoHE; 14-hydroxy docosahexaenoic acid; (±)14-HDoHE
Target:  

Drug Metabolite

Research Areas:  

Neurological Disease

(±)14-HDHA is the isomer of 14(S)-HDHA (HY-130239). 14(S)-HDHA is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway .
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Cat. No.: HY-130239
CAS No.: 119433-37-3
Purity:  ≥98.0%
Synonyms: 14(S)-HDoHE
Target:  

Drug Metabolite

Research Areas:  

Neurological Disease

14(S)-HDHA (14(S)-HDoHE) is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway .
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Cat. No.: HY-B2167S2
Docosahexaenoic acid- 13C4 is 13C labeled Docosahexaenoic acid. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk .
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Cat. No.: HY-120442
CAS No.: 1345275-27-5
Target:  

COX

Research Areas:  

Cardiovascular Disease

(±)16(17)-DiHDPA is a epoxygenase metabolite of docosahexaenoic acid (HY-B2167). (±)16(17)-DiHDPA inhibits platelet aggregation at concentrations below those affecting thromboxane synthesis .
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Cat. No.: HY-130286
CAS No.: 90780-50-0
Research Areas:  

Metabolic Disease

10-Hydroxy-4(Z),7(Z),11(E),13(Z),16(Z),19(Z)-docosahexaenoic acid is an ester product.
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Cat. No.: HY-136540
CAS No.: 916888-47-6
Synonyms: RvD3
Target:  

AMPK Autophagy

Research Areas:  

Inflammation/Immunology

Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation .
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Cat. No.: HY-148940
CAS No.: 140670-40-2
Purity:  ≥99.0%
Target:  

Cannabinoid Receptor

Research Areas:  

Inflammation/Immunology

Docosahexaenoyl glycerol is a glyceride, monoacylglycerol, and endocannabinoid analog derived from docosahexaenoic acid (DHA) (HY-B2167), with anti-inflammatory properties and glucose uptake-stimulating activity in vitro .
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Cat. No.: HY-107343R
CAS No.: 81926-94-5
Synonyms: Ethyl docosahexaenoate (Standard)
Docosahexaenoic acid ethyl ester (Standard) is the analytical standard of Docosahexaenoic acid ethyl ester. This product is intended for research and analytical applications. Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects .
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