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elongation

" in MedChemExpress (MCE) Product Catalog:

153

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7

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6

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1

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41

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Products

7

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8

Isotope-Labeled Compounds

27

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4

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14944
    Homoharringtonine
    Maximum Cited Publications
    35 Publications Verification

    Omacetaxine mepesuccinate; HHT

    		 STAT Cancer
    Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.
    Homoharringtonine
  • HY-N0273
    Brassinolide
    4 Publications Verification

    Brassin lactone

    		 Apoptosis Cancer
    Brassinolide is a predominant plant growth modulator that regulate plant cell elongation.
    Brassinolide
  • HY-114489A
    Haemanthamine

    		Apoptosis Influenza Virus Parasite Infection Neurological Disease Cancer
    Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities .
    Haemanthamine
  • HY-134575
    C24:1-Ceramide

    		Apoptosis GSK-3 Others
    C24:1-Ceramide is one of the most abundant naturally occurring ceramide. Ceramides regulates many diverse biological activities, such as cell apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain .
    C24:1-Ceramide
  • HY-B1350
    Fusidic acid
    2 Publications Verification

    Fusidate; SQ-16603

    		 Bacterial Antibiotic Infection Cancer
    Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome. Fusidic acid holds promise for research in anticancer and anti-infective applications. .
    Fusidic acid
  • HY-145272
    ELOVL1-IN-3
    1 Publications Verification

    		 ELOVL Neurological Disease
    ELOVL1-IN-3 (Compound 22) is a potent and orally active inhibitor of elongation of very long chain fatty acid 1 (ELOVL1) enzyme. ELOVL1-IN-3 serves as a useful tool for researching adrenoleukodystrophy (ALD) [1].
    ELOVL1-IN-3
  • HY-100576
    NH125
    2 Publications Verification

    		 CaMK Autophagy Bacterial Fungal Virus Protease Infection Cancer
    NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII) with an IC50 of 60 nM for eEF-2K. NH125 kills methicillin-resistant S. aureus (MRSA) persisters by interacting with and disrupting membranes .
    NH125
  • HY-B1350A
    Fusidic acid sodium salt
    2 Publications Verification

    Sodium fusidate; SQ-16360

    		 Bacterial Antibiotic Interleukin Related Infection Inflammation/Immunology
    Fusidic acid sodium salt is an orally available antibacterial agent that inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid sodium salt inhibits the inhibitory and activating effects of interleukins IL-1 and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat model. Fusidic acid sodium salt improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice .
    Fusidic acid sodium salt
  • HY-123972
    SEC inhibitor KL-2
    1 Publications Verification

    KL-2

    		 DNA/RNA Synthesis Cancer
    SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM .
    SEC inhibitor KL-2
  • HY-80003
    QL47

    		Flavivirus Dengue Virus Btk Infection Cancer
    QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47 selectively inhibits eukaryotic translation. QL47 is a potent covalent inhibitor of BTK with an IC50 of 7 nM .
    QL47
  • HY-120118
    Metarrestin

    ML246

    		 DNA/RNA Synthesis Cancer
    Metarrestin (ML246) is an orally active, first-in-class and specific perinucleolar compartment inhibitor. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Metarrestin blocks metastatic development and extends survival in mouse cancer models .
    Metarrestin
  • HY-N9599
    Roridin A

    		Fungal Endogenous Metabolite Parasite Insecticide Infection
    Roridin A acts as an inhibitor of pollen development in Arabidopsis thaliana and nematicide. Roridin A is isolated from the fungus Cylindrocarpon sp. Roridin A delays the flowering time of Arabidopsis thaliana, inhibits pollen development and stem elongation, and blocks plant growth. Roridin A induces larval death of the southern root-knot nematode (Meloidogyne incognita) .
    Roridin A
  • HY-B0435
    Roxithromycin
    5+ Cited Publications

    RU-28965

    		 Bacterial Antibiotic Apoptosis p38 MAPK NF-κB Infection Cardiovascular Disease Inflammation/Immunology Cancer
    Roxithromycin (RU-28965) is an orally active semi-synthethic macrolide antibiotic. Roxithromycin inhibits protein biosynthesis in the elongation step by binding to 50S bacterial ribosome. Roxithromycin has antimicrobial, antiproliferative, anti-inflammatory, tumour vasculature inhibiting and lung injury ameliorating effects .
    Roxithromycin
  • HY-N10568
    Gibberellin A9

