1. Metabolic Enzyme/Protease
    Anti-infection
  2. HCV Protease
    HCV

R-7128 (Synonyms: RG 7128; Mericitabine; PSI 6130 diisobutyrate)

Cat. No.: HY-10240 Purity: 99.34%
Handling Instructions

R-7128 is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.

For research use only. We do not sell to patients.

R-7128 Chemical Structure

R-7128 Chemical Structure

CAS No. : 940908-79-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 297 In-stock
Estimated Time of Arrival: December 31
5 mg USD 270 In-stock
Estimated Time of Arrival: December 31
10 mg USD 367 In-stock
Estimated Time of Arrival: December 31
50 mg USD 959 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

R-7128 is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.

IC50 & Target

HCV NS5B polymerase[1]

In Vitro

R-7128 (Mericitabine) is an oral prodrug of PSI-6130, a cytidine analogue. Pre-clinical observations demonstrated that PSI-6130 has an EC90 value of 4.6±2 μM in the HCV replicon assay. R-7128 shows high specificity for HCV, minimal cytotoxicity and does not affect mitochondrial DNA. PSI-6130 is converted through phosphorylation by cellular kinases to an active 5′-triphosphate metabolite, which inhibits the NS5B RNA polymerase of HCV. R-7128 demonstrates a relatively good safety profile and significant potency against HCV-1[2]. R-7128 (Mericitabine, RG7128) is a first-in class nucleoside polymerase inhibitor (NPI), which requires intracellular uptake and phosphorylation to two active triphosphates. R-7128 is an oral cytidine nucleoside analog prodrug that exhibits strong antiviral effectiveness against the HCV polymerase across all HCV genotypes[3].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5037 mL 12.5185 mL 25.0369 mL
5 mM 0.5007 mL 2.5037 mL 5.0074 mL
10 mM 0.2504 mL 1.2518 mL 2.5037 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

399.41

Formula

C₁₈H₂₆FN₃O₆

CAS No.

940908-79-2

SMILES

O=C1N=C(C=CN1[[email protected]@H]([[email protected]@](C)([[email protected]@H]2OC(C(C)C)=O)F)O[[email protected]@H]2COC(C(C)C)=O)N

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
R-7128
Cat. No.:
HY-10240
Quantity:

R-7128

Cat. No.: HY-10240