751-94-0
751-94-0
Chemical Structure
Fusidic acid sodium salt
Synonym(s): Sodium fusidate; SQ-16360
- CAS No.: 751-94-0
- Formula:C31H47NaO6
- Molecular Weight:538.69
IUPAC Name: sodium (Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetoxy-3,11-dihydroxy-4,8,10,14-tetramethylhexadecahydro-17H-cyclopenta[a]phenanthren-17-ylidene)-6-methylhept-5-enoate
InChIKey: HJHVQCXHVMGZNC-JCJNLNMISA-M
SMILES: C[C@@H]([C@]1([H])CC[C@]([C@@](C[C@@H]/2OC(C)=O)3C)4C)[C@H](O)CC[C@]1(C)[C@]4([H])[C@H](O)C[C@@]3([H])C2=C(C(O[Na])=O)/CC/C=C(C)\C
Biological Activity: Fusidic acid sodium salt is an orally available antibacterial agent that inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid sodium salt inhibits the inhibitory and activating effects of interleukins IL-1 and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat model. Fusidic acid sodium salt improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Fusidic acid sodium salt | 99.64% | Fusidic acid sodium salt is an orally available antibacterial agent that inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid sodium salt inhibits the inhibitory and activating effects of interleukins IL-1 and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat model. Fusidic acid sodium salt improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Fusidic acid sodium salt (Standard) | ≥98% | Fusidic acid (sodium salt) (Standard) is the analytical standard of Fusidic acid (sodium salt). This product is intended for research and analytical applications. Fusidic acid sodium salt (Sodium fusidate), a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid sodium salt has no corticosteroid effects. Fusidic acid sodium salt inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Antimycobacterial agent-2 | Antimycobacterial agent-2 (compound 58) is a potent antimycobacterial agent. Antimycobacterial agent-2 shows anti-mycobacterial activities with an MIC99 of 0.8 µM for Mycobacterium tuberculosis (M.tb) H37Rv. Antimycobacterial agent-2 shows cytotoxic activities with an IC50 of48.1 µM for CHO cells. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
FA-2 | 95.0% | FA-2, a hydrogenated derivative of WU-FA-00, is an antibacterial agent that exhibits high levels of antibacterial activity against Gram-positive strains and also has some anti-inflammatory activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Zibrofusidic acid | Zibrofusidic acid (24-Bromofusidic acid; TD-1414) is a brominated derivative of Fusidic acid (HY-B1350). Zibrofusidic acid can be combined within the hydrophobic groove formed by the transmembrane helix 1 (TM1) and the transmembrane helix 2 (TM2) of the AcrB protein. Zibrofusidic acid can be used for the research of multidrug efflux pump. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Fusidic acid (Standard) | 98.26% | Fusidic acid (Standard) is the analytical standard of Fusidic acid. This product is intended for research and analytical applications. Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
11-Keto fusidic acid | 11-Keto fusidic acid shows strong antibacterial activity toward Staphylococcus aureus with an MIC value of 0.078 μg/mL. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Fusidic acid impurity 4 | Fusidic acid impurity 4 is an impurity of Fusidic acid. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
3-Keto fusidic acid | 3-Keto fusidic acid (3-keto FA) is a metabolite of Fusidic acid (HY-B1350) that is active when taken orally. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Fusidic acid impurity 5 | Fusidic acid impurity 5 (24,25-Dihydroxy Fusidic acid) is an impurity of Fusidic acid. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Fusidic acid impurity 1 | Fusidic acid impurity 1 (16-Epidesacetylfusidic acid) is an impurity of Fusidic acid. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Fusidic acid impurity 7 | Fusidic acid impurity 7 is an impurity of Fusidic acid. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. J Turnidge, et al. Fusidic acid pharmacology, pharmacokinetics and pharmacodynamics. Int J Antimicrob Agents. 1999 Aug:12 Suppl 2:S23-34. [Content Brief]
- [2]. P Collignon, et al. Fusidic acid in vitro activity. Int J Antimicrob Agents. 1999 Aug:12 Suppl 2:S45-58. [Content Brief]
- [3]. K Bendtzen, et al. Effect of fusidic acid on interleukin-1 (IL-1)- and IL-6-induced pancreatic beta-cell functions in rats. J Endocrinol. 1992 Mar;132(3):345-52. [Content Brief]
- [4]. Amanda J Payne, et al. Fusidic acid is an effective treatment against Toxoplasma gondii and Listeria monocytogenes in vitro, but not in mice. Parasitol Res. 2013 Nov;112(11):3859-63. [Content Brief]
- [5]. K Buschard, et al. Anti-diabetogenic effect of fusidic acid in diabetes prone BB rats. Autoimmunity. 1992;14(2):101-4. [Content Brief]
- [6]. Roberto Di Marco, et al. Curative effects of sodium fusidate on the development of dinitrobenzenesulfonic acid-induced colitis in rats. Clin Immunol. 2003 Dec;109(3):266-71. [Content Brief]