    		Phytohormone Others
    Gibberellin A9 is a plant hormone that targets gibberellin receptor GID1. Gibberellin A9 binds to GID1 to form a GA-GID1-DELLA protein complex, which promotes the degradation of DELLA proteins. This relieves the inhibitory effect of DELLA proteins on plant growth, thereby promoting plant cell elongation and division, and increasing seed germination rate. Gibberellin A9 is promising for use in studies on plant growth and development, such as stem elongation and flowering induction .
    Gibberellin A9
  • HY-172815
    IDB-001

    		JNK Eukaryotic Initiation Factor (eIF) p38 MAPK Cancer
    IDB-001 is a human ribosomal peptidyl transferase center (PTC) inhibitor that induces conformational changes and blocks translational elongation in specific sequence contexts through complementary interactions with Asp/Glu residues in nascent polypeptides. IDB-001 preferentially stalls ribosomes at positions containing acidic peptide motifs, thereby inhibiting cancer cell proliferation, and activates the integrated stress response via eIF2α phosphorylation at high concentrations. In addition, IDB-001 mildly triggers ribotoxic stress responses through phosphorylation of JNK and p38. IDB-001 has been applied to mechanistic studies of triple-negative breast cancer .
    IDB-001
  • HY-122464S2
    (±)-Jasmonic acid-d5

    		Isotope-Labeled Compounds Others
    (±)-Jasmonic acid-d5 is the deuterium labeled (±)-Jasmonic acid. (±)-Jasmonic acid is a plant growth regulator and a derivative of α-linolenic acid. (±)-Jasmonic acid decreases chlorophyll levels in green and etiolated barley leaf segments and inhibits elongation of rice seedlings.
    (±)-Jasmonic acid-d5
  • HY-143584
    AZ5576

    		CDK Apoptosis Cancer
    AZ5576 is a potent and highly selective CDK9 inhibitor (IC50: <5 nM). AZ5576 inhibits the phosphorylation of RNA polymerase II at Ser2, thereby inhibiting transcriptional elongation. AZ5576 can be used for hematological Malignancy research .
    AZ5576
  • HY-150287A
    Insulin-Transferrin-Selenium-Ethanolamine

    ITS-X

    		 Biochemical Assay Reagents Others
    Insulin-Transferrin-Selenium-Ethanolamine (ITS-X) is a cell culture supplement as well as a cell growth and adhesion promoter. Insulin-Transferrin-Selenium-Ethanolamine supports adhesion, pseudopodium formation, pseudopodium elongation and proliferation of adherent cancer cells in serum-free culture systems .
    Insulin-Transferrin-Selenium-Ethanolamine
  • HY-145270
    ELOVL1-IN-2

    		ELOVL Metabolic Disease
    ELOVL1-IN-2 is an elongation of very long chain fatty acid 1 (ELOVL1) enzyme inhibitor, ELOVL1-IN-2 shows weak ELOVL1 inhibition (IC50=21 μM) and moderate potency in a primary cellular assay (HEK293 C26 IC50=6.7 μM) .
    ELOVL1-IN-2
  • HY-B0771A
    Cefozopran hydrochloride

    SCE-2787 hydrochloride

    		 Antibiotic Bacterial Penicillin-binding protein (PBP) Infection
    Cefozopran (SCE-2787) hydrochloride is a potent antibiotic with broad-spectrum antibacterial activity. Cefozopran hydrochloride binds PBPs, induces cell wall destruction, cell elongation, filamentation, irregular septa formation, and bactericidal, bacteriolytic activity. Cefozopran hydrochloride reduces bacterial counts and eradicates bacteria in mouse respiratory, urinary, and thigh muscle infections. Cefozopran hydrochloride can be used for the research of bacterial infections .
    Cefozopran hydrochloride
  • HY-18979
    Lactimidomycin
    1 Publications Verification

    		 Flavivirus Dengue Virus Infection Cancer
    Lactimidomycin is a glutarimide-containing compound isolated from Streptomyces. Lactimidomycin is a potent inhibitor of eukaryotic translation elongation. Lactimidomycin has a potent antiproliferative effect on tumor cell lines and selectively inhibit protein translation. Lactimidomycin inhibits protein synthesis with an IC50 value of 37.82 nM. Lactimidomycin is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Anticancer and antiviral activities .
    Lactimidomycin
  • HY-121231
    trans-Caffeic acid

    		Others Others
    trans-Caffeic acid is a growth stimulator that enhances the elongation growth of coleoptile sections .
    trans-Caffeic acid
  • HY-141567A
    Pseudouridine 5'-triphosphate trisodium solution (100 mM)
    1 Publications Verification

    Pseudo-UTP trisodium solution (100 mM)

    		 DNA/RNA Synthesis Infection
    Pseudouridine 5'-triphosphate (Pseudo-UTP) trisodium solution (100 mM) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate trisodium solution (100 mM) enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate trisodium solution (100 mM) can be used for the research of vaccinia virus infection .
    Pseudouridine 5'-triphosphate trisodium solution (100 mM)
  • HY-10240
    Mericitabine
    5+ Cited Publications

