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Cat. No.: HY-130289

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(±)4-HDHA

(Synonyms: 4-Hydroxy docosahexaenoic acid; (±)4-HDoHE)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

(±)4-HDHA (4-Hydroxy docosahexaenoic acid) is an autoxidation product of Docosahexaenoic acid (HY-B2167) (DHA). (±)4-HDHA is a PPARγ agonist, antidiabetic and anti-inflammatory agent.

For research use only. We do not sell to patients.

Purity: 97.97%
CAS No.: 90906-40-4
Formula: C₂₂H₃₂O₃
Molecular Weight:344.49

Storage:

Solution, -20°C, 2 years

(±)4-HDHA Chemical Structure

CAS No.: 90906-40-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(±)4-HDHA (4-Hydroxy docosahexaenoic acid) is an autoxidation product of Docosahexaenoic acid (HY-B2167) (DHA). (±)4-HDHA is a PPARγ agonist, antidiabetic and anti-inflammatory agent^[1]^[2].

IC₅₀ & Target^[1]

PPARγ

All PPAR Isoforms :

Chemical Information

CAS No. 90906-40-4
Appearance Liquid
Molecular Weight 344.49
Formula C₂₂H₃₂O₃
Color Colorless to light yellow
SMILES

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C=C\C(O)CCC(O)=O
Synonyms

4-Hydroxy docosahexaenoic acid; (±)4-HDoHE
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years

Publications (1)

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Cell

Stabilizing MARCH7 as a ferro-guardian against ferroptosis. [Abstract]

2026 Jun 11;189(12):3553-3570.e30. PMID: 42049018

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yamamoto K, et al. 4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor gamma agonist alleviates the symptoms of DSS-induced colitis. Biochem Biophys Res Commun. 2008 Mar 14;367(3):566-72. [Content Brief]

[2]. Richard Louis Dunbar, et al. Lymph-releasing compositions of fatty acids and uses thereof for lymphatic incorporation and systemic disease treatment. Patent. WO2023146984.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (1)
Purity & Documentation
References

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(±)4-HDHA

Publications Citing Use of MedChemExpress (MCE) (±)4-HDHA

All PPAR Isoforms