    RG 7128; R-7128; PSI 6130 diisobutyrate

    		 HCV Infection
    Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.
    Mericitabine
  • HY-119435
    Triallate

    		Herbicide Environmental Pollutants Others
    Triallate is a selective thiocarbamate herbicide. Triallate regulates the biosynthesis of very-long-chain fatty acids and inhibits the elongation and division of plant cells. Triallate is used to control wild oats in barley, spring wheat, durum wheat, winter wheat and sugar beets .
    Triallate
  • HY-126428
    ZL0580
    1 Publications Verification

    		 HIV Epigenetic Reader Domain Infection Inflammation/Immunology
    ZL0580, a structurally close analog of ZL0590, induces epigenetic suppression of HIV via selectively binding to BD1 domain of BRD4. ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter .
    ZL0580
  • HY-P10396
    Elf18

    		Bacterial Infection Inflammation/Immunology
    Elf18 is a peptide fragment of bacterial translation elongation factor Tu (EF-Tu). Elf18 can be recognized by plant pattern recognition receptors, thereby inducing an immune response. Elf18 can enhance plants' resistance to pathogens and can be used in research related to plant immune responses .
    Elf18
  • HY-18569S3
    3-Indoleacetic acid-d7

    Indole-3-acetic acid-d7; 3-IAA-d7

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    3-Indoleacetic acid-d7 is the deuterium labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .
    3-Indoleacetic acid-d7
  • HY-18569S4
    3-Indoleacetic acid-13C6

    Indole-3-acetic acid-13C6; 3-IAA-13C6

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    3-Indoleacetic acid- 13C6 is the 13C labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .
    3-Indoleacetic acid-13C6
  • HY-P5243
    Copper tripeptide-3

    AHK-Cu

    		 Others Bcl-2 Family Others
    Copper tripeptide-3 (AHK-Cu) is a bioactive peptide with promotion of hair growth effect. Copper tripeptide-3 increases dermal cell proliferation and viability while increasing the deposition of collagen to renew the extracellular matrix. Copper tripeptide-3 stimulates the elongation of human hair follicles and proliferation of dermal papilla cells .
    Copper tripeptide-3
  • HY-134665
    NITD-2

    		Flavivirus Dengue Virus DNA/RNA Synthesis Infection
    NITD-2, a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly .
    NITD-2
  • HY-138084
    SIC5-6

    		Separase Mitosis Cancer
    SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target .
    SIC5-6
  • HY-18569S2
    3-Indoleacetic acid-2,2-d2

    Indole-3-acetic acid-2,2-d2; 3-IAA-2,2-d2

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    3-Indoleacetic acid-2,2-d2 is the deuterium labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .
    3-Indoleacetic acid-2,2-d2
  • HY-122386
    Kirromycin

    Mocimycin; Delvomycin

    		 Bacterial Antibiotic Infection
    Kirromycin (Mocimycin; Delvomycin) is an elongation factor Tu (EF-Tu) inhibitor targeting protein biosynthesis. As an antibiotic, Kirromycin exerts antibacterial activity against Gram-negative bacteria by acting on EF-Tu to interfere with the peptidyl transfer reaction. Kirromycin is applicable to studies on bacterial infections .
    Kirromycin
  • HY-B1350R
    Fusidic acid (Standard)
    1 Publications Verification

    Fusidate (Standard); SQ-16603 (Standard)

    		 Antibiotic Bacterial Reference Standards Infection Cancer
    Fusidic acid (Standard) is the analytical standard of Fusidic acid. This product is intended for research and analytical applications. Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome .
    Fusidic acid (Standard)
  • HY-141567
    Pseudouridine 5'-triphosphate

    Pseudo-UTP

    		 DNA/RNA Synthesis Infection
    Pseudouridine 5'-triphosphate (Pseudo-UTP) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate can be used for the research of vaccinia virus infection .
    Pseudouridine 5'-triphosphate
  • HY-N0273R
    Brassinolide (Standard)

    Brassin lactone (Standard)

    		 Apoptosis Reference Standards Cancer
    Brassinolide (Standard) is the analytical standard of Brassinolide. This product is intended for research and analytical applications. Brassinolide is a predominant plant growth modulator that regulate plant cell elongation.
    Brassinolide (Standard)
  • HY-N6772
    Cytochalasin E

    		Autophagy Cancer
    Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation .
    Cytochalasin E
  • HY-137868
    Decanoyl coenzyme A

    Decanoyl-coa

    		 Endogenous Metabolite Endocrinology
    Decanoyl coenzyme A (Decanoyl CoA) is a primer for the fatty acid elongation system in Mycobacterium smegmat .
    Decanoyl coenzyme A
  • HY-N9128
    Medicarpin 3-O-glucoside
    1 Publications Verification

    		 Others Others
    Medicarpin 3-O-glucoside a phytoalexin, shows inhibition against the germination of G. intraradices spores and hyphal elongation .
    Medicarpin 3-O-glucoside
  • HY-A0155
    Viomycin

    		Antibiotic Bacterial Infection
    Viomycin is a potent antibiotic against Mycobacteria. Viomycin rapidly inhibits polypeptide chain elongation when added to purified endogenous Escherichia coli polysomes actively engaged in polypeptide synthesis .
    Viomycin
  • HY-B0862R
    Pendimethalin (Standard)

    		Herbicide Reference Standards Others
    Pendimethalin (Standard) is the analytical standard of Pendimethalin. This product is intended for research and analytical applications. Pendimethalin is an herbicide that controls annual grasses and certain broadleaf weeds. Pendimethalin inhibits cell division and cell elongation .
    Pendimethalin (Standard)
  • HY-122464S1
    Jasmonic acid-d5

    		Isotope-Labeled Compounds Others
    Jasmonic acid-d5 is deuterium labeled (±)-Jasmonic acid. (±)-Jasmonic acid is a plant growth regulator and a derivative of α-linolenic acid. (±)-Jasmonic acid decreases chlorophyll levels in green and etiolated barley leaf segments and inhibits elongation of rice seedlings.
    Jasmonic acid-d5
  • HY-N9693
    Gibberellin A8

    		Drug Derivative Metabolic Disease
    Gibberellin A8 is a derivative of Gibberellic acid (HY-N1964), a hormone that is found in plants which promotes the growth and elongation of cells. Gibberellin A8 shows a weak growth-promoting activity on rice seedlings and oat mesocot .
    Gibberellin A8
  • HY-175164
    SVC112

    		Apoptosis c-Myc Cancer
    SVC112 is a translation elongation inhibitor that prevents the cyclic dissociation of EF2 from the ribosome, thereby inhibiting the elongation step of translation. SVC112 shows activity in growth inhibition among cancer cell lines of various origins (acute myeloid leukemia (AML), multiple myeloma (Myeloma), colorectal cancer (CRC), and head and neck squamous cell carcinoma (HNSCC)). SVC112 preferentially impedes ribosomal processing of mRNAs, and decreaseds CSC-related proteins including Myc and Sox2. SVC112 induces apoptosis in hematologic cancer cell lines, while phosphorylation of c-Myc correlates with sensitivity to SVC112 in colorectal cancer cell lines. SVC112 inactivates HNSCC stem cells in vitro and prevents the regrowth of HNSCC tumor xenografts in mice. SVC112 can be used for the study of HNSCC .
    SVC112
  • HY-B0771
    Cefozopran

    SCE-2787

    		 Antibiotic Bacterial Penicillin-binding protein (PBP) Infection
    Cefozopran (SCE-2787) is a potent antibiotic with broad-spectrum antibacterial activity. Cefozopran binds PBPs, induces cell wall destruction, cell elongation, filamentation, irregular septa formation, and bactericidal, bacteriolytic activity. Cefozopran reduces bacterial counts and eradicates bacteria in mouse respiratory, urinary, and thigh muscle infections. Cefozopran can be used for the research of bacterial infections .
    Cefozopran
  • HY-121231R
    trans-Caffeic acid (Standard)

    		Others Reference Standards Others
    trans-Caffeic acid (Standard) is the analytical standard of trans-Caffeic acid. This product is intended for research and analytical applications. trans-Caffeic acid is a growth stimulator that enhances the elongation growth of coleoptile sections .
    trans-Caffeic acid (Standard)
  • HY-B0862S
    Pendimethalin-d5

    		Isotope-Labeled Compounds Others
    Pendimethalin-d5 is the deuterium labeled Pendimethalin . Pendimethalin is an herbicide that controls annual grasses and certain broadleaf weeds. Pendimethalin inhibits cell division and cell elongation .
    Pendimethalin-d5
  • HY-14944R
    Homoharringtonine (Standard)

    Omacetaxine mepesuccinate (Standard); HHT (Standard)

    		 Reference Standards STAT Cancer
    Homoharringtonine (Standard) is the analytical standard of Homoharringtonine. This product is intended for research and analytical applications. Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.
    Homoharringtonine (Standard)
  • HY-N3938
    Gelsemiol

    		Others Neurological Disease
    Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells .
    Gelsemiol

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